Target Description

Type Detail
Target ID T75MO6
Protein Name Tyrosine-protein kinase ABL1
Uniprot ID P00519
Protein Name Alias EC;  Abelson murine leukemia viral oncogene homolog 1;  Abelson tyrosine-protein kinase 1;  Proto-oncogene c-Abl;  p150
Gene ID 25
Gene Symbol ABL1
Gene Alias ABL;  JTK7
TTD T63505: Successful target
Pfam PF00017 ; PF07714 ; PF00018 ; PF08919
0072359:circulatory system development

2000096:positive regulation of Wnt signaling pathway, planar cell polarity pathway

0008630:intrinsic apoptotic signaling pathway in response to DNA damage

0004672:protein kinase activity

0007050:cell cycle arrest

0042169:SH2 domain binding

2000773:negative regulation of cellular senescence

0050853:B cell receptor signaling pathway

0007204:positive regulation of cytosolic calcium ion concentration

1903351:cellular response to dopamine

0034599:cellular response to oxidative stress

0051281:positive regulation of release of sequestered calcium ion into cytosol

0048538:thymus development

0032956:regulation of actin cytoskeleton organization

0070064:proline-rich region binding

1900275:negative regulation of phospholipase C activity

0001843:neural tube closure

0032729:positive regulation of interferon-gamma production

0017124:SH3 domain binding


0030514:negative regulation of BMP signaling pathway

0022408:negative regulation of cell-cell adhesion

0070374:positive regulation of ERK1 and ERK2 cascade

0050885:neuromuscular process controlling balance

2000249:regulation of actin cytoskeleton reorganization

0004715:non-membrane spanning protein tyrosine kinase activity

0007229:integrin-mediated signaling pathway

0006979:response to oxidative stress

0045184:establishment of protein localization

0030516:regulation of axon extension


0038191:neuropilin binding

0051015:actin filament binding

0051894:positive regulation of focal adhesion assembly

0045944:positive regulation of transcription by RNA polymerase II

0070373:negative regulation of ERK1 and ERK2 cascade

0003677:DNA binding

0051019:mitogen-activated protein kinase binding

0046777:protein autophosphorylation

0000405:bubble DNA binding

0042981:regulation of apoptotic process

0042770:signal transduction in response to DNA damage

0050798:activated T cell proliferation


0046875:ephrin receptor binding

0051496:positive regulation of stress fiber assembly

2000352:negative regulation of endothelial cell apoptotic process

0043542:endothelial cell migration

2001020:regulation of response to DNA damage stimulus

0071222:cellular response to lipopolysaccharide

0002322:B cell proliferation involved in immune response

0033690:positive regulation of osteoblast proliferation

0002333:transitional one stage B cell differentiation


1905244:regulation of modification of synaptic structure

0019905:syntaxin binding

1904528:positive regulation of microtubule binding

0005524:ATP binding

0001934:positive regulation of protein phosphorylation

0048471:perinuclear region of cytoplasm

0050731:positive regulation of peptidyl-tyrosine phosphorylation

0060563:neuroepithelial cell differentiation

0003785:actin monomer binding

1900272:negative regulation of long-term synaptic potentiation

1901216:positive regulation of neuron death

0045931:positive regulation of mitotic cell cycle

0006468:protein phosphorylation

0046632:alpha-beta T cell differentiation

0030100:regulation of endocytosis

0001922:B-1 B cell homeostasis


0031113:regulation of microtubule polymerization

0090135:actin filament branching

0010506:regulation of autophagy


2000251:positive regulation of actin cytoskeleton reorganization

1905555:positive regulation of blood vessel branching

0018108:peptidyl-tyrosine phosphorylation

0043124:negative regulation of I-kappaB kinase/NF-kappaB signaling

0006355:regulation of transcription, DNA-templated

0009791:post-embryonic development

0003713:transcription coactivator activity

0051444:negative regulation of ubiquitin-protein transferase activity

0034446:substrate adhesion-dependent cell spreading

0030035:microspike assembly

0016301:kinase activity

1990051:activation of protein kinase C activity

0032489:regulation of Cdc42 protein signal transduction

0071901:negative regulation of protein serine/threonine kinase activity

0035791:platelet-derived growth factor receptor-beta signaling pathway

0048536:spleen development


0031252:cell leading edge

0031965:nuclear membrane

0004515:nicotinate-nucleotide adenylyltransferase activity

0030145:manganese ion binding

0045580:regulation of T cell differentiation

0051882:mitochondrial depolarization

0043123:positive regulation of I-kappaB kinase/NF-kappaB signaling

0038096:Fc-gamma receptor signaling pathway involved in phagocytosis

0004714:transmembrane receptor protein tyrosine kinase activity

1900026:positive regulation of substrate adhesion-dependent cell spreading

0015629:actin cytoskeleton

1990837:sequence-specific double-stranded DNA binding

0048668:collateral sprouting

0006298:mismatch repair

0006975:DNA damage induced protein phosphorylation


0070301:cellular response to hydrogen peroxide


0038189:neuropilin signaling pathway

0038083:peptidyl-tyrosine autophosphorylation

0010595:positive regulation of endothelial cell migration

0004713:protein tyrosine kinase activity

0030036:actin cytoskeleton organization

1903053:regulation of extracellular matrix organization

0050852:T cell receptor signaling pathway

0051149:positive regulation of muscle cell differentiation

0000287:magnesium ion binding

0051353:positive regulation of oxidoreductase activity

0001784:phosphotyrosine residue binding

0006464:cellular protein modification process

0005080:protein kinase C binding

0030155:regulation of cell adhesion

0032743:positive regulation of interleukin-2 production

0032991:protein-containing complex

0016604:nuclear body

0007173:epidermal growth factor receptor signaling pathway

0021587:cerebellum morphogenesis

0043065:positive regulation of apoptotic process

0000400:four-way junction DNA binding

0071103:DNA conformation change

0000278:mitotic cell cycle

0008022:protein C-terminus binding

0060020:Bergmann glial cell differentiation


0043025:neuronal cell body

0045930:negative regulation of mitotic cell cycle

2000145:regulation of cell motility

1904531:positive regulation of actin filament binding

0006974:cellular response to DNA damage stimulus

0090050:positive regulation of cell migration involved in sprouting angiogenesis

1902036:regulation of hematopoietic stem cell differentiation

PDB 3EG0 ; 1AB2 ; 2F4J ; 4J9C ; 5OAZ ; 2V7A ; 4J9B ; 3QRK ; 4XEY ; 5DC0 ; 6AMV ; 2GQG ; 4J9E ; 2G2I ; 3CS9 ; 2ABL ; 2G2F ; 4J9H ; 3EG1 ; 2HZI ; 3UE4 ; 2HZ4 ; 3UYO ; 5NP2 ; 5DC9 ; 2HIW ; 4JJD ; 1ABL ; 3EG2 ; 3T04 ; 4YC8 ; 6XRG ; 1AWO ; 1JU5 ; 3QRI ; 4J9I ; 1BBZ ; 2HZ0 ; 6NPU ; 4J9F ; 5MO4 ; 4J9D ; 4WA9 ; 2G1T ; 5HU9 ; 4TWP ; 2E2B ; 4ZOG ; 2G2H ; 3QRJ ; 6XR6 ; 5DC4 ; 3EG3 ; 1ZZP ; 3PYY ; 6BL8 ; 6NPE ; 6AMW ; 3K2M ; 6XR7 ; 1OPL ; 4JJB ; 2O88 ; 3EGU ; 4JJC ; 6NPV ; 2FO0 ; 2HYY ; 4J9G
Drugbank DB08231 ; DB12010 ; DB01254 ; DB08896 ; DB08901 ; DB13749 ; DB08583 ; DB12323 ; DB04868 ; DB12267 ; DB07831 ; DB08339 ; DB05184 ; DB08350 ; DB03878 ; DB00171 ; DB06616 ; DB00619 ; DB08043
KEGG hsa:25

Related Compounds  (Total: 3)

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Name: Acetaminophen

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