HIT-result

Target Description

Type	Detail
Target ID	T82GHD
Protein Name	Kit ligand
Uniprot ID	P21583
Protein Name Alias	Mast cell growth factor; MGF; Stem cell factor; SCF; c-Kit ligand
Gene ID	4254
Gene Symbol	KITLG
Gene Alias	MGF; SCF
TTD	T90089: Research target
Pfam	PF02404
GO	0002763:positive regulation of myeloid leukocyte differentiation 0007155:cell adhesion 0045636:positive regulation of melanocyte differentiation 0097192:extrinsic apoptotic signaling pathway in absence of ligand 0033026:negative regulation of mast cell apoptotic process 1901534:positive regulation of hematopoietic progenitor cell differentiation 0070668:positive regulation of mast cell proliferation 0008284:positive regulation of cell population proliferation 0051897:positive regulation of protein kinase B signaling 0030175:filopodium 0005615:extracellular space 0035234:ectopic germ cell programmed cell death 0000165:MAPK cascade 0005173:stem cell factor receptor binding 0046579:positive regulation of Ras protein signal transduction 0008083:growth factor activity 0005886:plasma membrane 0005125:cytokine activity 0050731:positive regulation of peptidyl-tyrosine phosphorylation 0002687:positive regulation of leukocyte migration 0016021:integral component of membrane 1902035:positive regulation of hematopoietic stem cell proliferation 0005856:cytoskeleton 0035162:embryonic hemopoiesis 0008584:male gonad development 0001755:neural crest cell migration 0005576:extracellular region 0001541:ovarian follicle development 0043406:positive regulation of MAP kinase activity 0005737:cytoplasm 0030027:lamellipodium
PDB	2E9W ; 1EXZ ; 1SCF
Drugbank	NA
KEGG	hsa:4254

Type

Detail

Target ID

T82GHD

Protein Name

Kit ligand

Uniprot ID

P21583

Protein Name Alias

Mast cell growth factor; MGF; Stem cell factor; SCF; c-Kit ligand

Gene ID

4254

Gene Symbol

KITLG

Gene Alias

MGF; SCF

TTD

T90089: Research target

Pfam

PF02404

0002763:positive regulation of myeloid leukocyte differentiation

0007155:cell adhesion

0045636:positive regulation of melanocyte differentiation

0097192:extrinsic apoptotic signaling pathway in absence of ligand

0033026:negative regulation of mast cell apoptotic process

1901534:positive regulation of hematopoietic progenitor cell differentiation

0070668:positive regulation of mast cell proliferation

0008284:positive regulation of cell population proliferation

0051897:positive regulation of protein kinase B signaling

0030175:filopodium

0005615:extracellular space

0035234:ectopic germ cell programmed cell death

0000165:MAPK cascade

0005173:stem cell factor receptor binding

0046579:positive regulation of Ras protein signal transduction

0008083:growth factor activity

0005886:plasma membrane

0005125:cytokine activity

0050731:positive regulation of peptidyl-tyrosine phosphorylation

0002687:positive regulation of leukocyte migration

0016021:integral component of membrane

1902035:positive regulation of hematopoietic stem cell proliferation

0005856:cytoskeleton

0035162:embryonic hemopoiesis

0008584:male gonad development

0001755:neural crest cell migration

0005576:extracellular region

0001541:ovarian follicle development

0043406:positive regulation of MAP kinase activity

0005737:cytoplasm

0030027:lamellipodium

PDB

2E9W ; 1EXZ ; 1SCF

Drugbank

KEGG

hsa:4254

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0224	Man Tuo Luo Ye	曼陀罗叶	Hindu datura leaf	Datura metel
H0225	Man Tuo Luo Zi	曼陀罗子	Hindu datura seed	Datura metel
H0365	Rou Dou Kou	肉豆蔻	Common nutmeg	Myristica fragrans
H0746	Yin Chen Hao Gan Jin Gao	茵陈蒿干浸膏	Capillary wormwood	Artemisia capillaris
H0216	Man Jing Ye	蔓荆叶	Threeleaf chastetree leaf	Vitex trifolia
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0720	Yang Jin Hua	洋金花	Hindu datura flower	Datura metel
H0085	Jiu Yu Rou	酒萸肉	Asiatic cornelian cherry	Cornus officinalis
H0331	Qiang Huo	羌活	Incised notopterygium	Notopterygium incisum
H0881	Chuan Qiang Huo	川羌活	Incised notopterygium	Notopterygium incisum
H0418	Shan Yin Chen	山茵陈	Capillary wormwood	Artemisia capillaris
H1183	Hong Dou	红豆	Hosie ormosia	Ormosia hosiei
H0745	Yin Chen Hao	茵陈蒿	Capillary wormwood	Artemisia capillaris
H0427	Shan Zhu Yu	山茱萸	Asiatic cornelian cherry	Cornus officinalis
H0217	Man Jing Zi	蔓荆子	Threeleaf chastetree fruit	Vitex trifolia
H0585	Tu Yin Chen Hao	土茵陈蒿	Capillary wormwood	Artemisia capillaris
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens

Target Description

Related Compounds (Total: 2)

Related Herbs (Total: 17)