HIT-result

Target Description

Type	Detail
Target ID	T79O0V
Protein Name	Beta-3 adrenergic receptor
Uniprot ID	P13945
Protein Name Alias	Beta-3 adrenoreceptor; Beta-3 adrenoceptor
Gene ID	155
Gene Symbol	ADRB3
Gene Alias	ADRB3R; B3AR
TTD	T51408: Successful target
Pfam	PF00001
GO	0043410:positive regulation of MAPK cascade 0051379:epinephrine binding 0120162:positive regulation of cold-induced thermogenesis 0007187:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 0002862:negative regulation of inflammatory response to antigenic stimulus 0005887:integral component of plasma membrane 0006112:energy reserve metabolic process 0007186:G protein-coupled receptor signaling pathway 0006091:generation of precursor metabolites and energy 0004939:beta-adrenergic receptor activity 0015052:beta3-adrenergic receptor activity 0005886:plasma membrane 0004930:G protein-coupled receptor activity 0002025:norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure 0007188:adenylate cyclase-modulating G protein-coupled receptor signaling pathway 0071880:adenylate cyclase-activating adrenergic receptor signaling pathway 0043235:receptor complex 0042803:protein homodimerization activity 0007190:activation of adenylate cyclase activity 0005975:carbohydrate metabolic process
PDB	2CDW
Drugbank	DB00571 ; DB06726 ; DB01363 ; DB01288 ; DB01118 ; DB00938 ; DB01365 ; DB08893 ; DB00217 ; DB00785 ; DB00960 ; DB05395 ; DB00182 ; DB06262 ; DB01001 ; DB06190 ; DB04846 ; DB01049 ; DB08808 ; DB00983 ; DB14895 ; DB01064 ; DB00540 ; DB11124 ; DB00726 ; DB00368 ; DB01580 ; DB00334 ; DB01102 ; DB11273 ; DB00866 ; DB08807 ; DB00715 ; DB13345 ; DB04861 ; DB00871 ; DB11278 ; DB01407
KEGG	hsa:155

Type

Detail

Target ID

T79O0V

Protein Name

Beta-3 adrenergic receptor

Uniprot ID

P13945

Protein Name Alias

Beta-3 adrenoreceptor; Beta-3 adrenoceptor

Gene ID

155

Gene Symbol

ADRB3

Gene Alias

ADRB3R; B3AR

TTD

T51408: Successful target

Pfam

PF00001

0043410:positive regulation of MAPK cascade

0051379:epinephrine binding

0120162:positive regulation of cold-induced thermogenesis

0007187:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

0002862:negative regulation of inflammatory response to antigenic stimulus

0005887:integral component of plasma membrane

0006112:energy reserve metabolic process

0007186:G protein-coupled receptor signaling pathway

0006091:generation of precursor metabolites and energy

0004939:beta-adrenergic receptor activity

0015052:beta3-adrenergic receptor activity

0005886:plasma membrane

0004930:G protein-coupled receptor activity

0002025:norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure

0007188:adenylate cyclase-modulating G protein-coupled receptor signaling pathway

0071880:adenylate cyclase-activating adrenergic receptor signaling pathway

0043235:receptor complex

0042803:protein homodimerization activity

0007190:activation of adenylate cyclase activity

0005975:carbohydrate metabolic process

PDB

2CDW

Drugbank

DB00571 ; DB06726 ; DB01363 ; DB01288 ; DB01118 ; DB00938 ; DB01365 ; DB08893 ; DB00217 ; DB00785 ; DB00960 ; DB05395 ; DB00182 ; DB06262 ; DB01001 ; DB06190 ; DB04846 ; DB01049 ; DB08808 ; DB00983 ; DB14895 ; DB01064 ; DB00540 ; DB11124 ; DB00726 ; DB00368 ; DB01580 ; DB00334 ; DB01102 ; DB11273 ; DB00866 ; DB08807 ; DB00715 ; DB13345 ; DB04861 ; DB00871 ; DB11278 ; DB01407

KEGG

hsa:155

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H1127	Guang Shan Zha	广山楂	Chinese hawthorn	Crataegus pinnatifida
H0802	Zhi Geng	枳梗	NA	Citrus aurantium
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0422	Shan Zha Tan	山楂炭	Chinese hawthorn	Crataegus pinnatifida
H0733	Ye Shan Zha	野山楂	nippon bawthorn	Crataegus pinnatifida
H0804	Zhi Ke	枳壳	Seville ora nge unripe fruit	Citrus aurantium
H0088	Ju He	橘核	Tangerine seed	Citrus reticulata
H0805	Zhi Ke Gan Jin Gao	枳壳干浸膏	Seville ora nge unripe fruit	Citrus aurantium
H0244	Mi La	蜜蜡	Bee wax	Apis cerana
H0419	Shan Zha	山楂	Chinese hawthorn	Crataegus pinnatifida
H0420	Shan Zha Chou Gao	山楂稠膏	Chinese hawthorn	Crataegus pinnatifida
H0961	Dang Yao	当药	Chinese swertia	Swertia chinensis
H0813	Zhi Shi	枳实	Seville orange young fruit	Citrus aurantium
H0903	Ci Cai	荠菜	Shepherdspurse	Capsella bursa-pastoris
H0093	Ju Pi	橘皮	Tangerine pericarp	Citrus reticulata
H1040	Feng Mi	蜂蜜	Honey	Apis cerana
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0421	Shan Zha Qing Gao	山楂清膏	Chinese hawthorn	Crataegus pinnatifida
H0758	Cheng Pi	橙皮	Bitter orange	Citrus aurantium
H0166	Long Kui	龙葵	Black nightshade	Solanum nigrum

Target Description

Related Compounds (Total: 2)

Related Herbs (Total: 20)