HIT-result

Type	Detail
Target ID	T45I46
Protein Name	Mitogen-activated protein kinase kinase kinase 11
Uniprot ID	Q16584
Protein Name Alias	EC 2.7.11.25; Mixed lineage kinase 3; Src-homology 3 domain-containing proline-rich kinase
Gene ID	4296
Gene Symbol	MAP3K11
Gene Alias	MLK3; PTK1; SPRK
TTD	T12126: Research target
Pfam	PF14604 ; PF07714
GO	0042802:identical protein binding 0046777:protein autophosphorylation 0004672:protein kinase activity 0106310:protein serine kinase activity 0004674:protein serine/threonine kinase activity 0106311:protein threonine kinase activity 0008219:cell death 0031434:mitogen-activated protein kinase kinase binding 0005813:centrosome 0005874:microtubule 0043525:positive regulation of neuron apoptotic process 0044843:cell cycle G1/S phase transition 0043507:positive regulation of JUN kinase activity 0000187:activation of MAPK activity 0005737:cytoplasm 0046330:positive regulation of JNK cascade 0031435:mitogen-activated protein kinase kinase kinase binding 0004706:JUN kinase kinase kinase activity 0005524:ATP binding 0007017:microtubule-based process 0007257:activation of JUN kinase activity 0007254:JNK cascade 0016020:membrane 0043065:positive regulation of apoptotic process 0006468:protein phosphorylation 0042803:protein homodimerization activity
PDB	6AQB ; 5K28 ; 6CQ7 ; 5K26
Drugbank	DB12010
KEGG	hsa:4296

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0198	Ma Huang Gao	麻黄膏	Chinese ephedra	Ephedra sinica
H0201	Ma Huang Jin Gao	麻黄浸膏	Chinese ephedra	Ephedra sinica
H0826	Chu Mu Dan	臭牡丹	rose glorybower	Clerodendrum bungei
H0111	Ku Shen	苦参	Lightyellow sophora	Sophora flavescens
H1240	Huang Jing Zi	黄荆子	NA	Vitex negundo
H1247	Huang Qi	黄芪	Membranous milkvetch	Astragalus membranaceus
H0575	Tu Ku Shen	土苦参	all-grass of hooker winghead	Sophora flavescens
H0246	Mi Ma Huang	蜜麻黄	Ephedra equisetin	Ephedra sinica
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0533	Teng Ku Shen	藤苦参	NA	Sophora flavescens
H0278	Nan Ban Lan Gen Jin Gao Fen	南板蓝根浸膏粉	Indigowoad root	Baphicacanthus cusia
H0152	Ling Zhi Jin Gao	灵芝浸膏	NA	Ganoderma lucidum
H1248	Huang Qi Gan Jin Gao	黄芪干浸膏	Membranous milkvetch	Astragalus membranaceus
H0705	Yan Hu Lu Ba	盐胡芦巴	Fenugreek	Trigonella foenum-graecum
H0153	Ling Zhi(1)	灵芝	Lucid ganoderma	Ganoderma lucidum
H0200	Ma Huang Gen	麻黄根	Chinese ephedra root	Ephedra sinica
H1249	Huang Qi Jin Gao	黄芪浸膏	Membranous milkvetch	Astragalus membranaceus
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0084	Jiu Li Xiang	九里香	Common jasminorange	Murraya paniculata
H0555	Tie Xian Cai	铁苋菜	Copperleaf herb	Herba acalyphae
H0197	Ma Huang	麻黄	Chinese ephedra	Ephedra sinica
H1250	Huang Qi Ti Qu Ye	黄芪提取液	Membranous milkvetch	Astragalus membranaceus
H0277	Nan Ban Lan Gen	南板蓝根	Indigowoad root	Baphicacanthus cusia
H0957	Dang Gui Teng	当归藤	NA	Embelia parviflora

Target Description

Related Compounds (Total: 1)

Related Herbs (Total: 24)