Target Description

Type Detail
Target ID T76F14
Protein Name DNA mismatch repair protein Msh2
Uniprot ID P43246
Protein Name Alias hMSH2;  MutS protein homolog 2
Gene ID 4436
Gene Symbol MSH2
Gene Alias NA
TTD T46849: Research target
Pfam PF05190 ; PF05188 ; PF00488 ; PF05192 ; PF01624
GO
0032137:guanine/thymine mispair binding

0031573:intra-S DNA damage checkpoint

0048304:positive regulation of isotype switching to IgG isotypes

0003684:damaged DNA binding

0019724:B cell mediated immunity

0002204:somatic recombination of immunoglobulin genes involved in immune response

0005524:ATP binding

0016446:somatic hypermutation of immunoglobulin genes

0051096:positive regulation of helicase activity

0016020:membrane

0008022:protein C-terminus binding

0003682:chromatin binding

0006119:oxidative phosphorylation

0000781:chromosome, telomeric region

0006298:mismatch repair

0007050:cell cycle arrest

0008094:DNA-dependent ATPase activity

0045910:negative regulation of DNA recombination

0007281:germ cell development

0019237:centromeric DNA binding

0008340:determination of adult lifespan

0005654:nucleoplasm

0001701:in utero embryonic development

0019899:enzyme binding

0006301:postreplication repair

0071168:protein localization to chromatin

0003677:DNA binding

0043570:maintenance of DNA repeat elements

0048298:positive regulation of isotype switching to IgA isotypes

0042803:protein homodimerization activity

0006302:double-strand break repair

0005634:nucleus

0019901:protein kinase binding

0032301:MutSalpha complex

0006281:DNA repair

0000406:double-strand/single-strand DNA junction binding

0008584:male gonad development

0043524:negative regulation of neuron apoptotic process

0030183:B cell differentiation

0032302:MutSbeta complex

0045190:isotype switching

0010165:response to X-ray

0016447:somatic recombination of immunoglobulin gene segments

0042771:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

0032300:mismatch repair complex

0006310:DNA recombination

0010224:response to UV-B

PDB 2O8B ; 2O8F ; 2O8C ; 3THZ ; 3THX ; 2O8E ; 3THW ; 3THY ; 2O8D
Drugbank NA
KEGG hsa:4436

Related Compounds  (Total: 1)

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C1227
Name: Chelerythrine


Related Herbs  (Total: 4)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0006 Bai Qu Cai白屈菜 Greater celandineChelidonium majus
H1163 He Bao Cao荷包草 NALamprocapnos spectabilis
H1214 Hua Jiao花椒 Bunge pricklyashZanthoxylum bungeanum
H0233 Mao Liang Mian Zhen毛两面针 NAZanthoxylum nitidum