HIT-result

Type	Detail
Target ID	T77INT
Protein Name	Lymphotoxin-alpha
Uniprot ID	P01374
Protein Name Alias	LT-alpha; TNF-beta; Tumor necrosis factor ligand superfamily member 1
Gene ID	4049
Gene Symbol	LTA
Gene Alias	TNFB; TNFSF1
TTD	T85158: Clinical Trial target
Pfam	PF00229
GO	0006915:apoptotic process 0042493:response to drug 0005615:extracellular space 0006959:humoral immune response 0002925:positive regulation of humoral immune response mediated by circulating immunoglobulin 0002876:positive regulation of chronic inflammatory response to antigenic stimulus 0001666:response to hypoxia 0005164:tumor necrosis factor receptor binding 0005886:plasma membrane 0043065:positive regulation of apoptotic process 0048535:lymph node development 0005102:signaling receptor binding 0007584:response to nutrient 0007165:signal transduction 0005125:cytokine activity 0060252:positive regulation of glial cell proliferation 0032496:response to lipopolysaccharide 0032729:positive regulation of interferon-gamma production 0050830:defense response to Gram-positive bacterium 0033209:tumor necrosis factor-mediated signaling pathway 0048147:negative regulation of fibroblast proliferation 0007267:cell-cell signaling
PDB	4MXV ; 4MXW ; 1TNR
Drugbank	DB00005
KEGG	hsa:4049

Target Description