HIT-result

Target Description

Type	Detail
Target ID	T80Q3D
Protein Name	Granzyme B
Uniprot ID	P10144
Protein Name Alias	EC 3.4.21.79; C11; CTLA-1; Cathepsin G-like 1; CTSGL1; Cytotoxic T-lymphocyte proteinase 2; Lymphocyte protease; Fragmentin-2; Granzyme-2; Human lymphocyte protein; HLP; SECT; T-cell serine protease 1-3E
Gene ID	3002
Gene Symbol	GZMB
Gene Alias	CGL1; CSPB; CTLA1; GRB
TTD	T08298: Research target
Pfam	PF00089
GO	1900740:positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 0070269:pyroptosis 0005634:nucleus 0043231:intracellular membrane-bounded organelle 0006915:apoptotic process 0051603:proteolysis involved in cellular protein catabolic process 0016020:membrane 0004252:serine-type endopeptidase activity 0017148:negative regulation of translation 0005829:cytosol 0008236:serine-type peptidase activity 0019835:cytolysis 0005576:extracellular region 0140507:granzyme-mediated programmed cell death signaling pathway 0001772:immunological synapse 0005737:cytoplasm 0042267:natural killer cell mediated cytotoxicity 0005739:mitochondrion
PDB	1FQ3 ; 1IAU
Drugbank	NA
KEGG	hsa:3002

Type

Detail

Target ID

T80Q3D

Protein Name

Granzyme B

Uniprot ID

P10144

Protein Name Alias

EC 3.4.21.79; C11; CTLA-1; Cathepsin G-like 1; CTSGL1; Cytotoxic T-lymphocyte proteinase 2; Lymphocyte protease; Fragmentin-2; Granzyme-2; Human lymphocyte protein; HLP; SECT; T-cell serine protease 1-3E

Gene ID

3002

Gene Symbol

GZMB

Gene Alias

CGL1; CSPB; CTLA1; GRB

TTD

T08298: Research target

Pfam

PF00089

1900740:positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway

0070269:pyroptosis

0005634:nucleus

0043231:intracellular membrane-bounded organelle

0006915:apoptotic process

0051603:proteolysis involved in cellular protein catabolic process

0016020:membrane

0004252:serine-type endopeptidase activity

0017148:negative regulation of translation

0005829:cytosol

0008236:serine-type peptidase activity

0019835:cytolysis

0005576:extracellular region

0140507:granzyme-mediated programmed cell death signaling pathway

0001772:immunological synapse

0005737:cytoplasm

0042267:natural killer cell mediated cytotoxicity

0005739:mitochondrion

PDB

1FQ3 ; 1IAU

Drugbank

KEGG

hsa:3002

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0925	Da Fu Zi	大腹子	Areca palm	Areca catechu
H0805	Zhi Ke Gan Jin Gao	枳壳干浸膏	Seville ora nge unripe fruit	Citrus aurantium
H0053	Jin Lian Hua	金莲花	Chinese globeflower	Trollius chinensis
H0802	Zhi Geng	枳梗	NA	Citrus aurantium
H1172	Hei Cao Wu	黑草乌	Kusnezoff monkshood root	Radix aconiti kusnezoffii
H1171	He Zi Rou	诃子肉	Medicine terminalia	Terminalia chebula
H0446	Sheng Jiang	生姜	Fresh common ginger	Zingiber officinale
H0618	Cao Wu	草乌	Kusnezoff monkshood root	Aconitum carmichaelii
H0813	Zhi Shi	枳实	Seville orange young fruit	Citrus aurantium
H0547	Cang Qing Guo	藏青果	Myrobalan	Terminalia chebula
H1170	He Zi	诃子	Medicine terminalia	Terminalia chebula
H0758	Cheng Pi	橙皮	Bitter orange	Citrus aurantium
H0804	Zhi Ke	枳壳	Seville ora nge unripe fruit	Citrus aurantium
H0408	Bing Lang	槟榔	Betenutpalm	Areca catechu

Target Description

Related Compounds (Total: 1)

Related Herbs (Total: 14)