Target Description

Type Detail
Target ID T11BL5
Protein Name Serine/threonine-protein kinase Chk1
Uniprot ID O14757
Protein Name Alias EC 2.7.11.1;  CHK1 checkpoint homolog;  Cell cycle checkpoint kinase;  Checkpoint kinase-1
Gene ID 1111
Gene Symbol CHEK1
Gene Alias CHK1
TTD T62449: Clinical Trial target
Pfam PF00069
GO
0005524:ATP binding

0035402:histone kinase activity (H3-T11 specific)

0004672:protein kinase activity

0106310:protein serine kinase activity

0045839:negative regulation of mitotic nuclear division

0000794:condensed nuclear chromosome

0019904:protein domain specific binding

0018107:peptidyl-threonine phosphorylation

0000077:DNA damage checkpoint

0070317:negative regulation of G0 to G1 transition

0005654:nucleoplasm

0005813:centrosome

0000785:chromatin

0006281:DNA repair

0071260:cellular response to mechanical stimulus

0006260:DNA replication

0044818:mitotic G2/M transition checkpoint

0004674:protein serine/threonine kinase activity

0035556:intracellular signal transduction

0046602:regulation of mitotic centrosome separation

0043231:intracellular membrane-bounded organelle

0005829:cytosol

0005615:extracellular space

0006468:protein phosphorylation

0010767:regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage

0006974:cellular response to DNA damage stimulus

0032991:protein-containing complex

0106311:protein threonine kinase activity

0090399:replicative senescence

1901796:regulation of signal transduction by p53 class mediator

0006915:apoptotic process

0010569:regulation of double-strand break repair via homologous recombination

2000615:regulation of histone H3-K9 acetylation

0045787:positive regulation of cell cycle

0005634:nucleus

0006975:DNA damage induced protein phosphorylation

0005737:cytoplasm

0048096:chromatin-mediated maintenance of transcription

0072425:signal transduction involved in G2 DNA damage checkpoint

PDB 2C3K ; 2C3L ; 2YER ; 3U9N ; 2XF0 ; 5OOP ; 5OP2 ; 1ZLT ; 2GDO ; 4RVK ; 3F9N ; 3PA5 ; 4FT7 ; 4FT5 ; 5OQ7 ; 3TKH ; 2C3J ; 4RVL ; 3JVS ; 4FSR ; 2X8I ; 2E9P ; 2CGV ; 5WI2 ; 2YDJ ; 2WMV ; 3JVR ; 2WMX ; 2QHN ; 4QYF ; 4FTI ; 2CGX ; 4FTK ; 4QYG ; 1IA8 ; 3PA4 ; 4FSQ ; 2E9O ; 2HXL ; 5OPB ; 2BRM ; 2E9V ; 2YDK ; 2HXQ ; 5F4N ; 2YM6 ; 2BRB ; 4FTQ ; 5OPR ; 2E9U ; 3OT8 ; 4FTL ; 3PA3 ; 5OP5 ; 2WMQ ; 4FT3 ; 4FTM ; 1NVR ; 2WMT ; 2WMR ; 5OP4 ; 2YM5 ; 4FSW ; 4FTT ; 1NVQ ; 2XEY ; 2E9N ; 4JIK ; 4FTC ; 4FSU ; 2QHM ; 2YDI ; 4RVM ; 5DLS ; 2BRG ; 4FSM ; 4QYH ; 2HOG ; 4QYE ; 2YM3 ; 4FTJ ; 4FTR ; 4FSN ; 3NLB ; 3TKI ; 5OOR ; 2XEZ ; 4FTU ; 2BR1 ; 4HYI ; 2R0U ; 4FT9 ; 2YEX ; 2YM4 ; 4FTO ; 2CGW ; 5OOT ; 2GHG ; 5OPV ; 4FSY ; 2WMS ; 2BRO ; 1ZYS ; 6FCK ; 2YWP ; 6FCF ; 2BRH ; 2AYP ; 2WMU ; 1NVS ; 4FTA ; 2HY0 ; 4GH2 ; 4FTN ; 2X8E ; 2WMW ; 5OQ5 ; 4HYH ; 2BRN ; 5OPS ; 4FST ; 2CGU ; 5OP7 ; 5OPU ; 5OQ8 ; 6FC8 ; 4FT0 ; 3OT3 ; 5OQ6 ; 2YM8 ; 4FSZ ; 2YM7 ; 2X8D
Drugbank DB06852 ; DB07320 ; DB08781 ; DB08778 ; DB06486 ; DB08777 ; DB08393 ; DB07647 ; DB06876 ; DB08774 ; DB07648 ; DB07243 ; DB07654 ; DB05149 ; DB08392 ; DB07213 ; DB07075 ; DB08683 ; DB08780 ; DB08779 ; DB07158 ; DB07655 ; DB07025 ; DB07311 ; DB12010 ; DB07959 ; DB07037 ; DB07653 ; DB07314 ; DB07228 ; DB07034 ; DB07078 ; DB08776 ; DB07336 ; DB07038
KEGG hsa:1111

Related Compounds  (Total: 1)

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C0461
Name: Triptolide


Related Herbs  (Total: 1)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0118 Kun Ming Shan Hai Tang昆明山海棠 Glaucousback threewingnutTripterygium hypoglaucum