HIT-result

Type	Detail
Target ID	T06KGA
Protein Name	Integrin alpha-4
Uniprot ID	P13612
Protein Name Alias	CD49 antigen-like family member D; Integrin alpha-IV; VLA-4 subunit alpha; CD antigen CD49d
Gene ID	3676
Gene Symbol	ITGA4
Gene Alias	CD49D
TTD	T97587: Successful target
Pfam	PF08441 ; PF01839
GO	0034668:integrin alpha4-beta1 complex 0090074:negative regulation of protein homodimerization activity 0046872:metal ion binding 1990405:protein antigen binding 0009986:cell surface 0007159:leukocyte cell-cell adhesion 0016020:membrane 0140039:cell-cell adhesion in response to extracellular stimulus 0071345:cellular response to cytokine stimulus 1990771:clathrin-dependent extracellular exosome endocytosis 0001968:fibronectin binding 0043113:receptor clustering 0034669:integrin alpha4-beta7 complex 0034446:substrate adhesion-dependent cell spreading 1904646:cellular response to amyloid-beta 0050900:leukocyte migration 0060385:axonogenesis involved in innervation 0003366:cell-matrix adhesion involved in ameboidal cell migration 0007229:integrin-mediated signaling pathway 0070062:extracellular exosome 0098657:import into cell 0007160:cell-matrix adhesion 0035987:endodermal cell differentiation 0050776:regulation of immune response 0015026:coreceptor activity 0050839:cell adhesion molecule binding 0030198:extracellular matrix organization 0005925:focal adhesion 0034113:heterotypic cell-cell adhesion 0033631:cell-cell adhesion mediated by integrin 1905564:positive regulation of vascular endothelial cell proliferation 2000353:positive regulation of endothelial cell apoptotic process 0050901:leukocyte tethering or rolling 0030426:growth cone 0043025:neuronal cell body 0005178:integrin binding 0005886:plasma membrane 1990138:neuron projection extension 0050904:diapedesis 0030183:B cell differentiation 1903238:positive regulation of leukocyte tethering or rolling 2000406:positive regulation of T cell migration
PDB	3V4V ; 4HKC ; 5FPI ; 5C7Z ; 3V4P
Drugbank	DB05468 ; DB05122 ; DB05092 ; DB06822 ; DB00108 ; DB09033 ; DB15791 ; DB04997
KEGG	hsa:3676

Go to browser

Name: Allicin

Go to browser

Name: heparin

Go to browser

Name: gambogic acid

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0914	Cong	葱	Allium bulb, wild scallion, chinese green onion	Bulbus allii fistulosi
H0915	Cong Bai	葱白	Fistular onion	Allium fistulosum
H0916	Cong Tou	葱头	Allium bulb, wild scallion, chinese green onion	Bulbus allii fistulosi
H0669	Xie Bai	薤白	Longstamen onion	Allium macrostemon
H0938	Da Suan	大蒜	Garlic	Allium sativum
H0499	Si Ji Cong Tou	四季葱头	Allium bulb, wild scallion, chinese green onion	Bulbus allii fistulosi