HIT-result

Type	Detail
Target ID	T95B1B
Protein Name	Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
Uniprot ID	P33316
Protein Name Alias	dUTPase; EC 3.6.1.23; dUTP pyrophosphatase
Gene ID	1854
Gene Symbol	DUT
Gene Alias	NA
TTD	T39054: Clinical Trial target
Pfam	PF00692
GO	0070062:extracellular exosome 0042975:peroxisome proliferator activated receptor binding 0005829:cytosol 0042802:identical protein binding 0000287:magnesium ion binding 0043254:regulation of protein-containing complex assembly 0005654:nucleoplasm 0046081:dUTP catabolic process 0014070:response to organic cyclic compound 0006260:DNA replication 0004170:dUTP diphosphatase activity 0003723:RNA binding 0030547:receptor inhibitor activity 0005739:mitochondrion 0015949:nucleobase-containing small molecule interconversion 0005634:nucleus 0001889:liver development 0032556:pyrimidine deoxyribonucleotide binding 0006226:dUMP biosynthetic process 0006139:nucleobase-containing compound metabolic process
PDB	1Q5H ; 5H4J ; 2HQU ; 3ARA ; 3EHW ; 4MZ6 ; 1Q5U ; 3ARN ; 4MZ5
Drugbank	DB03413 ; DB04685
KEGG	hsa:1854

Target Description