HIT-result

Type	Detail
Target ID	T69OL5
Protein Name	Neutrophil collagenase
Uniprot ID	P22894
Protein Name Alias	EC 3.4.24.34; Matrix metalloproteinase-8; MMP-8; PMNL collagenase; PMNL-CL
Gene ID	4317
Gene Symbol	MMP8
Gene Alias	CLG1
TTD	T08856: Clinical Trial target
Pfam	PF00413 ; PF00045 ; PF01471
GO	1903978:regulation of microglial cell activation 0043410:positive regulation of MAPK cascade 0032693:negative regulation of interleukin-10 production 0010629:negative regulation of gene expression 0005615:extracellular space 1901224:positive regulation of NIK/NF-kappaB signaling 0032755:positive regulation of interleukin-6 production 0032760:positive regulation of tumor necrosis factor production 0004222:metalloendopeptidase activity 0035987:endodermal cell differentiation 1903980:positive regulation of microglial cell activation 0150078:positive regulation of neuroinflammatory response 0030574:collagen catabolic process 0005576:extracellular region 0006508:proteolysis 0022617:extracellular matrix disassembly 0046330:positive regulation of JNK cascade 0150077:regulation of neuroinflammatory response 1904724:tertiary granule lumen 0008270:zinc ion binding 0043312:neutrophil degranulation 0035580:specific granule lumen 0004175:endopeptidase activity 0004252:serine-type endopeptidase activity 0008233:peptidase activity 0045429:positive regulation of nitric oxide biosynthetic process 0030198:extracellular matrix organization 0010628:positive regulation of gene expression 1903428:positive regulation of reactive oxygen species biosynthetic process 0062023:collagen-containing extracellular matrix 0043388:positive regulation of DNA binding
PDB	1BZS ; 1ZP5 ; 3TT4 ; 4QKZ ; 1JAN ; 1JAP ; 1JAQ ; 1A85 ; 1MMB ; 1ZS0 ; 5H8X ; 1A86 ; 1ZVX ; 1KBC ; 3DPF ; 1MNC ; 1JAO ; 1I73 ; 1I76 ; 1JJ9 ; 3DPE ; 2OY2 ; 3DNG ; 1JH1 ; 2OY4
Drugbank	DB08476 ; DB00786 ; DB07397 ; DB06971 ; DB03207 ; DB07772 ; DB03622 ; DB03636 ; DB02326 ; DB07713 ; DB08403 ; DB08028 ; DB03880 ; DB02953 ; DB07900
KEGG	hsa:4317

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Name: Glycitein

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Name: Acetaminophen

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H1175	Hei Dou	黑豆	Black bean	Semen glycine max
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens