Compound Description
| ID: C0119 | Common name: Hesperidin |
| IUPAC: (2S)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxy-2,3-dihydrochromen-4-one | CAS: CAS:520-26-3 |
| Chembl ID: CHEMBL449317 | Pubchem ID: CID:10621 |
| Formula: C28H34O15 | TCM-ID: TCMC1321 |
| Smiles: CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3=CC(=C4C(=O)CC(OC4=C3)C5=CC(=C(C=C5)OC)O)O)O)O)O)O)O)O | |
| Alias:
4H-1-Benzopyran-4-one, 7-[[6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-, (S)-;
Flavanone, 3',5,7-trihydroxy-4'-methoxy-, 7-(6-O-α-L-rhamnosyl-D-glucoside); Hesperidin; (2S)-7-[[6-O-(6-Deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one; (2S)-Hesperidin; Atripliside B; Cirantin; Hesperetin 7-O-rutinoside; Hesperetin 7-rhamnoglucoside; Hesperetin 7-rutinoside; Hesperidine; Hesperidoside; Hesperitin 7-O-rutinoside; NSC 44184 |
Structure:
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Related Targets (Total: 11)
| Target id | Protein Name | Gene Symbol | Uniprot ID | Target Level | No.of Literature Evidence |
|---|---|---|---|---|---|
| T96N1K | Calcium/calmodulin-dependent protein kinase type IV | CAMK4 |
Q16566 |
A | 1 Reference(s) |
| T04H8Y | Beta-secretase 1 | BACE1 |
P56817 |
A | 1 Reference(s) |
| T10HL8 | Intercellular adhesion molecule 1 | ICAM1 |
P05362 |
B | 1 Reference(s) |
| T59IKQ | Vascular cell adhesion protein 1 | VCAM1 |
P19320 |
B | 1 Reference(s) |
| T80TUC | Apoptosis regulator BAX | BAX |
Q07812 |
B | 1 Reference(s) |
| T85U8U | Caspase-3 | CASP3 |
P42574 |
B | 1 Reference(s) |
| T71K92 | Apoptosis regulator Bcl-2 | BCL2 |
P10415 |
C | 1 Reference(s) |
| T09H2Z | Nitric oxide synthase, inducible | NOS2 |
P35228 |
C | 1 Reference(s) |
| T23VMI | Tumor necrosis factor | TNF |
P01375 |
C | 1 Reference(s) |
| T09KQF | Proliferating cell nuclear antigen | PCNA |
P12004 |
C | 1 Reference(s) |
| T06RMZ | Nuclear factor NF-kappa-B p105 subunit | NFKB1 |
P19838 |
C | 1 Reference(s) |
*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Related Herbs (Total: 42)
| Herb id | Chinese Pin Yin | Chinese Character | English Name | Latin Name |
|---|---|---|---|---|
| H0314 | Pu Gong Ying | 蒲公英 | Mongolian dandelion | Taraxacum mongolicum |
| H0663 | Xiao Ji | 小蓟 | Setose thistle | Cirsium setosum |
| H0092 | Ju Hua | 菊花 | Florists chrysanthemum flower | Chrysanthemum morifolium |
| H0651 | Xiang Yuan | 香橼 | Wilson citron | Citrus medica |
| H1225 | Huai Mi | 槐米 | NA | Sophora japonica |
| H0805 | Zhi Ke Gan Jin Gao | 枳壳干浸膏 | Seville ora nge unripe fruit | Citrus aurantium |
| H0315 | Pu Gong Ying Jin Gao | 蒲公英浸膏 | Mongolian dandelion | Taraxacum mongolicum |
| H0758 | Cheng Pi | 橙皮 | Bitter orange | Citrus aurantium |
| H1224 | Huai Jiao | 槐角 | pod of japanese pagodatree | Sophora japonica |
| H1161 | Hang Ju | 杭菊 | Chrysanthemum flower | Chrysanthemum morifolium |
| H0604 | Wu Wei Teng | 五味藤 | NA | Securidaca inappendiculata |
| H0072 | Jing Jie | 荆芥 | Fineleaf schizonepeta | Schizonepeta tenuifolia |
| H1222 | Huai Hua | 槐花 | flower bud of japanese pagodatree | Sophora japonica |
| H0074 | Jing Jie Tan | 荆芥炭 | NA | Schizonepetae herba |
| H0195 | Ma Chi Xian | 马齿苋 | Purslane | Portulaca oleracea |
| H1217 | Bai Mei Hua | 白梅花 | Japanese apricot flower | Prunus mume |
| H0472 | Shu Da Huang | 熟大黄 | NA | Rheum palmatum |
| H0804 | Zhi Ke | 枳壳 | Seville ora nge unripe fruit | Citrus aurantium |
| H0802 | Zhi Geng | 枳梗 | NA | Citrus aurantium |
| H0927 | Da Huang Jin Gao | 大黄浸膏 | Medicinal rhubarb | Rheum officinale |
| H1214 | Hua Jiao | 花椒 | Bunge pricklyash | Zanthoxylum bungeanum |
| H1124 | Guang Jin Qian Cao | 广金钱草 | Snowbellleaf tickclover | Desmodium styracifolium |
| H0960 | Dang Shen Qing Gao | 党参清膏 | Root of hairy asiabell | Codonopsis pilosula |
| H0652 | Xiang Yuan Pi | 香橼皮 | Wilson citron | Citrus medica |
| H0602 | Wu Mei Rou | 乌梅肉 | Ebony | Prunus mume |
| H0073 | Jing Jie Sui | 荆芥穗 | NA | Schizonepetae spica |
| H1227 | Huai Zhi | 槐枝 | NA | Sophora japonica |
| H0958 | Dang Shen | 党参 | Pilose asiabell | Codonopsis pilosula |
| H0926 | Da Huang | 大黄 | Medicinal rhubarb | Rheum officinale |
| H0601 | Wu Mei | 乌梅 | Japanese apricot | Prunus mume |
| H0920 | Da Ban Bian Lian | 大半边莲 | Asian lobelia | Lobelia chinensis |
| H0088 | Ju He | 橘核 | Tangerine seed | Citrus reticulata |
| H0766 | Yu Zhu | 玉竹 | NA | Polygonatum odoratum |
| H0164 | Ban Zhi Lian | 半枝莲 | Barbed skullcap | Scutellaria barbata |
| H1244 | Huang Miao | 黄苗 | NA | Taraxacum mongolicum |
| H0093 | Ju Pi | 橘皮 | Tangerine pericarp | Citrus reticulata |
| H0961 | Dang Yao | 当药 | Chinese swertia | Swertia chinensis |
| H0233 | Mao Liang Mian Zhen | 毛两面针 | NA | Zanthoxylum nitidum |
| H0113 | Ban Bian Lian | 半边莲 | Chinese lobelia | Lobelia chinensis |
| H0928 | Da Huang Liu Jin Gao | 大黄流浸膏 | Medicinal rhubarb | Rheum officinale |
| H0813 | Zhi Shi | 枳实 | Seville orange young fruit | Citrus aurantium |
| H0139 | Lian Qiao | 连翘 | Weeping forsythia | Forsythia suspensa |
Ckey description of the interaction between compound and target