HIT-result

Type	Detail
Target ID	T14BVD
Protein Name	Protein arginine N-methyltransferase 5
Uniprot ID	O14744
Protein Name Alias	PRMT5; EC 2.1.1.320; 72 kDa ICln-binding protein; Histone-arginine N-methyltransferase PRMT5; Jak-binding protein 1; Shk1 kinase-binding protein 1 homolog; SKB1 homolog; SKB1Hs
Gene ID	10419
Gene Symbol	PRMT5
Gene Alias	HRMT1L5; IBP72; JBP1; SKB1
TTD	T82665: Clinical Trial target
Pfam	PF17285 ; PF05185 ; PF17286
GO	0000785:chromatin 0070888:E-box binding 0003714:transcription corepressor activity 0018216:peptidyl-arginine methylation 0000387:spliceosomal snRNP assembly 0008469:histone-arginine N-methyltransferase activity 0007088:regulation of mitotic nuclear division 0035097:histone methyltransferase complex 0005654:nucleoplasm 0016274:protein-arginine N-methyltransferase activity 0045596:negative regulation of cell differentiation 0097421:liver regeneration 0035243:protein-arginine omega-N symmetric methyltransferase activity 0043021:ribonucleoprotein complex binding 0005829:cytosol 0070372:regulation of ERK1 and ERK2 cascade 0006353:DNA-templated transcription, termination 0042118:endothelial cell activation 1904992:positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway 0043985:histone H4-R3 methylation 0034709:methylosome 0008327:methyl-CpG binding 0044030:regulation of DNA methylation 0032922:circadian regulation of gene expression 0090161:Golgi ribbon formation 0046982:protein heterodimerization activity 0048714:positive regulation of oligodendrocyte differentiation 1901796:regulation of signal transduction by p53 class mediator 0008168:methyltransferase activity 0006355:regulation of transcription, DNA-templated 0035246:peptidyl-arginine N-methylation 0005794:Golgi apparatus 0005634:nucleus 0042802:identical protein binding 0002039:p53 binding 0034969:histone arginine methylation 0005737:cytoplasm 0044020:histone methyltransferase activity (H4-R3 specific)
PDB	4GQB ; 6V0P ; 6RLL ; 5EML ; 5EMM ; 5EMK ; 4X60 ; 4X63 ; 6V0O ; 4X61 ; 6UGH ; 5EMJ ; 5C9Z ; 5FA5 ; 6RLQ ; 6CKC ; 6K1S ; 6UXY ; 6UXX ; 6V0N
Drugbank	NA
KEGG	hsa:10419

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Name: Methylthioadenosine

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0338	Qing Ban Xia	清半夏	Ternate pinellia	Pinellia ternata
H0242	Bei Sha Shen Liu Jin Gao	北沙参流浸膏	Glehnia littoralis	Glehnia littoralis
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0439	Sheng Ban Xia	生半夏	Ternate pinellia	Pinellia ternata
H0155	Ban Xia	半夏	Ternate pinellia	Pinellia ternata
H0239	Bei Sha Shen	北沙参	Coastal glehnia	Glehnia littoralis
H0159	Ban Xia Qu	半夏曲	Pinellia tuber leaven	Pinellia ternata
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens