HIT-result

Type	Detail
Target ID	T75GKT
Protein Name	Mothers against decapentaplegic homolog 4
Uniprot ID	Q13485
Protein Name Alias	MAD homolog 4; Mothers against DPP homolog 4; Deletion target in pancreatic carcinoma 4; SMAD family member 4; SMAD 4; Smad4; hSMAD4
Gene ID	4089
Gene Symbol	SMAD4
Gene Alias	DPC4; MADH4
TTD	NA
Pfam	PF03165 ; PF03166
GO	0140537:transcription regulator activator activity 0030509:BMP signaling pathway 0010862:positive regulation of pathway-restricted SMAD protein phosphorylation 0060391:positive regulation of SMAD protein signal transduction 0035556:intracellular signal transduction 0007179:transforming growth factor beta receptor signaling pathway 0003220:left ventricular cardiac muscle tissue morphogenesis 0001658:branching involved in ureteric bud morphogenesis 0007183:SMAD protein complex assembly 0003251:positive regulation of cell proliferation involved in heart valve morphogenesis 0003148:outflow tract septum morphogenesis 0060548:negative regulation of cell death 0008285:negative regulation of cell population proliferation 0051571:positive regulation of histone H3-K4 methylation 0007338:single fertilization 0070411:I-SMAD binding 0010614:negative regulation of cardiac muscle hypertrophy 0030308:negative regulation of cell growth 0030514:negative regulation of BMP signaling pathway 0005667:transcription regulator complex 0051797:regulation of hair follicle development 0048859:formation of anatomical boundary 0045944:positive regulation of transcription by RNA polymerase II 0070373:negative regulation of ERK1 and ERK2 cascade 1902895:positive regulation of pri-miRNA transcription by RNA polymerase II 0042802:identical protein binding 0005813:centrosome 0030513:positive regulation of BMP signaling pathway 0036302:atrioventricular canal development 0062009:secondary palate development 0005829:cytosol 0042118:endothelial cell activation 0003682:chromatin binding 0071559:response to transforming growth factor beta 0005737:cytoplasm 0030154:cell differentiation 0005518:collagen binding 0001228:DNA-binding transcription activator activity, RNA polymerase II-specific 0032525:somite rostral/caudal axis specification 0071773:cellular response to BMP stimulus 0048382:mesendoderm development 0043199:sulfate binding 0060395:SMAD protein signal transduction 0006879:cellular iron ion homeostasis 0048663:neuron fate commitment 0071141:SMAD protein complex 0046872:metal ion binding 0008283:cell population proliferation 2000617:positive regulation of histone H3-K9 acetylation 0001702:gastrulation with mouth forming second 0005634:nucleus 0072520:seminiferous tubule development 0060956:endocardial cell differentiation 0051098:regulation of binding 0071144:heteromeric SMAD protein complex 0061040:female gonad morphogenesis 0033686:positive regulation of luteinizing hormone secretion 0032444:activin responsive factor complex 0003360:brainstem development 0048733:sebaceous gland development 0072134:nephrogenic mesenchyme morphogenesis 0001666:response to hypoxia 0001085:RNA polymerase II transcription factor binding 0001223:transcription coactivator binding 0003198:epithelial to mesenchymal transition involved in endocardial cushion formation 0032909:regulation of transforming growth factor beta2 production 0001701:in utero embryonic development 0060065:uterus development 0070412:R-SMAD binding 0010718:positive regulation of epithelial to mesenchymal transition 0045893:positive regulation of transcription, DNA-templated 0000122:negative regulation of transcription by RNA polymerase II 0042803:protein homodimerization activity 0000978:RNA polymerase II cis-regulatory region sequence-specific DNA binding 0072133:metanephric mesenchyme morphogenesis 0016579:protein deubiquitination 0007283:spermatogenesis 0048589:developmental growth 0060412:ventricular septum morphogenesis 0070102:interleukin-6-mediated signaling pathway 0046881:positive regulation of follicle-stimulating hormone secretion 0030511:positive regulation of transforming growth factor beta receptor signaling pathway 0035019:somatic stem cell population maintenance 0017015:regulation of transforming growth factor beta receptor signaling pathway 0042733:embryonic digit morphogenesis 0009653:anatomical structure morphogenesis 0045892:negative regulation of transcription, DNA-templated 0014033:neural crest cell differentiation 1905305:negative regulation of cardiac myofibril assembly 0003190:atrioventricular valve formation 0000785:chromatin 0000976:transcription regulatory region sequence-specific DNA binding 1901522:positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus 0000981:DNA-binding transcription factor activity, RNA polymerase II-specific 0001541:ovarian follicle development 0005654:nucleoplasm 0007411:axon guidance
PDB	1G88 ; 1MR1 ; 5MEY ; 5UWU ; 1DD1 ; 1YGS ; 1U7V ; 5MF0 ; 1U7F ; 5C4V ; 5MEZ
Drugbank	NA
KEGG	hsa:4089

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Name: Valproic Acid

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens