HIT-result

Target Description

Type	Detail
Target ID	T64QZQ
Protein Name	Erythroid transcription factor
Uniprot ID	P15976
Protein Name Alias	Eryf1; GATA-binding factor 1; GATA-1; GF-1; NF-E1 DNA-binding protein
Gene ID	2623
Gene Symbol	GATA1
Gene Alias	ERYF1; GF1
TTD	NA
Pfam	PF00320
GO	2001240:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand 0032993:protein-DNA complex 0005667:transcription regulator complex 0000976:transcription regulatory region sequence-specific DNA binding 0050731:positive regulation of peptidyl-tyrosine phosphorylation 0035854:eosinophil fate commitment 1990837:sequence-specific double-stranded DNA binding 0043066:negative regulation of apoptotic process 0030220:platelet formation 0097028:dendritic cell differentiation 0070527:platelet aggregation 0007596:blood coagulation 0030219:megakaryocyte differentiation 0033690:positive regulation of osteoblast proliferation 0000977:RNA polymerase II transcription regulatory region sequence-specific DNA binding 0010725:regulation of primitive erythrocyte differentiation 0010559:regulation of glycoprotein biosynthetic process 0017053:transcription repressor complex 0031490:chromatin DNA binding 0007267:cell-cell signaling 0001228:DNA-binding transcription activator activity, RNA polymerase II-specific 0005654:nucleoplasm 0043565:sequence-specific DNA binding 0001701:in utero embryonic development 0045165:cell fate commitment 0070742:C2H2 zinc finger domain binding 0035162:embryonic hemopoiesis 0003677:DNA binding 0002039:p53 binding 2000678:negative regulation of transcription regulatory region DNA binding 0008270:zinc ion binding 0045893:positive regulation of transcription, DNA-templated 0010724:regulation of definitive erythrocyte differentiation 0000785:chromatin 0003700:DNA-binding transcription factor activity 0030218:erythrocyte differentiation 0045944:positive regulation of transcription by RNA polymerase II 1902036:regulation of hematopoietic stem cell differentiation 0030221:basophil differentiation 0005634:nucleus 0071733:transcriptional activation by promoter-enhancer looping 0001085:RNA polymerase II transcription factor binding 0000978:RNA polymerase II cis-regulatory region sequence-specific DNA binding 0030222:eosinophil differentiation 0048821:erythrocyte development 0008584:male gonad development 0030502:negative regulation of bone mineralization 0045648:positive regulation of erythrocyte differentiation 0048873:homeostasis of number of cells within a tissue 0045652:regulation of megakaryocyte differentiation 0000122:negative regulation of transcription by RNA polymerase II 0008285:negative regulation of cell population proliferation 0097067:cellular response to thyroid hormone stimulus 0000981:DNA-binding transcription factor activity, RNA polymerase II-specific 0006357:regulation of transcription by RNA polymerase II
PDB	6G0Q
Drugbank	NA
KEGG	hsa:2623

Type

Detail

Target ID

T64QZQ

Protein Name

Erythroid transcription factor

Uniprot ID

P15976

Protein Name Alias

Eryf1; GATA-binding factor 1; GATA-1; GF-1; NF-E1 DNA-binding protein

Gene ID

2623

Gene Symbol

GATA1

Gene Alias

ERYF1; GF1

TTD

Pfam

PF00320

2001240:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

0032993:protein-DNA complex

0005667:transcription regulator complex

0000976:transcription regulatory region sequence-specific DNA binding

0050731:positive regulation of peptidyl-tyrosine phosphorylation

0035854:eosinophil fate commitment

1990837:sequence-specific double-stranded DNA binding

0043066:negative regulation of apoptotic process

0030220:platelet formation

0097028:dendritic cell differentiation

0070527:platelet aggregation

0007596:blood coagulation

0030219:megakaryocyte differentiation

0033690:positive regulation of osteoblast proliferation

0000977:RNA polymerase II transcription regulatory region sequence-specific DNA binding

0010725:regulation of primitive erythrocyte differentiation

0010559:regulation of glycoprotein biosynthetic process

0017053:transcription repressor complex

0031490:chromatin DNA binding

0007267:cell-cell signaling

0001228:DNA-binding transcription activator activity, RNA polymerase II-specific

0005654:nucleoplasm

0043565:sequence-specific DNA binding

0001701:in utero embryonic development

0045165:cell fate commitment

0070742:C2H2 zinc finger domain binding

0035162:embryonic hemopoiesis

0003677:DNA binding

0002039:p53 binding

2000678:negative regulation of transcription regulatory region DNA binding

0008270:zinc ion binding

0045893:positive regulation of transcription, DNA-templated

0010724:regulation of definitive erythrocyte differentiation

0000785:chromatin

0003700:DNA-binding transcription factor activity

0030218:erythrocyte differentiation

0045944:positive regulation of transcription by RNA polymerase II

1902036:regulation of hematopoietic stem cell differentiation

0030221:basophil differentiation

0005634:nucleus

0071733:transcriptional activation by promoter-enhancer looping

0001085:RNA polymerase II transcription factor binding

0000978:RNA polymerase II cis-regulatory region sequence-specific DNA binding

0030222:eosinophil differentiation

0048821:erythrocyte development

0008584:male gonad development

0030502:negative regulation of bone mineralization

0045648:positive regulation of erythrocyte differentiation

0048873:homeostasis of number of cells within a tissue

0045652:regulation of megakaryocyte differentiation

0000122:negative regulation of transcription by RNA polymerase II

0008285:negative regulation of cell population proliferation

0097067:cellular response to thyroid hormone stimulus

0000981:DNA-binding transcription factor activity, RNA polymerase II-specific

0006357:regulation of transcription by RNA polymerase II

PDB

6G0Q

Drugbank

KEGG

hsa:2623

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Name: 10-Gingerol

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Name: chebulinic acid

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Name: Capsaicin

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0227	Mang Guo Ye	芒果叶	Mango leaf	Mangifera indica
H0446	Sheng Jiang	生姜	Fresh common ginger	Zingiber officinale
H0121	La Jiao Jin Chu Ye	辣椒浸出液	Bush redpepper	Capsicum frutescens
H0122	La Jiao Jin Gao	辣椒浸膏	Bush redpepper	Capsicum frutescens
H0242	Bei Sha Shen Liu Jin Gao	北沙参流浸膏	Glehnia littoralis	Glehnia littoralis
H0119	La Jiao	辣椒	Bush redpepper	Capsicum frutescens
H0239	Bei Sha Shen	北沙参	Coastal glehnia	Glehnia littoralis
H0854	Zi Wei Gen Pi	紫葳根皮	NA	Campsis grandiflora
H0123	La Jiao Liu Jin Gao	辣椒流浸膏	Bush redpepper	Capsicum frutescens

Target Description

Related Compounds (Total: 3)

Related Herbs (Total: 9)