Target Description

Type Detail
Target ID T45I46
Protein Name Mitogen-activated protein kinase kinase kinase 11
Uniprot ID Q16584
Protein Name Alias EC 2.7.11.25;  Mixed lineage kinase 3;  Src-homology 3 domain-containing proline-rich kinase
Gene ID 4296
Gene Symbol MAP3K11
Gene Alias MLK3;  PTK1;  SPRK
TTD T12126: Research target
Pfam PF14604 ; PF07714
GO
0042802:identical protein binding

0046777:protein autophosphorylation

0004672:protein kinase activity

0106310:protein serine kinase activity

0004674:protein serine/threonine kinase activity

0106311:protein threonine kinase activity

0008219:cell death

0031434:mitogen-activated protein kinase kinase binding

0005813:centrosome

0005874:microtubule

0043525:positive regulation of neuron apoptotic process

0044843:cell cycle G1/S phase transition

0043507:positive regulation of JUN kinase activity

0000187:activation of MAPK activity

0005737:cytoplasm

0046330:positive regulation of JNK cascade

0031435:mitogen-activated protein kinase kinase kinase binding

0004706:JUN kinase kinase kinase activity

0005524:ATP binding

0007017:microtubule-based process

0007257:activation of JUN kinase activity

0007254:JNK cascade

0016020:membrane

0043065:positive regulation of apoptotic process

0006468:protein phosphorylation

0042803:protein homodimerization activity

PDB 6AQB ; 5K28 ; 6CQ7 ; 5K26
Drugbank DB12010
KEGG hsa:4296

Related Compounds  (Total: 1)

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C1188
Name: Biochanin


Related Herbs  (Total: 24)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0277 Nan Ban Lan Gen南板蓝根 Indigowoad rootBaphicacanthus cusia
H0246 Mi Ma Huang蜜麻黄 Ephedra equisetinEphedra sinica
H0152 Ling Zhi Jin Gao灵芝浸膏 NAGanoderma lucidum
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0198 Ma Huang Gao麻黄膏 Chinese ephedraEphedra sinica
H1247 Huang Qi黄芪 Membranous milkvetchAstragalus membranaceus
H0197 Ma Huang麻黄 Chinese ephedraEphedra sinica
H1248 Huang Qi Gan Jin Gao黄芪干浸膏 Membranous milkvetchAstragalus membranaceus
H0826 Chu Mu Dan臭牡丹 rose glorybowerClerodendrum bungei
H0957 Dang Gui Teng当归藤 NAEmbelia parviflora
H0555 Tie Xian Cai铁苋菜 Copperleaf herbHerba acalyphae
H0705 Yan Hu Lu Ba盐胡芦巴 FenugreekTrigonella foenum-graecum
H1250 Huang Qi Ti Qu Ye黄芪提取液 Membranous milkvetchAstragalus membranaceus
H0200 Ma Huang Gen麻黄根 Chinese ephedra rootEphedra sinica
H0533 Teng Ku Shen藤苦参 NASophora flavescens
H0153 Ling Zhi(1)灵芝 Lucid ganodermaGanoderma lucidum
H0201 Ma Huang Jin Gao麻黄浸膏 Chinese ephedraEphedra sinica
H1240 Huang Jing Zi黄荆子 NAVitex negundo
H1249 Huang Qi Jin Gao黄芪浸膏 Membranous milkvetchAstragalus membranaceus
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0084 Jiu Li Xiang九里香 Common jasminorangeMurraya paniculata
H0111 Ku Shen苦参 Lightyellow sophoraSophora flavescens
H0575 Tu Ku Shen土苦参 all-grass of hooker wingheadSophora flavescens
H0278 Nan Ban Lan Gen Jin Gao Fen南板蓝根浸膏粉 Indigowoad rootBaphicacanthus cusia