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Target Description
Type
Detail
Target ID
T11BL5
Protein Name
Serine/threonine-protein kinase Chk1
Uniprot ID
O14757
Protein Name Alias
EC 2.7.11.1; CHK1 checkpoint homolog; Cell cycle checkpoint kinase; Checkpoint kinase-1
Gene ID
1111
Gene Symbol
CHEK1
Gene Alias
CHK1
TTD
T62449: Clinical Trial target
Pfam
PF00069
GO
0005524:ATP binding
0035402:histone kinase activity (H3-T11 specific)
0004672:protein kinase activity
0106310:protein serine kinase activity
0045839:negative regulation of mitotic nuclear division
0000794:condensed nuclear chromosome
0019904:protein domain specific binding
0018107:peptidyl-threonine phosphorylation
0000077:DNA damage checkpoint
0070317:negative regulation of G0 to G1 transition
0005654:nucleoplasm
0005813:centrosome
0000785:chromatin
0006281:DNA repair
0071260:cellular response to mechanical stimulus
0006260:DNA replication
0044818:mitotic G2/M transition checkpoint
0004674:protein serine/threonine kinase activity
0035556:intracellular signal transduction
0046602:regulation of mitotic centrosome separation
0043231:intracellular membrane-bounded organelle
0005829:cytosol
0005615:extracellular space
0006468:protein phosphorylation
0010767:regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
0006974:cellular response to DNA damage stimulus
0032991:protein-containing complex
0106311:protein threonine kinase activity
0090399:replicative senescence
1901796:regulation of signal transduction by p53 class mediator
0006915:apoptotic process
0010569:regulation of double-strand break repair via homologous recombination
2000615:regulation of histone H3-K9 acetylation
0045787:positive regulation of cell cycle
0005634:nucleus
0006975:DNA damage induced protein phosphorylation
0005737:cytoplasm
0048096:chromatin-mediated maintenance of transcription
0072425:signal transduction involved in G2 DNA damage checkpoint
PDB
2C3K
;
2C3L
;
2YER
;
3U9N
;
2XF0
;
5OOP
;
5OP2
;
1ZLT
;
2GDO
;
4RVK
;
3F9N
;
3PA5
;
4FT7
;
4FT5
;
5OQ7
;
3TKH
;
2C3J
;
4RVL
;
3JVS
;
4FSR
;
2X8I
;
2E9P
;
2CGV
;
5WI2
;
2YDJ
;
2WMV
;
3JVR
;
2WMX
;
2QHN
;
4QYF
;
4FTI
;
2CGX
;
4FTK
;
4QYG
;
1IA8
;
3PA4
;
4FSQ
;
2E9O
;
2HXL
;
5OPB
;
2BRM
;
2E9V
;
2YDK
;
2HXQ
;
5F4N
;
2YM6
;
2BRB
;
4FTQ
;
5OPR
;
2E9U
;
3OT8
;
4FTL
;
3PA3
;
5OP5
;
2WMQ
;
4FT3
;
4FTM
;
1NVR
;
2WMT
;
2WMR
;
5OP4
;
2YM5
;
4FSW
;
4FTT
;
1NVQ
;
2XEY
;
2E9N
;
4JIK
;
4FTC
;
4FSU
;
2QHM
;
2YDI
;
4RVM
;
5DLS
;
2BRG
;
4FSM
;
4QYH
;
2HOG
;
4QYE
;
2YM3
;
4FTJ
;
4FTR
;
4FSN
;
3NLB
;
3TKI
;
5OOR
;
2XEZ
;
4FTU
;
2BR1
;
4HYI
;
2R0U
;
4FT9
;
2YEX
;
2YM4
;
4FTO
;
2CGW
;
5OOT
;
2GHG
;
5OPV
;
4FSY
;
2WMS
;
2BRO
;
1ZYS
;
6FCK
;
2YWP
;
6FCF
;
2BRH
;
2AYP
;
2WMU
;
1NVS
;
4FTA
;
2HY0
;
4GH2
;
4FTN
;
2X8E
;
2WMW
;
5OQ5
;
4HYH
;
2BRN
;
5OPS
;
4FST
;
2CGU
;
5OP7
;
5OPU
;
5OQ8
;
6FC8
;
4FT0
;
3OT3
;
5OQ6
;
2YM8
;
4FSZ
;
2YM7
;
2X8D
Drugbank
DB06852
;
DB07320
;
DB08781
;
DB08778
;
DB06486
;
DB08777
;
DB08393
;
DB07647
;
DB06876
;
DB08774
;
DB07648
;
DB07243
;
DB07654
;
DB05149
;
DB08392
;
DB07213
;
DB07075
;
DB08683
;
DB08780
;
DB08779
;
DB07158
;
DB07655
;
DB07025
;
DB07311
;
DB12010
;
DB07959
;
DB07037
;
DB07653
;
DB07314
;
DB07228
;
DB07034
;
DB07078
;
DB08776
;
DB07336
;
DB07038
KEGG
hsa:1111
Related Compounds (Total: 1)
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C0461
Name: Triptolide
Related Herbs (Total: 1)
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Herb id
Chinese Pin Yin
Chinese Character
English Name
Latin Name
H0118
Kun Ming Shan Hai Tang
昆明山海棠
Glaucousback threewingnut
Tripterygium hypoglaucum