HIT-result

Type	Detail
Target ID	T98O63
Protein Name	Histone-lysine N-methyltransferase, H3 lysine-79 specific
Uniprot ID	Q8TEK3
Protein Name Alias	EC 2.1.1.360; DOT1-like protein; Histone H3-K79 methyltransferase; H3-K79-HMTase; Lysine N-methyltransferase 4
Gene ID	84444
Gene Symbol	DOT1L
Gene Alias	KIAA1814; KMT4
TTD	T87686: Clinical Trial target
Pfam	PF08123
GO	0003677:DNA binding 0008134:transcription factor binding 0005634:nucleus 0042054:histone methyltransferase activity 0018024:histone-lysine N-methyltransferase activity 0008284:positive regulation of cell population proliferation 0034729:histone H3-K79 methylation 0000781:chromosome, telomeric region 2000677:regulation of transcription regulatory region DNA binding 0043231:intracellular membrane-bounded organelle 0006281:DNA repair 0010467:gene expression 0032991:protein-containing complex 0006348:chromatin silencing at telomere 0032200:telomere organization 0031151:histone methyltransferase activity (H3-K79 specific) 0005654:nucleoplasm 0000077:DNA damage checkpoint 0045944:positive regulation of transcription by RNA polymerase II 0046425:regulation of receptor signaling pathway via JAK-STAT
PDB	2MV7 ; 5DT2 ; 3SR4 ; 5MW3 ; 5MVS ; 6IN3 ; 6JMA ; 4EKI ; 1NW3 ; 4ER6 ; 3QOX ; 4ER0 ; 6NQA ; 5DTQ ; 4EK9 ; 3SX0 ; 5DRY ; 6J99 ; 4ER7 ; 4EKG ; 5DSX ; 5DTM ; 5DTR ; 3UWP ; 6JN2 ; 6NJ9 ; 6O96 ; 5DRT ; 4ER5 ; 4WVL ; 6TE6 ; 4ER3 ; 3QOW ; 5JUW ; 6NN6 ; 6NOG ; 5MW4 ; 4EQZ ; 6TEN ; 4HRA ; 6TEL ; 6JM9
Drugbank	NA
KEGG	hsa:84444

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Name: S-Adenosyl Methionine

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens