Target Description

Type Detail
Target ID T20FRX
Protein Name Protein S100-A8
Uniprot ID P05109
Protein Name Alias Calgranulin-A;  Calprotectin L1L subunit;  Cystic fibrosis antigen;  CFAG;  Leukocyte L1 complex light chain;  Migration inhibitory factor-related protein 8;  MRP-8;  p8;  S100 calcium-binding protein A8;  Urinary stone protein band A
Gene ID 6279
Gene Symbol S100A8
Gene Alias CAGA;  CFAG;  MRP8
TTD T27402: Research target
Pfam PF01023
GO
0005634:nucleus

0018119:peptidyl-cysteine S-nitrosylation

2001244:positive regulation of intrinsic apoptotic signaling pathway

0070062:extracellular exosome

0002793:positive regulation of peptide secretion

0005829:cytosol

0051493:regulation of cytoskeleton organization

0035425:autocrine signaling

0006915:apoptotic process

0051092:positive regulation of NF-kappaB transcription factor activity

0008017:microtubule binding

0005509:calcium ion binding

0002224:toll-like receptor signaling pathway

0005615:extracellular space

0019730:antimicrobial humoral response

0070488:neutrophil aggregation

0002544:chronic inflammatory response

0005886:plasma membrane

0006914:autophagy

0050786:RAGE receptor binding

0005856:cytoskeleton

0043312:neutrophil degranulation

0050729:positive regulation of inflammatory response

0050832:defense response to fungus

0014002:astrocyte development

0006954:inflammatory response

0035662:Toll-like receptor 4 binding

0002526:acute inflammatory response

0062023:collagen-containing extracellular matrix

0005576:extracellular region

0008270:zinc ion binding

0030307:positive regulation of cell growth

0010043:response to zinc ion

0048306:calcium-dependent protein binding

0045471:response to ethanol

0006919:activation of cysteine-type endopeptidase activity involved in apoptotic process

0032496:response to lipopolysaccharide

0032119:sequestering of zinc ion

0034774:secretory granule lumen

0042060:wound healing

0042742:defense response to bacterium

0045111:intermediate filament cytoskeleton

0050544:arachidonic acid binding

0030593:neutrophil chemotaxis

0002523:leukocyte migration involved in inflammatory response

0045087:innate immune response

PDB 5W1F ; 6DS2 ; 4GGF ; 5HLO ; 1XK4 ; 1MR8 ; 4XJK ; 5HLV
Drugbank DB01593 ; DB14533 ; DB09130 ; DB14487 ; DB14548 ; DB01373
KEGG hsa:6279

Related Compounds  (Total: 2)

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C0934
Name: Aspirin
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C1223
Name: Celecoxib


Related Herbs  (Total: 7)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0004 Huo Xiang藿香 PatchouliPogostemon cablin
H0572 Tu Huo Xiang土藿香 PatchouliPogostemon cablin
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0005 Huo Xiang Ye藿香叶 PatchouliPogostemon cablin
H1010 Du Huo Xiang杜藿香 PatchouliPogostemon cablin
H1120 Guang Huo Xiang广藿香 PatchouliPogostemon cablin