HIT-result

Type	Detail
Target ID	T43ZNV
Protein Name	Proteasome subunit beta type-1
Uniprot ID	P20618
Protein Name Alias	Macropain subunit C5; Multicatalytic endopeptidase complex subunit C5; Proteasome component C5; Proteasome gamma chain
Gene ID	5689
Gene Symbol	PSMB1
Gene Alias	PSC5
TTD	NA
Pfam	PF00227
GO	0070062:extracellular exosome 0000165:MAPK cascade 0019774:proteasome core complex, beta-subunit complex 0061418:regulation of transcription from RNA polymerase II promoter in response to hypoxia 0090090:negative regulation of canonical Wnt signaling pathway 0005839:proteasome core complex 0016579:protein deubiquitination 0033209:tumor necrosis factor-mediated signaling pathway 0070498:interleukin-1-mediated signaling pathway 0038095:Fc-epsilon receptor signaling pathway 0002223:stimulatory C-type lectin receptor signaling pathway 0005829:cytosol 0002479:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent 0004298:threonine-type endopeptidase activity 0055085:transmembrane transport 0005576:extracellular region 0031145:anaphase-promoting complex-dependent catabolic process 0043687:post-translational protein modification 0005737:cytoplasm 0000502:proteasome complex 0010499:proteasomal ubiquitin-independent protein catabolic process 0005654:nucleoplasm 1904813:ficolin-1-rich granule lumen 0043161:proteasome-mediated ubiquitin-dependent protein catabolic process 0031146:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process 0043312:neutrophil degranulation 0006521:regulation of cellular amino acid metabolic process 1902036:regulation of hematopoietic stem cell differentiation 0005634:nucleus 0034774:secretory granule lumen 0004175:endopeptidase activity 0010972:negative regulation of G2/M transition of mitotic cell cycle 0038061:NIK/NF-kappaB signaling 0043488:regulation of mRNA stability 0036388:pre-replicative complex assembly 0050852:T cell receptor signaling pathway 0016032:viral process 0060071:Wnt signaling pathway, planar cell polarity pathway 0090263:positive regulation of canonical Wnt signaling pathway 1901990:regulation of mitotic cell cycle phase transition 0000209:protein polyubiquitination
PDB	5L5B ; 5L5O ; 5L62 ; 5VFO ; 5VFR ; 5VFT ; 6AVO ; 6R70 ; 5L5Q ; 5LF7 ; 6WJN ; 6MSK ; 6RGQ ; 4R67 ; 5T0J ; 6MSG ; 6XMJ ; 4R3O ; 5L5H ; 5M32 ; 6REY ; 5VFS ; 6WJD ; 5L5J ; 5L60 ; 5L64 ; 5T0G ; 5LE5 ; 5VFQ ; 6E5B ; 5LF1 ; 6MSD ; 5LF3 ; 6MSB ; 5LF0 ; 5L5T ; 5L4G ; 5L5S ; 5L5V ; 5L5Y ; 6MSH ; 5L5I ; 6KWY ; 5L5F ; 5L5R ; 5L5U ; 5GJQ ; 5L5D ; 6MSE ; 5L5W ; 5L5E ; 5GJR ; 5LEY ; 5LF4 ; 5L5P ; 5L5Z ; 5LEX ; 5T0I ; 5L5X ; 5L63 ; 5M2B ; 5VFU ; 5LF6 ; 5LEZ ; 5T0C ; 5T0H ; 5VFP ; 5A0Q ; 6MSJ ; 5LN3 ; 5L61
Drugbank	DB00188 ; DB08515 ; DB08889
KEGG	hsa:5689

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Name: Celastrol

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0284	Nan She Teng	南蛇藤	Oriental bittersweet	Celastrus orbiculatus
H0016	Ji Xue Cao	积雪草	Asiatic pennywort	Centella asiatica
H0353	Que Mei Teng Gen	雀梅藤根	Hedge sageretia	Sageretia thea
H0130	Lei Gong Teng	雷公藤	Common threewingnut	Tripterygium wilfordii
H1244	Huang Miao	黄苗	NA	Taraxacum mongolicum
H0314	Pu Gong Ying	蒲公英	Mongolian dandelion	Taraxacum mongolicum
H0315	Pu Gong Ying Jin Gao	蒲公英浸膏	Mongolian dandelion	Taraxacum mongolicum