HIT-result

Type	Detail
Target ID	T51AX1
Protein Name	Interleukin-23 subunit alpha
Uniprot ID	Q9NPF7
Protein Name Alias	IL-23 subunit alpha; IL-23-A; Interleukin-23 subunit p19; IL-23p19
Gene ID	51561
Gene Symbol	IL23A
Gene Alias	SGRF
TTD	T06841: Successful target
Pfam	PF16649
GO	0002230:positive regulation of defense response to virus by host 0034105:positive regulation of tissue remodeling 0002827:positive regulation of T-helper 1 type immune response 0051135:positive regulation of NK T cell activation 0042104:positive regulation of activated T cell proliferation 0032693:negative regulation of interleukin-10 production 0032725:positive regulation of granulocyte macrophage colony-stimulating factor production 1901224:positive regulation of NIK/NF-kappaB signaling 0051607:defense response to virus 0032819:positive regulation of natural killer cell proliferation 0042102:positive regulation of T cell proliferation 0032760:positive regulation of tumor necrosis factor production 0070743:interleukin-23 complex 0051142:positive regulation of NK T cell proliferation 0090023:positive regulation of neutrophil chemotaxis 0032733:positive regulation of interleukin-10 production 0032729:positive regulation of interferon-gamma production 0005576:extracellular region 0042509:regulation of tyrosine phosphorylation of STAT protein 0038155:interleukin-23-mediated signaling pathway 0042098:T cell proliferation 0045087:innate immune response 0045519:interleukin-23 receptor binding 0045672:positive regulation of osteoclast differentiation 0005125:cytokine activity 0042531:positive regulation of tyrosine phosphorylation of STAT protein 0050829:defense response to Gram-negative bacterium 0045944:positive regulation of transcription by RNA polymerase II 0050729:positive regulation of inflammatory response 0043382:positive regulation of memory T cell differentiation 0032816:positive regulation of natural killer cell activation 0005788:endoplasmic reticulum lumen 0019221:cytokine-mediated signaling pathway 0010536:positive regulation of activation of Janus kinase activity 0048771:tissue remodeling 0006954:inflammatory response 0032740:positive regulation of interleukin-17 production 2000318:positive regulation of T-helper 17 type immune response 0032735:positive regulation of interleukin-12 production 0001916:positive regulation of T cell mediated cytotoxicity 2000330:positive regulation of T-helper 17 cell lineage commitment
PDB	5MJ4 ; 4GRW ; 5MJ3 ; 5MZV ; 3QWR ; 3DUH ; 3D85 ; 5NJD ; 3D87 ; 5MXA ; 6UIB
Drugbank	DB14762 ; DB11834 ; DB14004 ; DB05459 ; DB05679
KEGG	hsa:51561

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Name: Triptolide

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0118	Kun Ming Shan Hai Tang	昆明山海棠	Glaucousback threewingnut	Tripterygium hypoglaucum