HIT-result

Type	Detail
Target ID	T76WHR
Protein Name	Macrophage metalloelastase
Uniprot ID	P39900
Protein Name Alias	MME; EC 3.4.24.65; Macrophage elastase; ME; hME; Matrix metalloproteinase-12; MMP-12
Gene ID	4321
Gene Symbol	MMP12
Gene Alias	HME
TTD	T03500: Clinical Trial target
Pfam	PF01471 ; PF00413 ; PF00045
GO	0022617:extracellular matrix disassembly 0005634:nucleus 0006508:proteolysis 0043565:sequence-specific DNA binding 0060340:positive regulation of type I interferon-mediated signaling pathway 0001046:core promoter sequence-specific DNA binding 0050691:regulation of defense response to virus by host 0004222:metalloendopeptidase activity 0032727:positive regulation of interferon-alpha production 0035313:wound healing, spreading of epidermal cells 0005509:calcium ion binding 1904905:negative regulation of endothelial cell-matrix adhesion via fibronectin 0005615:extracellular space 0098586:cellular response to virus 0030198:extracellular matrix organization 0005518:collagen binding 0006606:protein import into nucleus 0030574:collagen catabolic process 1904645:response to amyloid-beta 0031012:extracellular matrix 0060339:negative regulation of type I interferon-mediated signaling pathway 0048286:lung alveolus development 0005576:extracellular region 0060435:bronchiole development 0000122:negative regulation of transcription by RNA polymerase II 0008270:zinc ion binding 0005737:cytoplasm 0060309:elastin catabolic process 0045944:positive regulation of transcription by RNA polymerase II 0060054:positive regulation of epithelial cell proliferation involved in wound healing 0004175:endopeptidase activity
PDB	4H84 ; 5L7F ; 2W0D ; 1Y93 ; 3F19 ; 2OXU ; 6RD0 ; 4H30 ; 3LIR ; 4IJO ; 2KRJ ; 2N8R ; 3F16 ; 3RTT ; 1RMZ ; 2OXZ ; 1JK3 ; 3EHY ; 1ROS ; 5D3C ; 5D2B ; 5N5J ; 2K9C ; 3RTS ; 2POJ ; 4GUY ; 5L79 ; 1UTZ ; 3N2U ; 2WOA ; 5N5K ; 5I4O ; 1UTT ; 5CXA ; 3F1A ; 3LK8 ; 3N2V ; 1YCM ; 2OXW ; 5I2Z ; 6ENM ; 3LKA ; 2K2G ; 3TS4 ; 3LJG ; 6RLY ; 6EOX ; 2Z2D ; 1Z3J ; 4GR0 ; 4H49 ; 4H76 ; 6ELA ; 4GR8 ; 5I0L ; 5I43 ; 2MLS ; 3F17 ; 2JXY ; 3F18 ; 3BA0 ; 2WO9 ; 2HU6 ; 4EFS ; 1JIZ ; 2WO8 ; 5I3M ; 3UVC ; 3LIK ; 1OS2 ; 2MLR ; 3F15 ; 3NX7 ; 3LIL ; 4I03 ; 3EHX ; 6EKN ; 3TSK ; 4GQL ; 4GR3 ; 1OS9 ; 5LAB ; 5CZM
Drugbank	DB07921 ; DB00013 ; DB03880 ; DB07556 ; DB07920 ; DB03367 ; DB00551 ; DB07683 ; DB08599 ; DB00786 ; DB08271 ; DB02118 ; DB05387 ; DB07922 ; DB07026 ; DB07446 ; DB04405
KEGG	hsa:4321

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Name: Alcohol

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0358	Ren Shen Ye	人参叶	Ginseng leaf	Panax ginseng
H0955	Dang Gui	当归	Chinese angelica	Angelica sinensis
H0522	Tai Zi Shen	太子参	Heterophylly falsestarwort root	Radix pseudostellariae
H0154	Ai Ye You	艾叶油	Argy wormwood leaf	Artemisia argyi
H0103	Ai Ye	艾叶	Argy wormwood leaf	Artemisia argyi
H0416	Shan Shen	山参	NA	Panax ginseng
H0173	Lu Hui	芦荟	Kulaso aloe dried juice	Aloe vera
H0938	Da Suan	大蒜	Garlic	Allium sativum
H0357	Ren Shen	人参	Ginseng	Panax ginseng
H0956	Dang Gui Gan Jin Gao	当归干浸膏	NA	Angelica sinensis
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens