HIT-result

Target Description

Type	Detail
Target ID	T94RQ2
Protein Name	E3 ubiquitin-protein ligase SIAH1
Uniprot ID	Q8IUQ4
Protein Name Alias	EC 2.3.2.27; RING-type E3 ubiquitin transferase SIAH1; Seven in absentia homolog 1; Siah-1; Siah-1a
Gene ID	6477
Gene Symbol	SIAH1
Gene Alias	HUMSIAH
TTD	NA
Pfam	PF03145
GO	0042802:identical protein binding 0005634:nucleus 0004842:ubiquitin-protein transferase activity 2001244:positive regulation of intrinsic apoptotic signaling pathway 0005829:cytosol 0007399:nervous system development 0006915:apoptotic process 0009653:anatomical structure morphogenesis 0030163:protein catabolic process 0007049:cell cycle 0005737:cytoplasm 0043161:proteasome-mediated ubiquitin-dependent protein catabolic process 0030877:beta-catenin destruction complex 0006511:ubiquitin-dependent protein catabolic process 0031648:protein destabilization 0005886:plasma membrane 1902842:negative regulation of netrin-activated signaling pathway 1990000:amyloid fibril formation 0000209:protein polyubiquitination 0043065:positive regulation of apoptotic process 0051402:neuron apoptotic process 0005769:early endosome 0008270:zinc ion binding 0008022:protein C-terminus binding 0031624:ubiquitin conjugating enzyme binding 0061630:ubiquitin protein ligase activity 0007411:axon guidance 0007283:spermatogenesis
PDB	4I7D ; 4X3G ; 4C9Z ; 5WZZ ; 4I7C ; 2A25 ; 4CA1 ; 4I7B
Drugbank	NA
KEGG	hsa:6477

Type

Detail

Target ID

T94RQ2

Protein Name

E3 ubiquitin-protein ligase SIAH1

Uniprot ID

Q8IUQ4

Protein Name Alias

EC 2.3.2.27; RING-type E3 ubiquitin transferase SIAH1; Seven in absentia homolog 1; Siah-1; Siah-1a

Gene ID

6477

Gene Symbol

SIAH1

Gene Alias

HUMSIAH

TTD

Pfam

PF03145

0042802:identical protein binding

0005634:nucleus

0004842:ubiquitin-protein transferase activity

2001244:positive regulation of intrinsic apoptotic signaling pathway

0005829:cytosol

0007399:nervous system development

0006915:apoptotic process

0009653:anatomical structure morphogenesis

0030163:protein catabolic process

0007049:cell cycle

0005737:cytoplasm

0043161:proteasome-mediated ubiquitin-dependent protein catabolic process

0030877:beta-catenin destruction complex

0006511:ubiquitin-dependent protein catabolic process

0031648:protein destabilization

0005886:plasma membrane

1902842:negative regulation of netrin-activated signaling pathway

1990000:amyloid fibril formation

0000209:protein polyubiquitination

0043065:positive regulation of apoptotic process

0051402:neuron apoptotic process

0005769:early endosome

0008270:zinc ion binding

0008022:protein C-terminus binding

0031624:ubiquitin conjugating enzyme binding

0061630:ubiquitin protein ligase activity

0007411:axon guidance

0007283:spermatogenesis

PDB

4I7D ; 4X3G ; 4C9Z ; 5WZZ ; 4I7C ; 2A25 ; 4CA1 ; 4I7B

Drugbank

KEGG

hsa:6477

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0956	Dang Gui Gan Jin Gao	当归干浸膏	NA	Angelica sinensis
H0416	Shan Shen	山参	NA	Panax ginseng
H0103	Ai Ye	艾叶	Argy wormwood leaf	Artemisia argyi
H0154	Ai Ye You	艾叶油	Argy wormwood leaf	Artemisia argyi
H0357	Ren Shen	人参	Ginseng	Panax ginseng
H0358	Ren Shen Ye	人参叶	Ginseng leaf	Panax ginseng
H0955	Dang Gui	当归	Chinese angelica	Angelica sinensis
H0938	Da Suan	大蒜	Garlic	Allium sativum
H0522	Tai Zi Shen	太子参	Heterophylly falsestarwort root	Radix pseudostellariae
H0173	Lu Hui	芦荟	Kulaso aloe dried juice	Aloe vera
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens

Target Description

Related Compounds (Total: 1)

Related Herbs (Total: 12)