HIT-result

Type	Detail
Target ID	T90FBZ
Protein Name	Clusterin
Uniprot ID	P10909
Protein Name Alias	Aging-associated gene 4 protein; Apolipoprotein J; Apo-J; Complement cytolysis inhibitor; CLI; Complement-associated protein SP-40,40; Ku70-binding protein 1; NA1/NA2; Sulfated glycoprotein 2; SGP-2; Testosterone-repressed prostate message 2; TRPM-2
Gene ID	1191
Gene Symbol	CLU
Gene Alias	APOJ; CLI; KUB1
TTD	T96669: Research target
Pfam	PF01093
GO	0005102:signaling receptor binding 0005743:mitochondrial inner membrane 0002576:platelet degranulation 0031334:positive regulation of protein-containing complex assembly 0031093:platelet alpha granule lumen 0051082:unfolded protein binding 1905908:positive regulation of amyloid fibril formation 0051787:misfolded protein binding 0070062:extracellular exosome 0097193:intrinsic apoptotic signaling pathway 0001540:amyloid-beta binding 1902949:positive regulation of tau-protein kinase activity 0048260:positive regulation of receptor-mediated endocytosis 0043691:reverse cholesterol transport 1901216:positive regulation of neuron death 0046982:protein heterodimerization activity 0042981:regulation of apoptotic process 0097440:apical dendrite 1902230:negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage 0031333:negative regulation of protein-containing complex assembly 0072562:blood microparticle 0005739:mitochondrion 0051087:chaperone binding 0050821:protein stabilization 0030449:regulation of complement activation 0051092:positive regulation of NF-kappaB transcription factor activity 0048471:perinuclear region of cytoplasm 0044877:protein-containing complex binding 0002434:immune complex clearance 0099020:perinuclear endoplasmic reticulum lumen 0019730:antimicrobial humoral response 0009986:cell surface 1900221:regulation of amyloid-beta clearance 0043231:intracellular membrane-bounded organelle 0006956:complement activation 0061518:microglial cell proliferation 1902430:negative regulation of amyloid-beta formation 2000060:positive regulation of ubiquitin-dependent protein catabolic process 0005615:extracellular space 0032991:protein-containing complex 0043065:positive regulation of apoptotic process 0042127:regulation of cell population proliferation 0061741:chaperone-mediated protein transport involved in chaperone-mediated autophagy 0005794:Golgi apparatus 0005634:nucleus 0048156:tau protein binding 0010628:positive regulation of gene expression 0061740:protein targeting to lysosome involved in chaperone-mediated autophagy 0005737:cytoplasm 0051131:chaperone-mediated protein complex assembly 1901214:regulation of neuron death 0045429:positive regulation of nitric oxide biosynthetic process 0032760:positive regulation of tumor necrosis factor production 0009615:response to virus 0062023:collagen-containing extracellular matrix 0032286:central nervous system myelin maintenance 0090201:negative regulation of release of cytochrome c from mitochondria 1903573:negative regulation of response to endoplasmic reticulum stress 0001836:release of cytochrome c from mitochondria 0097418:neurofibrillary tangle 0006629:lipid metabolic process 0005576:extracellular region 0005829:cytosol 0034366:spherical high-density lipoprotein particle 1905895:negative regulation of cellular response to tunicamycin 0060548:negative regulation of cell death 1902998:positive regulation of neurofibrillary tangle assembly 1902847:regulation of neuronal signal transduction 0045087:innate immune response 0045202:synapse 0000902:cell morphogenesis 0001774:microglial cell activation 1905892:negative regulation of cellular response to thapsigargin 0051788:response to misfolded protein 2001244:positive regulation of intrinsic apoptotic signaling pathway 0017038:protein import 0050750:low-density lipoprotein particle receptor binding 0031625:ubiquitin protein ligase binding 1902004:positive regulation of amyloid-beta formation 1905907:negative regulation of amyloid fibril formation 0061077:chaperone-mediated protein folding 0006958:complement activation, classical pathway 0032436:positive regulation of proteasomal ubiquitin-dependent protein catabolic process 0042583:chromaffin granule
PDB	NA
Drugbank	DB09130 ; DB01593 ; DB14487 ; DB14548 ; DB14533
KEGG	hsa:1191

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Name: Valproic Acid

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens