Target Description

Type Detail
Target ID T49USV
Protein Name Nuclear receptor subfamily 0 group B member 2
Uniprot ID Q15466
Protein Name Alias Orphan nuclear receptor SHP;  Small heterodimer partner
Gene ID 8431
Gene Symbol NR0B2
Gene Alias SHP
TTD T89859: Research target
Pfam PF00104
0008203:cholesterol metabolic process


0006367:transcription initiation from RNA polymerase II promoter

0007623:circadian rhythm

0032991:protein-containing complex

0003714:transcription corepressor activity

0045892:negative regulation of transcription, DNA-templated

0042803:protein homodimerization activity

0032922:circadian regulation of gene expression

0010628:positive regulation of gene expression


0010629:negative regulation of gene expression

0045893:positive regulation of transcription, DNA-templated

0043433:negative regulation of DNA-binding transcription factor activity

0046966:thyroid hormone receptor binding

0044877:protein-containing complex binding

0046965:retinoid X receptor binding

0140416:transcription regulator inhibitor activity

0031100:animal organ regeneration

0000122:negative regulation of transcription by RNA polymerase II

0045471:response to ethanol

0008134:transcription factor binding

0042975:peroxisome proliferator activated receptor binding

0009749:response to glucose

0015721:bile acid and bile salt transport

0007219:Notch signaling pathway

0019904:protein domain specific binding

0014070:response to organic cyclic compound

0032024:positive regulation of insulin secretion



PDB 5UFS ; 1YUC ; 6W9M ; 2Z4J ; 2Q3Y ; 4ONI ; 4DOR
Drugbank NA
KEGG hsa:8431

Related Compounds  (Total: 2)

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Name: Bile Acid
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Name: Chenodiol

Related Herbs  (Total: 3)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0431 She Dan Zhi蛇胆汁 Snake bileFel serpentis liquidum
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0847 Zi He Che紫河车 Human placentaHomo sapiens