HIT-result

Type	Detail
Target ID	T78GRC
Protein Name	Aldo-keto reductase family 1 member C3
Uniprot ID	P42330
Protein Name Alias	EC 1.1.1.-; EC 1.1.1.210; EC 1.1.1.53; EC 1.1.1.62; 17-beta-hydroxysteroid dehydrogenase type 5; 17-beta-HSD 5; 3-alpha-HSD type II, brain; 3-alpha-hydroxysteroid dehydrogenase type 2; 3-alpha-HSD type 2; EC 1.1.1.357; Chlordecone reductase homolog HAKRb; Dihydrodiol dehydrogenase 3; DD-3; DD3; Dihydrodiol dehydrogenase type I; HA1753; Prostaglandin F synthase; PGFS; EC 1.1.1.188; Testosterone 17-beta-dehydrogenase 5; EC 1.1.1.239; EC 1.1.1.64
Gene ID	8644
Gene Symbol	AKR1C3
Gene Alias	DDH1; HSD17B5; KIAA0119; PGFS
TTD	T60857: Successful target
Pfam	PF00248
GO	0042572:retinol metabolic process 0047024:5alpha-androstane-3beta,17beta-diol dehydrogenase activity 0035410:dihydrotestosterone 17-beta-dehydrogenase activity 2000224:regulation of testosterone biosynthetic process 0044597:daunorubicin metabolic process 0042574:retinal metabolic process 0009267:cellular response to starvation 0061370:testosterone biosynthetic process 0008284:positive regulation of cell population proliferation 0030216:keratinocyte differentiation 0047017:prostaglandin-F synthase activity 0047787:delta4-3-oxosteroid 5beta-reductase activity 0004033:aldo-keto reductase (NADP) activity 0071395:cellular response to jasmonic acid stimulus 0043170:macromolecule metabolic process 0047035:testosterone dehydrogenase (NAD+) activity 0019371:cyclooxygenase pathway 0048385:regulation of retinoic acid receptor signaling pathway 0001758:retinal dehydrogenase activity 0005829:cytosol 0070062:extracellular exosome 2000379:positive regulation of reactive oxygen species metabolic process 0051897:positive regulation of protein kinase B signaling 0006693:prostaglandin metabolic process 0036130:prostaglandin H2 endoperoxidase reductase activity 0071379:cellular response to prostaglandin stimulus 0016488:farnesol catabolic process 0001523:retinoid metabolic process 0016229:steroid dehydrogenase activity 0008584:male gonad development 0005634:nucleus 0044594:17-beta-hydroxysteroid dehydrogenase (NAD+) activity 0047086:ketosteroid monooxygenase activity 0047834:D-threo-aldose 1-dehydrogenase activity 0036131:prostaglandin D2 11-ketoreductase activity 0007584:response to nutrient 0044598:doxorubicin metabolic process 0032052:bile acid binding 1900053:negative regulation of retinoic acid biosynthetic process 0034614:cellular response to reactive oxygen species 2000353:positive regulation of endothelial cell apoptotic process 0047023:androsterone dehydrogenase activity 0047044:androstan-3-alpha,17-beta-diol dehydrogenase activity 0071384:cellular response to corticosteroid stimulus 0047045:testosterone 17-beta-dehydrogenase (NADP+) activity 0072582:17-beta-hydroxysteroid dehydrogenase (NADP+) activity 0018636:phenanthrene 9,10-monooxygenase activity 0005737:cytoplasm 0010942:positive regulation of cell death 0042448:progesterone metabolic process 0047020:15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity 0004032:alditol:NADP+ 1-oxidoreductase activity 0071799:cellular response to prostaglandin D stimulus 0004745:retinol dehydrogenase activity 0070293:renal absorption 0045550:geranylgeranyl reductase activity 0007186:G protein-coupled receptor signaling pathway 0071277:cellular response to calcium ion 0016655:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 0071276:cellular response to cadmium ion 0008202:steroid metabolic process 0045703:ketoreductase activity
PDB	1XF0 ; 1S1R ; 1RY0 ; 2F38 ; 3R8H ; 4FAM ; 4HMN ; 4WDW ; 3UG8 ; 4DZ5 ; 6GXK ; 3UGR ; 1ZQ5 ; 4WDU ; 4H7C ; 3R8G ; 4DBW ; 4FA3 ; 3UFY ; 1S2A ; 4YVV ; 6F78 ; 4DBS ; 3R43 ; 7C7F ; 3R94 ; 4DBU ; 7C7H ; 4XVD ; 4FAL ; 7C7G ; 1S2C ; 1S1P ; 3UWE ; 5HNU ; 1RY8 ; 6F2U ; 4YVX ; 4ZFC ; 4WDX ; 4WDT ; 3R6I ; 3R58 ; 6A7B ; 3R7M ; 4XVE ; 2FGB ; 5HNT ; 4WRH
Drugbank	DB00959 ; DB01039 ; DB00157 ; DB00328 ; DB06077 ; DB03461 ; DB07700 ; DB02056 ; DB01698 ; DB00997 ; DB13751 ; DB02266 ; DB01536 ; DB00776
KEGG	hsa:8644

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Name: Lithocholic Acid

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Name: Baccharin

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0293	Niu Jiao Tan	牛角炭	Buffalo horn	Bubalus bubalis
H0291	Niu Jiao Fen	牛角粉	Buffalo horn	Bubalus bubalis
H1183	Hong Dou	红豆	Hosie ormosia	Ormosia hosiei
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0489	Shui Niu Jiao Nong Suo Fen	水牛角浓缩粉	Buffalo horn	Bubalus bubalis
H0487	Shui Niu Jiao	水牛角	Buffalo horn	Bubalus bubalis
H0488	Shui Niu Jiao Gan Jin Gao	水牛角干浸膏	Buffalo horn	Bubalus bubalis
H0292	Niu Jiao Jian Fen	牛角尖粉	Buffalo horn	Bubalus bubalis