HIT-result

Target Description

Type	Detail
Target ID	T71BV3
Protein Name	Glutathione peroxidase 1
Uniprot ID	P07203
Protein Name Alias	GPx-1; GSHPx-1; EC 1.11.1.9; Cellular glutathione peroxidase
Gene ID	2876
Gene Symbol	GPX1
Gene Alias	NA
TTD	T70654: Research target
Pfam	PF00255
GO	0033599:regulation of mammary gland epithelial cell proliferation 0045454:cell redox homeostasis 0042542:response to hydrogen peroxide 0048741:skeletal muscle fiber development 0004602:glutathione peroxidase activity 0005829:cytosol 0006641:triglyceride metabolic process 0018158:protein oxidation 0010269:response to selenium ion 0001885:endothelial cell development 0034599:cellular response to oxidative stress 0043403:skeletal muscle tissue regeneration 0019369:arachidonic acid metabolic process 0051897:positive regulation of protein kinase B signaling 0009650:UV protection 0045444:fat cell differentiation 0090201:negative regulation of release of cytochrome c from mitochondria 0010332:response to gamma radiation 0005759:mitochondrial matrix 0042311:vasodilation 0009609:response to symbiotic bacterium 0001659:temperature homeostasis 0002862:negative regulation of inflammatory response to antigenic stimulus 1902042:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors 0007605:sensory perception of sound 0017124:SH3 domain binding 1902905:positive regulation of supramolecular fiber organization 0019372:lipoxygenase pathway 0051450:myoblast proliferation 0043154:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process 0033194:response to hydroperoxide 0004601:peroxidase activity 0060055:angiogenesis involved in wound healing 0047066:phospholipid-hydroperoxide glutathione peroxidase activity 0006195:purine nucleotide catabolic process 0005739:mitochondrion 0005737:cytoplasm 0040029:regulation of gene expression, epigenetic 1902176:negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway 0061136:regulation of proteasomal protein catabolic process 0043534:blood vessel endothelial cell migration 0042744:hydrogen peroxide catabolic process 0051702:biological process involved in interaction with symbiont 0060047:heart contraction 0006749:glutathione metabolic process 0009410:response to xenobiotic stimulus
PDB	2F8A
Drugbank	DB09061 ; DB14011 ; DB14009 ; DB00143 ; DB11091 ; DB11127 ; DB09221 ; DB03310 ; DB11590
KEGG	hsa:2876

Type

Detail

Target ID

T71BV3

Protein Name

Glutathione peroxidase 1

Uniprot ID

P07203

Protein Name Alias

GPx-1; GSHPx-1; EC 1.11.1.9; Cellular glutathione peroxidase

Gene ID

2876

Gene Symbol

GPX1

Gene Alias

TTD

T70654: Research target

Pfam

PF00255

0033599:regulation of mammary gland epithelial cell proliferation

0045454:cell redox homeostasis

0042542:response to hydrogen peroxide

0048741:skeletal muscle fiber development

0004602:glutathione peroxidase activity

0005829:cytosol

0006641:triglyceride metabolic process

0018158:protein oxidation

0010269:response to selenium ion

0001885:endothelial cell development

0034599:cellular response to oxidative stress

0043403:skeletal muscle tissue regeneration

0019369:arachidonic acid metabolic process

0051897:positive regulation of protein kinase B signaling

0009650:UV protection

0045444:fat cell differentiation

0090201:negative regulation of release of cytochrome c from mitochondria

0010332:response to gamma radiation

0005759:mitochondrial matrix

0042311:vasodilation

0009609:response to symbiotic bacterium

0001659:temperature homeostasis

0002862:negative regulation of inflammatory response to antigenic stimulus

1902042:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

0007605:sensory perception of sound

0017124:SH3 domain binding

1902905:positive regulation of supramolecular fiber organization

0019372:lipoxygenase pathway

0051450:myoblast proliferation

0043154:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

0033194:response to hydroperoxide

0004601:peroxidase activity

0060055:angiogenesis involved in wound healing

0047066:phospholipid-hydroperoxide glutathione peroxidase activity

0006195:purine nucleotide catabolic process

0005739:mitochondrion

0005737:cytoplasm

0040029:regulation of gene expression, epigenetic

1902176:negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

0061136:regulation of proteasomal protein catabolic process

0043534:blood vessel endothelial cell migration

0042744:hydrogen peroxide catabolic process

0051702:biological process involved in interaction with symbiont

0060047:heart contraction

0006749:glutathione metabolic process

0009410:response to xenobiotic stimulus

PDB

2F8A

Drugbank

DB09061 ; DB14011 ; DB14009 ; DB00143 ; DB11091 ; DB11127 ; DB09221 ; DB03310 ; DB11590

KEGG

hsa:2876

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H1163	He Bao Cao	荷包草	NA	Lamprocapnos spectabilis
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0736	Yi Dian Hong	一点红	Sowthistle tasselflower	Emilia sonchifolia
H0943	Dan Cai	淡菜	Mussel	Mytilus edulis
H0849	Zi Su Geng	紫苏梗	Common perilla stem	Perilla frutescens var. arguta
H0006	Bai Qu Cai	白屈菜	Greater celandine	Chelidonium majus
H0095	Gou Qi Zi	枸杞子	Chinese wolfberry fruit	Lycium chinense
H0094	Gou Qi	枸杞	Chinese wolfberry fruit	Lycium chinense
H0850	Zi Su Ye	紫苏叶	Common perilla leaf	Perilla frutescens var. arguta
H0352	Quan Xie	全蝎	Scorpion	Buthus martensi
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens

Target Description

Related Compounds (Total: 3)

Related Herbs (Total: 11)