HIT-result

Type	Detail
Target ID	T39KTX
Protein Name	General transcription and DNA repair factor IIH helicase subunit XPB
Uniprot ID	P19447
Protein Name Alias	TFIIH subunit XPB; EC 3.6.4.12; Basic transcription factor 2 89 kDa subunit; BTF2 p89; DNA excision repair protein ERCC-3; DNA repair protein complementing XP-B cells; TFIIH basal transcription factor complex 89 kDa subunit; TFIIH 89 kDa subunit; TFIIH p89; Xeroderma pigmentosum group B-complementing protein
Gene ID	2071
Gene Symbol	ERCC3
Gene Alias	XPB; XPBC
TTD	NA
Pfam	PF13625 ; PF16203 ; PF04851
GO	0003677:DNA binding 0008134:transcription factor binding 0005634:nucleus 0006366:transcription by RNA polymerase II 0008104:protein localization 0070911:global genome nucleotide-excision repair 0016887:ATPase activity 0006295:nucleotide-excision repair, DNA incision, 3'-to lesion 0006294:nucleotide-excision repair, preincision complex assembly 1901990:regulation of mitotic cell cycle phase transition 0006361:transcription initiation from RNA polymerase I promoter 0005654:nucleoplasm 0006265:DNA topological change 0006283:transcription-coupled nucleotide-excision repair 0006915:apoptotic process 0000439:transcription factor TFIIH core complex 0006370:7-methylguanosine mRNA capping 0048568:embryonic organ development 0005669:transcription factor TFIID complex 0003684:damaged DNA binding 0009411:response to UV 0005524:ATP binding 0035315:hair cell differentiation 0006289:nucleotide-excision repair 0006281:DNA repair 0000717:nucleotide-excision repair, DNA duplex unwinding 0005675:transcription factor TFIIH holo complex 0033683:nucleotide-excision repair, DNA incision 0000112:nucleotide-excision repair factor 3 complex 0006979:response to oxidative stress 0043065:positive regulation of apoptotic process 0006363:termination of RNA polymerase I transcription 0006368:transcription elongation from RNA polymerase II promoter 0016032:viral process 0008022:protein C-terminus binding 0006367:transcription initiation from RNA polymerase II promoter 0043138:3'-5' DNA helicase activity 0006296:nucleotide-excision repair, DNA incision, 5'-to lesion 0006293:nucleotide-excision repair, preincision complex stabilization 0097550:transcription preinitiation complex 0047485:protein N-terminus binding
PDB	6NMI ; 5IVW ; 6O9M ; 5OF4 ; 5IY9 ; 6RO4 ; 5IY6 ; 6O9L ; 4ERN ; 5IY7 ; 5IY8
Drugbank	NA
KEGG	hsa:2071

Target Description

Related Compounds (Total: 1)

Related Herbs (Total: 1)