Compound Description

ID:   C0404 Common name:   Silybin B
IUPAC:  (2R,3R)-3,5,7-trihydroxy-2-[(2S,3S)-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-2,3-dihydrochromen-4-one CAS:  CAS:142797-34-0
Chembl ID:   CHEMBL592675 Pubchem ID:   CID:1548994
Formula:  C25H22O10 TCM-ID:  TCMC2080
Smiles:  COC1=C(C=CC(=C1)C2C(OC3=C(O2)C=C(C=C3)C4C(C(=O)C5=C(C=C(C=C5O4)O)O)O)CO)O
Alias:

(2R,3R)-2-[(2S,3S)-2,3-Dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-1,4-benzodioxin-6-yl]-2,3-dihydro-3,5,7-trihydroxy-4H-1-benzopyran-4-one;

1,4-Benzodioxin, 4H-1-benzopyran-4-one deriv.;

NSC 227190;

Silibinin B;

Silybin B;

Silybin a1
Structure:

Related Targets  (Total: 32)

Target idProtein NameGene SymbolUniprot IDTarget LevelNo.of Literature Evidence
T60QJ3 ATP-binding cassette sub-family B member 5ABCB5 Q2M3G0
A 1 Reference(s)
T93SFQ NAD-dependent protein deacetylase sirtuin-1SIRT1 Q96EB6
A 1 Reference(s)
T16A2X CatalaseCAT P04040
A 1 Reference(s)
T30D9G Superoxide dismutase [Cu-Zn]SOD1 P00441
A 1 Reference(s)
T30VNV MyeloperoxidaseMPO P05164
A 1 Reference(s)
T44LWL Transcription factor p65RELA Q04206
A 1 Reference(s)
T07TMB Cyclin-dependent kinase 1CDK1 P06493
A 1 Reference(s)
T29MD1 Mitogen-activated protein kinase 8MAPK8 P45983
A 1 Reference(s)
T85AXP Cytochrome P450 3A4CYP3A4 P08684
A 1 Reference(s)
T05O6O Estrogen receptor betaESR2 Q92731
A 1 Reference(s)
T36B1Q Baculoviral IAP repeat-containing protein 5BIRC5 O15392
C 1 Reference(s)
T93WZG G1/S-specific cyclin-D1CCND1 P24385
C 1 Reference(s)
T50V79 Interleukin-4IL4 P05112
C 1 Reference(s)
T08Q7W Prostaglandin G/H synthase 2PTGS2 P35354
C 1 Reference(s)
T10HL8 Intercellular adhesion molecule 1ICAM1 P05362
C 1 Reference(s)
T24U57 E-selectinSELE P16581
C 1 Reference(s)
T54CIF Interleukin-8CXCL8 P10145
C 1 Reference(s)
T64BTV Interleukin-1 betaIL1B P01584
C 1 Reference(s)
T23VMI Tumor necrosis factorTNF P01375
C 1 Reference(s)
T30KQB Alanine aminotransferase 1GPT P24298
C 1 Reference(s)
T42EAZ Vascular endothelial growth factor AVEGFA P15692
C 1 Reference(s)
T14XGP Protocadherin alpha-C2PCDHAC2 Q9Y5I4
C 1 Reference(s)
T24LXT G2/mitotic-specific cyclin-B1CCNB1 P14635
C 1 Reference(s)
T86UXL Cyclin-A2CCNA2 P20248
C 1 Reference(s)
T31EJG Apoptotic protease-activating factor 1APAF1 O14727
C 1 Reference(s)
T71K92 Apoptosis regulator Bcl-2BCL2 P10415
C 1 Reference(s)
T74I49 Bcl-2-like protein 1BCL2L1 Q07817
C 1 Reference(s)
T80TUC Apoptosis regulator BAXBAX Q07812
C 1 Reference(s)
T85U8U Caspase-3CASP3 P42574
C 1 Reference(s)
T34DZ7 Interleukin-2IL2 P60568
C 1 Reference(s)
T28DIY Immunoglobulin heavy constant epsilonIGHE P01854
C 1 Reference(s)
T87JTM SialinSLC17A5 Q9NRA2
C 1 Reference(s)

*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".

Related Herbs  (Total: 1)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0484 Shui Fei Ji水飞蓟 St marysSilybum marianum