HIT-result

Target Description

Type	Detail
Target ID	T69VTW
Protein Name	Syntaxin-binding protein 1
Uniprot ID	P61764
Protein Name Alias	MUNC18-1; N-Sec1; Protein unc-18 homolog 1; Unc18-1; Protein unc-18 homolog A; Unc-18A; p67
Gene ID	6812
Gene Symbol	STXBP1
Gene Alias	UNC18A
TTD	NA
Pfam	PF00995
GO	0042802:identical protein binding 0006836:neurotransmitter transport 0070062:extracellular exosome 0043306:positive regulation of mast cell degranulation 0031091:platelet alpha granule 0045335:phagocytic vesicle 0043274:phospholipase binding 0043524:negative regulation of neuron apoptotic process 0030424:axon 0005829:cytosol 0019904:protein domain specific binding 0032229:negative regulation of synaptic transmission, GABAergic 0098794:postsynapse 0098978:glutamatergic synapse 0060292:long-term synaptic depression 0007274:neuromuscular synaptic transmission 0106022:positive regulation of vesicle docking 0005737:cytoplasm 0006904:vesicle docking involved in exocytosis 0035493:SNARE complex assembly 0019905:syntaxin binding 0019901:protein kinase binding 0007412:axon target recognition 0071346:cellular response to interferon-gamma 0005886:plasma membrane 0048471:perinuclear region of cytoplasm 0030141:secretory granule 0032355:response to estradiol 0010807:regulation of synaptic vesicle priming 0007269:neurotransmitter secretion 0016082:synaptic vesicle priming 0005856:cytoskeleton 0099525:presynaptic dense core vesicle exocytosis 0050821:protein stabilization 0048787:presynaptic active zone membrane 0017075:syntaxin-1 binding 0003723:RNA binding 0070527:platelet aggregation 0016192:vesicle-mediated transport 0072659:protein localization to plasma membrane 0032991:protein-containing complex 0031333:negative regulation of protein-containing complex assembly 0000149:SNARE binding 0035542:regulation of SNARE complex assembly 0045956:positive regulation of calcium ion-dependent exocytosis 0003006:developmental process involved in reproduction 0005739:mitochondrion 0031630:regulation of synaptic vesicle fusion to presynaptic active zone membrane 1903296:positive regulation of glutamate secretion, neurotransmission 0005654:nucleoplasm 0016188:synaptic vesicle maturation 0006886:intracellular protein transport 2000367:regulation of acrosomal vesicle exocytosis 0047485:protein N-terminus binding 0002576:platelet degranulation
PDB	6L03
Drugbank	NA
KEGG	hsa:6812

Type

Detail

Target ID

T69VTW

Protein Name

Syntaxin-binding protein 1

Uniprot ID

P61764

Protein Name Alias

MUNC18-1; N-Sec1; Protein unc-18 homolog 1; Unc18-1; Protein unc-18 homolog A; Unc-18A; p67

Gene ID

6812

Gene Symbol

STXBP1

Gene Alias

UNC18A

TTD

Pfam

PF00995

0042802:identical protein binding

0006836:neurotransmitter transport

0070062:extracellular exosome

0043306:positive regulation of mast cell degranulation

0031091:platelet alpha granule

0045335:phagocytic vesicle

0043274:phospholipase binding

0043524:negative regulation of neuron apoptotic process

0030424:axon

0005829:cytosol

0019904:protein domain specific binding

0032229:negative regulation of synaptic transmission, GABAergic

0098794:postsynapse

0098978:glutamatergic synapse

0060292:long-term synaptic depression

0007274:neuromuscular synaptic transmission

0106022:positive regulation of vesicle docking

0005737:cytoplasm

0006904:vesicle docking involved in exocytosis

0035493:SNARE complex assembly

0019905:syntaxin binding

0019901:protein kinase binding

0007412:axon target recognition

0071346:cellular response to interferon-gamma

0005886:plasma membrane

0048471:perinuclear region of cytoplasm

0030141:secretory granule

0032355:response to estradiol

0010807:regulation of synaptic vesicle priming

0007269:neurotransmitter secretion

0016082:synaptic vesicle priming

0005856:cytoskeleton

0099525:presynaptic dense core vesicle exocytosis

0050821:protein stabilization

0048787:presynaptic active zone membrane

0017075:syntaxin-1 binding

0003723:RNA binding

0070527:platelet aggregation

0016192:vesicle-mediated transport

0072659:protein localization to plasma membrane

0032991:protein-containing complex

0031333:negative regulation of protein-containing complex assembly

0000149:SNARE binding

0035542:regulation of SNARE complex assembly

0045956:positive regulation of calcium ion-dependent exocytosis

0003006:developmental process involved in reproduction

0005739:mitochondrion

0031630:regulation of synaptic vesicle fusion to presynaptic active zone membrane

1903296:positive regulation of glutamate secretion, neurotransmission

0005654:nucleoplasm

0016188:synaptic vesicle maturation

0006886:intracellular protein transport

2000367:regulation of acrosomal vesicle exocytosis

0047485:protein N-terminus binding

0002576:platelet degranulation

PDB

6L03

Drugbank

KEGG

hsa:6812

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0919	Cui Yun Cao	翠云草	Hooked spikemoss	Selaginella uncinata
H1090	Gao Ben	藁本	Chinese ligusticum	Ligusticum sinense
H0463	Shi Liu Pi	石榴皮	Pomegranate peel	Punica granatum
H0462	Shi Liu	石榴	Pomegranate fruit	Punica granatum
H0515	Suan Shi Liu	酸石榴	Pomegranate	Punica granatum
H0464	Shi Liu Zi	石榴子	NA	Punica granatum
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0060	Jin Si Ku Lian	金丝苦楝	NA	Cardiospermum halicacabum
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens

Target Description

Related Compounds (Total: 1)

Related Herbs (Total: 9)