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Compound Description

ID:   C1214 Common name:   Capsaicin
IUPAC:  (E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide CAS:  CAS:404-86-4
Chembl ID:   CHEMBL294199 Pubchem ID:   CID:1548943
Formula:  C18H27NO3 TCM-ID:  TCMC867
Smiles:  CC(C)C=CCCCCC(=O)NCC1=CC(=C(C=C1)O)OC
Alias:

6-Nonenamide, 8-methyl-N-vanillyl-, (E)-;

6-Nonenamide, N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methyl-, (E)-;

Capsaicin;

(6E)-N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamide;

(E)-8-Methyl-N-vanillyl-6-nonenamide;

(E)-N-(4-Hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide;

ALGRX 4975;

Adlea;

Ausanil;

Axsain;

Capsaicine;

Capsicin;

Capsin P 50;

Capzasin-HP;

Chilli Orange;

Dolenon;

E-Capsaicin;

Mioton;

N-(4-Oxy-3-methoxybenzyl)-8-methyl-6-nonenamide;

NGX 4010;

NSC 56353;

Ovocap;

Qutenza;

Ratden PE 40;

Togarashi Orenji;

Zostrix;

trans-8-Methyl-N-vanillyl-6-nonenamide;

trans-Capsaicin
Structure:

Related Targets  (Total: 55)

Target idProtein NameGene SymbolUniprot IDTarget LevelNo.of Literature Evidence
T67KTV Transient receptor potential cation channel subfamily V member 1TRPV1 Q8NER1
 A 3 Reference(s)
T55WN8 Proteinase-activated receptor 2F2RL1 P55085
 A 1 Reference(s)
T09INZ Transient receptor potential cation channel subfamily A member 1TRPA1 O75762
 A 1 Reference(s)
T89K3V Ecto-NOX disulfide-thiol exchanger 2ENOX2 Q16206
 A 1 Reference(s)
T02QBS Cytochrome P450 1A2CYP1A2 P05177
 A 1 Reference(s)
T30D9G Superoxide dismutase [Cu-Zn]SOD1 P00441
 A 1 Reference(s)
T46K2X Heat shock 70 kDa protein 4HSPA4 P34932
 A 1 Reference(s)
T15P3B Transient receptor potential cation channel subfamily V member 2TRPV2 Q9Y5S1
 A 1 Reference(s)
T16A2X CatalaseCAT P04040
 A 1 Reference(s)
T12PIB Lysosomal alpha-glucosidaseGAA P10253
 A 1 Reference(s)
T52S7S Neuromedin-K receptorTACR3 P29371
 A 1 Reference(s)
T41ZO1 Chymotrypsin-CCTRC Q99895
 B 1 Reference(s)
T44LWL Transcription factor p65RELA Q04206
 B 1 Reference(s)
T46YMA Ras-related C3 botulinum toxin substrate 1RAC1 P63000
 B 1 Reference(s)
T76TED Pro-opiomelanocortinPOMC P01189
 B 1 Reference(s)
T08Q7W Prostaglandin G/H synthase 2PTGS2 P35354
 B 1 Reference(s)
T86ROZ Heme oxygenase 1HMOX1 P09601
 B 2 Reference(s)
T88TDZ RAC-alpha serine/threonine-protein kinaseAKT1 P31749
 B 1 Reference(s)
T22OPB Nuclear factor erythroid 2-related factor 2NFE2L2 Q16236
 B 2 Reference(s)
T80OJF Interstitial collagenaseMMP1 P03956
 B 1 Reference(s)
T56TXY Polyunsaturated fatty acid 5-lipoxygenaseALOX5 P09917
 B 1 Reference(s)
T88BCB Glycerol-3-phosphate phosphatasePGP A6NDG6
 B 1 Reference(s)
T20JZ2 Androgen receptorAR P10275
 B 1 Reference(s)
T79KQO NF-kappa-B inhibitor alphaNFKBIA P25963
 B 1 Reference(s)
T71K92 Apoptosis regulator Bcl-2BCL2 P10415
 B 2 Reference(s)
T85U8U Caspase-3CASP3 P42574
 B 1 Reference(s)
T63GUB Proto-oncogene c-FosFOS P01100
 B 4 Reference(s)
T68BGR Glial fibrillary acidic proteinGFAP P14136
 B 1 Reference(s)
T40JMU Glutamine synthetaseGLUL P15104
 B 1 Reference(s)
T42EAZ Vascular endothelial growth factor AVEGFA P15692
 B 1 Reference(s)
T75B9S Cyclic AMP-responsive element-binding protein 1CREB1 P16220
 B 1 Reference(s)
T29WP4 Protransforming growth factor alpha [Cleaved into: Transforming growth factor alphaTGFA P01135
 B 1 Reference(s)
T77FOL NeuromodulinGAP43 P17677
 B 1 Reference(s)
T97KFC Transcription factor jun-BJUNB P17275
 B 1 Reference(s)
T81I4T 5'-AMP-activated protein kinase catalytic subunit alpha-1PRKAA1 Q13131
 B 2 Reference(s)
T29C64 Calcitonin gene-related peptide 1CALCA P06881;P01258
 B 3 Reference(s)
T79WXA Mitogen-activated protein kinase 1MAPK1 P28482
 C 1 Reference(s)
T40KDU Hemoglobin subunit betaHBB P68871
 C 1 Reference(s)
T04AHN 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2HSD3B2 P26439
 C 1 Reference(s)
T08U92 Mitochondrial brown fat uncoupling protein 1UCP1 P25874
 C 1 Reference(s)
T89LO8 Erythropoietin receptorEPOR P19235
 C 1 Reference(s)
T43BTC Glycophorin-AGYPA P02724
 C 1 Reference(s)
T64QZQ Erythroid transcription factorGATA1 P15976
 C 1 Reference(s)
T22XVR Transcription factor PU.1SPI1 P17947
 C 1 Reference(s)
T27BN7 Protachykinin-1TAC1 P20366
 C 1 Reference(s)
T50WOV ATP-dependent translocase ABCB1ABCB1 P08183
 C 1 Reference(s)
T61HH0 Prostate-specific antigenKLK3 P07288
 C 1 Reference(s)
T88A0X Substance-P receptorTACR1 P25103
 C 1 Reference(s)
T36U0M Neuropilin-1NRP1 O14786
 C 1 Reference(s)
T93SFQ NAD-dependent protein deacetylase sirtuin-1SIRT1 Q96EB6
 C 2 Reference(s)
T93YV8 Tumor necrosis factor receptor superfamily member 11BTNFRSF11B O00300
 C 1 Reference(s)
T24UPH NAMIR206 NA
 C 1 Reference(s)
T85AXP Cytochrome P450 3A4CYP3A4 P08684
 C 1 Reference(s)
T35QZO Cytochrome cCYCS P99999
 C 1 Reference(s)
T70VMI Nitric oxide synthase, brainNOS1 P29475
 C 1 Reference(s)

*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".

Related Herbs  (Total: 8)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0854 Zi Wei Gen Pi紫葳根皮 NACampsis grandiflora
H0123 La Jiao Liu Jin Gao辣椒流浸膏 Bush redpepperCapsicum frutescens
H0242 Bei Sha Shen Liu Jin Gao北沙参流浸膏 Glehnia littoralisGlehnia littoralis
H0119 La Jiao辣椒 Bush redpepperCapsicum frutescens
H0227 Mang Guo Ye芒果叶 Mango leafMangifera indica
H0121 La Jiao Jin Chu Ye辣椒浸出液 Bush redpepperCapsicum frutescens
H0239 Bei Sha Shen北沙参 Coastal glehniaGlehnia littoralis
H0122 La Jiao Jin Gao辣椒浸膏 Bush redpepperCapsicum frutescens

Ckey description of the interaction between compound and target


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