HIT-result

Type	Detail
Target ID	T87DGB
Protein Name	Angiopoietin-1 receptor
Uniprot ID	Q02763
Protein Name Alias	EC 2.7.10.1; Endothelial tyrosine kinase; Tunica interna endothelial cell kinase; Tyrosine kinase with Ig and EGF homology domains-2; Tyrosine-protein kinase receptor TEK; Tyrosine-protein kinase receptor TIE-2; hTIE2; p140 TEK; CD antigen CD202b
Gene ID	7010
Gene Symbol	TEK
Gene Alias	TIE2; VMCM; VMCM1
TTD	T92144: Clinical Trial target
Pfam	PF10430 ; PF00041 ; PF07714
GO	0005902:microvillus 0004713:protein tyrosine kinase activity 2000352:negative regulation of endothelial cell apoptotic process 0043410:positive regulation of MAPK cascade 0000165:MAPK cascade 0009986:cell surface 0005524:ATP binding 0043066:negative regulation of apoptotic process 0018108:peptidyl-tyrosine phosphorylation 0038023:signaling receptor activity 0001666:response to hypoxia 0001938:positive regulation of endothelial cell proliferation 0007169:transmembrane receptor protein tyrosine kinase signaling pathway 0050900:leukocyte migration 0007507:heart development 1902533:positive regulation of intracellular signal transduction 0043627:response to estrogen 0001935:endothelial cell proliferation 0001934:positive regulation of protein phosphorylation 0005925:focal adhesion 0019838:growth factor binding 0001525:angiogenesis 0007275:multicellular organism development 2000251:positive regulation of actin cytoskeleton reorganization 0032878:regulation of establishment or maintenance of cell polarity 0060347:heart trabecula formation 0001958:endochondral ossification 0042802:identical protein binding 0046777:protein autophosphorylation 0043434:response to peptide hormone 0005576:extracellular region 0051894:positive regulation of focal adhesion assembly 0043552:positive regulation of phosphatidylinositol 3-kinase activity 0007267:cell-cell signaling 0005886:plasma membrane 0005911:cell-cell junction 0033674:positive regulation of kinase activity 0048014:Tie signaling pathway 0051591:response to cAMP 0060216:definitive hemopoiesis 0005887:integral component of plasma membrane 0016525:negative regulation of angiogenesis 0005737:cytoplasm 0002040:sprouting angiogenesis 0034451:centriolar satellite 0004672:protein kinase activity 0043235:receptor complex 0050728:negative regulation of inflammatory response 0016323:basolateral plasma membrane 0045766:positive regulation of angiogenesis 2000351:regulation of endothelial cell apoptotic process 0045121:membrane raft 0070374:positive regulation of ERK1 and ERK2 cascade 0043114:regulation of vascular permeability 0009925:basal plasma membrane 0034446:substrate adhesion-dependent cell spreading 0014068:positive regulation of phosphatidylinositol 3-kinase signaling 0007165:signal transduction 0010595:positive regulation of endothelial cell migration 0051897:positive regulation of protein kinase B signaling 0072012:glomerulus vasculature development 0004714:transmembrane receptor protein tyrosine kinase activity 0016324:apical plasma membrane
PDB	5MYA ; 2P4I ; 4X3J ; 2WQB ; 4K0V ; 2OSC ; 2GY5 ; 2GY7 ; 3BEA ; 1FVR ; 3L8P ; 5UTK ; 2OO8 ; 6MWE ; 5MYB
Drugbank	DB14840 ; DB08221 ; DB08901 ; DB05294 ; DB08896 ; DB12010 ; DB00415
KEGG	hsa:7010

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Name: shikonin

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0354	Ren Dong Teng	忍冬藤	Japanese honeysuckle vine	Lonicera japonica
H1055	Bai Guo Ren	白果仁	ginkgo	Ginkgo biloba
H0334	Bi Ma Ren	蓖麻仁	Ricinus	Ricinus communis
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0064	Jin Yin Hua	金银花	Japanese honeysuckle	Lonicera japonica
H0358	Ren Shen Ye	人参叶	Ginseng leaf	Panax ginseng
H0750	Yin Xing Ye	银杏叶	Folium ginkgo	Ginkgo biloba
H0340	Bi Ma Zi	蓖麻子	Castorbean seed	Ricinus communis
H0065	Jin Yin Hua Ti Qu Ye	金银花提取液	Japanese honeysuckle	Lonicera japonica
H0416	Shan Shen	山参	NA	Panax ginseng
H0326	Bi Ma Gen	蓖麻根	Castorbean root	Ricinus communis
H0357	Ren Shen	人参	Ginseng	Panax ginseng
H0321	Bi Ma	蓖麻	castor oil plant	Ricinus communis
H1051	Bai Guo	白果	Ginkgo nut	Ginkgo biloba
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens