HIT-result

Type	Detail
Target ID	T98SBW
Protein Name	Interleukin-6 receptor subunit alpha
Uniprot ID	P08887
Protein Name Alias	IL-6 receptor subunit alpha; IL-6R subunit alpha; IL-6R-alpha; IL-6RA; IL-6R 1; Membrane glycoprotein 80; gp80; CD antigen CD126
Gene ID	3570
Gene Symbol	IL6R
Gene Alias	NA
TTD	T93440: Successful target
Pfam	PF00047 ; PF09240
GO	0043235:receptor complex 0050829:defense response to Gram-negative bacterium 0043410:positive regulation of MAPK cascade 0072540:T-helper 17 cell lineage commitment 0031018:endocrine pancreas development 0072126:positive regulation of glomerular mesangial cell proliferation 0070102:interleukin-6-mediated signaling pathway 0032966:negative regulation of collagen biosynthetic process 0016324:apical plasma membrane 0006953:acute-phase response 0008284:positive regulation of cell population proliferation 0032755:positive regulation of interleukin-6 production 0070120:ciliary neurotrophic factor-mediated signaling pathway 0002446:neutrophil mediated immunity 0002384:hepatic immune response 0005615:extracellular space 0005896:interleukin-6 receptor complex 0070110:ciliary neurotrophic factor receptor complex 0032722:positive regulation of chemokine production 0005886:plasma membrane 0050731:positive regulation of peptidyl-tyrosine phosphorylation 0019899:enzyme binding 0004921:interleukin-11 receptor activity 0032717:negative regulation of interleukin-8 production 0002548:monocyte chemotaxis 0048661:positive regulation of smooth muscle cell proliferation 0019970:interleukin-11 binding 0097191:extrinsic apoptotic signaling pathway 0042531:positive regulation of tyrosine phosphorylation of STAT protein 0019981:interleukin-6 binding 0045669:positive regulation of osteoblast differentiation 0005576:extracellular region 0070119:ciliary neurotrophic factor binding 0019955:cytokine binding 0010536:positive regulation of activation of Janus kinase activity 0042803:protein homodimerization activity 0050830:defense response to Gram-positive bacterium 0010573:vascular endothelial growth factor production 0004915:interleukin-6 receptor activity 0004896:cytokine receptor activity 0019221:cytokine-mediated signaling pathway 0034097:response to cytokine 0002690:positive regulation of leukocyte chemotaxis 0009897:external side of plasma membrane
PDB	1P9M ; 5FUC ; 1N26 ; 1N2Q ; 2ARW ; 7DC8
Drugbank	DB11767 ; DB06273 ; DB15762
KEGG	hsa:3570

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Name: Alcohol

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0956	Dang Gui Gan Jin Gao	当归干浸膏	NA	Angelica sinensis
H0416	Shan Shen	山参	NA	Panax ginseng
H0103	Ai Ye	艾叶	Argy wormwood leaf	Artemisia argyi
H0154	Ai Ye You	艾叶油	Argy wormwood leaf	Artemisia argyi
H0357	Ren Shen	人参	Ginseng	Panax ginseng
H0358	Ren Shen Ye	人参叶	Ginseng leaf	Panax ginseng
H0955	Dang Gui	当归	Chinese angelica	Angelica sinensis
H0938	Da Suan	大蒜	Garlic	Allium sativum
H0522	Tai Zi Shen	太子参	Heterophylly falsestarwort root	Radix pseudostellariae
H0173	Lu Hui	芦荟	Kulaso aloe dried juice	Aloe vera
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens