Target Description

Type Detail
Target ID T06KGA
Protein Name Integrin alpha-4
Uniprot ID P13612
Protein Name Alias CD49 antigen-like family member D;  Integrin alpha-IV;  VLA-4 subunit alpha;  CD antigen CD49d
Gene ID 3676
Gene Symbol ITGA4
Gene Alias CD49D
TTD T97587: Successful target
Pfam PF08441 ; PF01839
GO
0034668:integrin alpha4-beta1 complex

0090074:negative regulation of protein homodimerization activity

0046872:metal ion binding

1990405:protein antigen binding

0009986:cell surface

0007159:leukocyte cell-cell adhesion

0016020:membrane

0140039:cell-cell adhesion in response to extracellular stimulus

0071345:cellular response to cytokine stimulus

1990771:clathrin-dependent extracellular exosome endocytosis

0001968:fibronectin binding

0043113:receptor clustering

0034669:integrin alpha4-beta7 complex

0034446:substrate adhesion-dependent cell spreading

1904646:cellular response to amyloid-beta

0050900:leukocyte migration

0060385:axonogenesis involved in innervation

0003366:cell-matrix adhesion involved in ameboidal cell migration

0007229:integrin-mediated signaling pathway

0070062:extracellular exosome

0098657:import into cell

0007160:cell-matrix adhesion

0035987:endodermal cell differentiation

0050776:regulation of immune response

0015026:coreceptor activity

0050839:cell adhesion molecule binding

0030198:extracellular matrix organization

0005925:focal adhesion

0034113:heterotypic cell-cell adhesion

0033631:cell-cell adhesion mediated by integrin

1905564:positive regulation of vascular endothelial cell proliferation

2000353:positive regulation of endothelial cell apoptotic process

0050901:leukocyte tethering or rolling

0030426:growth cone

0043025:neuronal cell body

0005178:integrin binding

0005886:plasma membrane

1990138:neuron projection extension

0050904:diapedesis

0030183:B cell differentiation

1903238:positive regulation of leukocyte tethering or rolling

2000406:positive regulation of T cell migration

PDB 3V4V ; 4HKC ; 5FPI ; 5C7Z ; 3V4P
Drugbank DB05468 ; DB05122 ; DB05092 ; DB06822 ; DB00108 ; DB09033 ; DB15791 ; DB04997
KEGG hsa:3676

Related Compounds  (Total: 3)

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C0872
Name: Allicin
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C1113
Name: heparin
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C1134
Name: gambogic acid


Related Herbs  (Total: 6)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0938 Da Suan大蒜 GarlicAllium sativum
H0915 Cong Bai葱白 Fistular onionAllium fistulosum
H0916 Cong Tou葱头 Allium bulb, wild scallion, chinese green onionBulbus allii fistulosi
H0914 Cong Allium bulb, wild scallion, chinese green onionBulbus allii fistulosi
H0669 Xie Bai薤白 Longstamen onionAllium macrostemon
H0499 Si Ji Cong Tou四季葱头 Allium bulb, wild scallion, chinese green onionBulbus allii fistulosi