HIT-result

Type	Detail
Target ID	T77X36
Protein Name	Sodium channel protein type 5 subunit alpha
Uniprot ID	Q14524
Protein Name Alias	Sodium channel protein cardiac muscle subunit alpha; Sodium channel protein type V subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.5; hH1
Gene ID	6331
Gene Symbol	SCN5A
Gene Alias	NA
TTD	T39716: Successful target
Pfam	PF06512 ; PF00520 ; PF11933
GO	0006814:sodium ion transport 0086014:atrial cardiac muscle cell action potential 0021537:telencephalon development 0086063:voltage-gated sodium channel activity involved in SA node cell action potential 0014704:intercalated disc 0030018:Z disc 0019904:protein domain specific binding 0086048:membrane depolarization during bundle of His cell action potential 0016021:integral component of membrane 0009986:cell surface 0031625:ubiquitin protein ligase binding 0005244:voltage-gated ion channel activity 0019228:neuronal action potential 0050679:positive regulation of epithelial cell proliferation 0086012:membrane depolarization during cardiac muscle cell action potential 0005730:nucleolus 0086062:voltage-gated sodium channel activity involved in Purkinje myocyte action potential 0086002:cardiac muscle cell action potential involved in contraction 0060048:cardiac muscle contraction 0086010:membrane depolarization during action potential 0060373:regulation of ventricular cardiac muscle cell membrane depolarization 0060371:regulation of atrial cardiac muscle cell membrane depolarization 0086004:regulation of cardiac muscle cell contraction 0005248:voltage-gated sodium channel activity 0086045:membrane depolarization during AV node cell action potential 0086091:regulation of heart rate by cardiac conduction 0086006:voltage-gated sodium channel activity involved in cardiac muscle cell action potential 0086043:bundle of His cell action potential 0017134:fibroblast growth factor binding 0005901:caveola 0005516:calmodulin binding 0014894:response to denervation involved in regulation of muscle adaptation 0097110:scaffold protein binding 0086047:membrane depolarization during Purkinje myocyte cell action potential 0005886:plasma membrane 0002027:regulation of heart rate 0030315:T-tubule 0050998:nitric-oxide synthase binding 0005654:nucleoplasm 0042475:odontogenesis of dentin-containing tooth 0042383:sarcolemma 0019899:enzyme binding 0044325:ion channel binding 0086015:SA node cell action potential 0051899:membrane depolarization 0048471:perinuclear region of cytoplasm 0005783:endoplasmic reticulum 0086061:voltage-gated sodium channel activity involved in bundle of His cell action potential 1902305:regulation of sodium ion transmembrane transport 0061337:cardiac conduction 0045760:positive regulation of action potential 0030506:ankyrin binding 0086060:voltage-gated sodium channel activity involved in AV node cell action potential 0086067:AV node cell to bundle of His cell communication 0086005:ventricular cardiac muscle cell action potential 0019901:protein kinase binding 0071277:cellular response to calcium ion 0086046:membrane depolarization during SA node cell action potential 0060307:regulation of ventricular cardiac muscle cell membrane repolarization 0035725:sodium ion transmembrane transport 0001518:voltage-gated sodium channel complex 0098912:membrane depolarization during atrial cardiac muscle cell action potential 0003360:brainstem development 0060372:regulation of atrial cardiac muscle cell membrane repolarization 0003231:cardiac ventricle development 0010765:positive regulation of sodium ion transport 0016328:lateral plasma membrane 0021549:cerebellum development 0086016:AV node cell action potential
PDB	4DJC ; 6MUD ; 4DCK ; 4OVN ; 2KBI ; 2L53 ; 4JQ0 ; 5DBR
Drugbank	DB00532 ; DB00281 ; DB13961 ; DB00740 ; DB00379 ; DB00527 ; DB09088 ; DB01035 ; DB00680 ; DB11633 ; DB01346 ; DB09085 ; DB00280 ; DB01182 ; DB11186 ; DB00908 ; DB06217 ; DB01056 ; DB00243 ; DB01069 ; DB00192 ; DB00776 ; DB00555 ; DB09342 ; DB01429 ; DB13269 ; DB09345 ; DB01195 ; DB01426 ; DB00252 ; DB01320 ; DB00473 ; DB00907 ; DB00909 ; DB01228 ; DB00564 ; DB00273 ; DB13746 ; DB00313 ; DB05541 ; DB00754 ; DB00750 ; DB04855 ; DB00868
KEGG	hsa:6331

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Name: Tetrodotoxin

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H1205	Hu Lu Cha	葫芦茶	Triquetrous tadehagi	Tadehagi triquetrum