Target Description

Type Detail
Target ID T36TO2
Protein Name Endoglin
Uniprot ID P17813
Protein Name Alias CD antigen CD105
Gene ID 2022
Gene Symbol ENG
Gene Alias END
TTD T22350: Clinical Trial target
Pfam PF00100
GO
0022617:extracellular matrix disassembly

0030509:BMP signaling pathway

0055009:atrial cardiac muscle tissue morphogenesis

0010862:positive regulation of pathway-restricted SMAD protein phosphorylation

0070278:extracellular matrix constituent secretion

0007179:transforming growth factor beta receptor signaling pathway

0042127:regulation of cell population proliferation

0051001:negative regulation of nitric-oxide synthase activity

0004888:transmembrane signaling receptor activity

0022009:central nervous system vasculogenesis

0003148:outflow tract septum morphogenesis

0001837:epithelial to mesenchymal transition

0060348:bone development

0016021:integral component of membrane

0010629:negative regulation of gene expression

0045766:positive regulation of angiogenesis

0050431:transforming growth factor beta binding

0060394:negative regulation of pathway-restricted SMAD protein phosphorylation

0045944:positive regulation of transcription by RNA polymerase II

0042802:identical protein binding

0043235:receptor complex

0030513:positive regulation of BMP signaling pathway

0005534:galactose binding

0051897:positive regulation of protein kinase B signaling

0005615:extracellular space

1905222:atrioventricular canal morphogenesis

1905007:positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation

0001934:positive regulation of protein phosphorylation

0060326:cell chemotaxis

0005114:type II transforming growth factor beta receptor binding

0035912:dorsal aorta morphogenesis

1905065:positive regulation of vascular associated smooth muscle cell differentiation

0042060:wound healing

0007155:cell adhesion

0042325:regulation of phosphorylation

0005024:transforming growth factor beta-activated receptor activity

0006355:regulation of transcription, DNA-templated

0030336:negative regulation of cell migration

0034713:type I transforming growth factor beta receptor binding

0003084:positive regulation of systemic arterial blood pressure

0001666:response to hypoxia

0048745:smooth muscle tissue development

0001937:negative regulation of endothelial cell proliferation

0048844:artery morphogenesis

0003198:epithelial to mesenchymal transition involved in endocardial cushion formation

0031953:negative regulation of protein autophosphorylation

0072563:endothelial microparticle

0042493:response to drug

0031960:response to corticosteroid

0030512:negative regulation of transforming growth factor beta receptor signaling pathway

0009986:cell surface

0000122:negative regulation of transcription by RNA polymerase II

0042803:protein homodimerization activity

0003222:ventricular trabecula myocardium morphogenesis

0005539:glycosaminoglycan binding

0016477:cell migration

0070483:detection of hypoxia

0048870:cell motility

0005925:focal adhesion

0015026:coreceptor activity

0071260:cellular response to mechanical stimulus

0001947:heart looping

0003203:endocardial cushion morphogenesis

0017015:regulation of transforming growth factor beta receptor signaling pathway

0003208:cardiac ventricle morphogenesis

0097084:vascular associated smooth muscle cell development

0005886:plasma membrane

0001570:vasculogenesis

0048845:venous blood vessel morphogenesis

0048185:activin binding

0030155:regulation of cell adhesion

0001569:branching involved in blood vessel morphogenesis

0032967:positive regulation of collagen biosynthetic process

0016604:nuclear body

0003273:cell migration involved in endocardial cushion formation

0001525:angiogenesis

0003209:cardiac atrium morphogenesis

0009897:external side of plasma membrane

PDB 5HZV ; 5HZW ; 5I04
Drugbank DB06322
KEGG hsa:2022

Related Compounds  (Total: 2)

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C0365
Name: Retinal
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C0987
Name: Atorvastatin


Related Herbs  (Total: 5)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0416 Shan Shen山参 NAPanax ginseng
H0357 Ren Shen人参 GinsengPanax ginseng
H0358 Ren Shen Ye人参叶 Ginseng leafPanax ginseng
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0847 Zi He Che紫河车 Human placentaHomo sapiens