HIT-result

Target Description

Type	Detail
Target ID	T71DUF
Protein Name	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
Uniprot ID	Q08209
Protein Name Alias	EC 3.1.3.16; CAM-PRP catalytic subunit; Calmodulin-dependent calcineurin A subunit alpha isoform
Gene ID	5530
Gene Symbol	PPP3CA
Gene Alias	CALNA; CNA
TTD	T25464: Successful target
Pfam	PF00149
GO	0060079:excitatory postsynaptic potential 0051091:positive regulation of DNA-binding transcription factor activity 0033555:multicellular organismal response to stress 0006470:protein dephosphorylation 0007223:Wnt signaling pathway, calcium modulating pathway 0030018:Z disc 0050774:negative regulation of dendrite morphogenesis 1903244:positive regulation of cardiac muscle hypertrophy in response to stress 0046983:protein dimerization activity 1903799:negative regulation of production of miRNAs involved in gene silencing by miRNA 0043197:dendritic spine 0097720:calcineurin-mediated signaling 0006606:protein import into nucleus 0045785:positive regulation of cell adhesion 0007420:brain development 0038095:Fc-epsilon receptor signaling pathway 0005829:cytosol 0051592:response to calcium ion 0005516:calmodulin binding 0044877:protein-containing complex binding 0006816:calcium ion transport 0071333:cellular response to glucose stimulus 1905205:positive regulation of connective tissue replacement 0043403:skeletal muscle tissue regeneration 0098685:Schaffer collateral - CA1 synapse 0004722:protein serine/threonine phosphatase activity 0046676:negative regulation of insulin secretion 0005886:plasma membrane 0016311:dephosphorylation 0033173:calcineurin-NFAT signaling cascade 0042110:T cell activation 0005654:nucleoplasm 0098978:glutamatergic synapse 0106306:protein serine phosphatase activity 0042383:sarcolemma 0036057:slit diaphragm 0051117:ATPase binding 0033192:calmodulin-dependent protein phosphatase activity 0005737:cytoplasm 0019899:enzyme binding 0045807:positive regulation of endocytosis 0014883:transition between fast and slow fiber 0035562:negative regulation of chromatin binding 0030335:positive regulation of cell migration 0016018:cyclosporin A binding 0005739:mitochondrion 0045944:positive regulation of transcription by RNA polymerase II 0001975:response to amphetamine 0070262:peptidyl-serine dephosphorylation 0014898:cardiac muscle hypertrophy in response to stress 0005955:calcineurin complex 0005509:calcium ion binding 0042060:wound healing 0099170:postsynaptic modulation of chemical synaptic transmission 0106307:protein threonine phosphatase activity 0000082:G1/S transition of mitotic cell cycle 0048741:skeletal muscle fiber development 0007568:aging 0019897:extrinsic component of plasma membrane
PDB	4Q5U ; 2P6B ; 6NUU ; 2JOG ; 3LL8 ; 5C1V ; 2JZI ; 1M63 ; 5SVE ; 6UUQ ; 6NUF ; 1AUI ; 1MF8 ; 4F0Z ; 2W73 ; 2R28 ; 6NUC
Drugbank	DB08231
KEGG	hsa:5530

Type

Detail

Target ID

T71DUF

Protein Name

Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform

Uniprot ID

Q08209

Protein Name Alias

EC 3.1.3.16; CAM-PRP catalytic subunit; Calmodulin-dependent calcineurin A subunit alpha isoform

Gene ID

5530

Gene Symbol

PPP3CA

Gene Alias

CALNA; CNA

TTD

T25464: Successful target

Pfam

PF00149

0060079:excitatory postsynaptic potential

0051091:positive regulation of DNA-binding transcription factor activity

0033555:multicellular organismal response to stress

0006470:protein dephosphorylation

0007223:Wnt signaling pathway, calcium modulating pathway

0030018:Z disc

0050774:negative regulation of dendrite morphogenesis

1903244:positive regulation of cardiac muscle hypertrophy in response to stress

0046983:protein dimerization activity

1903799:negative regulation of production of miRNAs involved in gene silencing by miRNA

0043197:dendritic spine

0097720:calcineurin-mediated signaling

0006606:protein import into nucleus

0045785:positive regulation of cell adhesion

0007420:brain development

0038095:Fc-epsilon receptor signaling pathway

0005829:cytosol

0051592:response to calcium ion

0005516:calmodulin binding

0044877:protein-containing complex binding

0006816:calcium ion transport

0071333:cellular response to glucose stimulus

1905205:positive regulation of connective tissue replacement

0043403:skeletal muscle tissue regeneration

0098685:Schaffer collateral - CA1 synapse

0004722:protein serine/threonine phosphatase activity

0046676:negative regulation of insulin secretion

0005886:plasma membrane

0016311:dephosphorylation

0033173:calcineurin-NFAT signaling cascade

0042110:T cell activation

0005654:nucleoplasm

0098978:glutamatergic synapse

0106306:protein serine phosphatase activity

0042383:sarcolemma

0036057:slit diaphragm

0051117:ATPase binding

0033192:calmodulin-dependent protein phosphatase activity

0005737:cytoplasm

0019899:enzyme binding

0045807:positive regulation of endocytosis

0014883:transition between fast and slow fiber

0035562:negative regulation of chromatin binding

0030335:positive regulation of cell migration

0016018:cyclosporin A binding

0005739:mitochondrion

0045944:positive regulation of transcription by RNA polymerase II

0001975:response to amphetamine

0070262:peptidyl-serine dephosphorylation

0014898:cardiac muscle hypertrophy in response to stress

0005955:calcineurin complex

0005509:calcium ion binding

0042060:wound healing

0099170:postsynaptic modulation of chemical synaptic transmission

0106307:protein threonine phosphatase activity

0000082:G1/S transition of mitotic cell cycle

0048741:skeletal muscle fiber development

0007568:aging

0019897:extrinsic component of plasma membrane

PDB

4Q5U ; 2P6B ; 6NUU ; 2JOG ; 3LL8 ; 5C1V ; 2JZI ; 1M63 ; 5SVE ; 6UUQ ; 6NUF ; 1AUI ; 1MF8 ; 4F0Z ; 2W73 ; 2R28 ; 6NUC

Drugbank

DB08231

KEGG

hsa:5530

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H1067	Gan Cao Fen	甘草粉	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0137	Ban Lan Gen	板蓝根	Indigowoad root	Isatis indigotica
H0265	Mu Da Qing Ye	木大青叶	Indigo-coloured woad leaf equivalent	Isatis indigotica
H0444	Sheng Gan Cao	生甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1075	Gan Cao Liu Jin Gao	甘草流浸膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0263	Mu Ban Lan Gen	木板蓝根	Indigowoad root	Isatis indigotica
H0937	Da Qing Ye	大青叶	Indigo-coloured woad leaf	Isatis indigotica
H0240	Mi Gan Cao	蜜甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0131	Ban Lan	板蓝	Indigowoad root	Isatis indigotica
H1066	Gan Cao	甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1072	Gan Cao Gao	甘草膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0571	Tu Gan Cao	土甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1074	Gan Cao Jin Gao	甘草浸膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1071	Gan Cao Gan Jin Gao	甘草干浸膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1073	Gan Cao Jie	甘草节	Glycyrrhiza uralensis fisch	Glycyrrhiza uralensis
H1070	Gan Cao Gan Gao Fen	甘草干膏粉	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1069	Gan Cao Gan Gao	甘草干膏	Glycyrrhiza inflata	Glycyrrhiza uralensis

Target Description

Related Compounds (Total: 1)

Related Herbs (Total: 17)