HIT-result

Type	Detail
Target ID	T66FP0
Protein Name	cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Uniprot ID	Q08499
Protein Name Alias	EC 3.1.4.53; DPDE3; PDE43
Gene ID	5144
Gene Symbol	PDE4D
Gene Alias	DPDE3
TTD	T02001: Successful target
Pfam	PF18100 ; PF00233
GO	0045822:negative regulation of heart contraction 0005634:nucleus 0046872:metal ion binding 0034704:calcium channel complex 0061028:establishment of endothelial barrier 0005829:cytosol 0005891:voltage-gated calcium channel complex 0097110:scaffold protein binding 0006198:cAMP catabolic process 0032754:positive regulation of interleukin-5 production 0050852:T cell receptor signaling pathway 0016020:membrane 0004115:3',5'-cyclic-AMP phosphodiesterase activity 0030552:cAMP binding 0031698:beta-2 adrenergic receptor binding 0019899:enzyme binding 0032743:positive regulation of interleukin-2 production 0004114:3',5'-cyclic-nucleotide phosphodiesterase activity 0044325:ion channel binding 0007165:signal transduction 0032729:positive regulation of interferon-gamma production 1901844:regulation of cell communication by electrical coupling involved in cardiac conduction 0043951:negative regulation of cAMP-mediated signaling 0010880:regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 0071872:cellular response to epinephrine stimulus 0005815:microtubule organizing center 0071875:adrenergic receptor signaling pathway 0086004:regulation of cardiac muscle cell contraction 0051117:ATPase binding 1901898:negative regulation of relaxation of cardiac muscle 0060314:regulation of ryanodine-sensitive calcium-release channel activity 0086024:adenylate cyclase-activating adrenergic receptor signaling pathway involved in positive regulation of heart rate 0019933:cAMP-mediated signaling 0005886:plasma membrane 0016324:apical plasma membrane 0010469:regulation of signaling receptor activity 0007186:G protein-coupled receptor signaling pathway 1901363:heterocyclic compound binding 0002027:regulation of heart rate 0071320:cellular response to cAMP 0048471:perinuclear region of cytoplasm 0033137:negative regulation of peptidyl-serine phosphorylation
PDB	6F6U ; 6FW3 ; 1MKD ; 2FM0 ; 2FM5 ; 6IMI ; 1Y2E ; 3G4L ; 5WQA ; 5LBO ; 1PTW ; 3SL4 ; 6IND ; 6KJZ ; 1TBB ; 6FEB ; 1Y2K ; 6IMO ; 6ZBA ; 6NJJ ; 4OGB ; 1TB7 ; 6IBF ; 1OYN ; 6RCW ; 3G4K ; 4WCU ; 6HWO ; 6INM ; 2PW3 ; 3G4I ; 6FDC ; 3V9B ; 6NJH ; 1Y2D ; 5WH5 ; 6F8X ; 6F8T ; 6F8R ; 6F8W ; 5K32 ; 1E9K ; 3SL5 ; 1XOQ ; 6F8V ; 6FTA ; 1Y2B ; 6IM6 ; 5TKB ; 3IAD ; 4W1O ; 6IMT ; 6FDI ; 1Y2C ; 3SL6 ; 6FTW ; 1XOR ; 6IMR ; 6AKR ; 5WH6 ; 6IAG ; 6BOJ ; 3IAK ; 2QYN ; 5K1I ; 6IMB ; 3K4S ; 6NJI ; 3G4G ; 1Q9M ; 6IMD ; 3SL3 ; 3G58 ; 1XON ; 6KK0 ; 6INK ; 1ZKN ; 6FET ; 6FE7 ; 3SL8 ; 6F8U ; 1XOM ; 6FT0
Drugbank	DB03183 ; DB05266 ; DB01656 ; DB04149 ; DB07051 ; DB02676 ; DB06842 ; DB04271 ; DB01427 ; DB01954 ; DB01088 ; DB01791 ; DB09283 ; DB07954 ; DB00131 ; DB04469 ; DB08299 ; DB02918 ; DB01959 ; DB00201 ; DB06246 ; DB03606 ; DB00651 ; DB05298 ; DB05219 ; DB03849
KEGG	hsa:5144

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Name: Diazepam

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Name: Oxyresveratrol

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Name: Shogaol

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Name: phosphatidic acid

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0269	Mu Gua	木瓜	Chinese floweringquince	Chaenomeles sinensis
H0743	Yi Zhi Ren	益智仁	Sharpleaf galangal	Alpinia oxyphylla
H0740	Yi Zhi	益智	Fructus alpinae oxyphyllae	Alpinia oxyphylla
H0396	Sang Ye	桑叶	White mulberry leaf	Morus alba
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0446	Sheng Jiang	生姜	Fresh common ginger	Zingiber officinale
H0932	Ba Qia	菝葜	Chinaroot greenbrier	Smilax china
H0391	Sang Pi	桑皮	Prepared root-bark white mulberry	Morus alba
H0397	Sang Zhi	桑枝	White mulberry branch	Morus alba
H0570	Tu Fu Ling	土茯苓	Glabrous greenbrier	Smilax glabra
H0030	Jiang Pi	姜皮	Ginger peel	Cortex zingiberis