HIT-result

Type	Detail
Target ID	T88EIE
Protein Name	Platelet-derived growth factor subunit A
Uniprot ID	P04085
Protein Name Alias	PDGF subunit A; PDGF-1; Platelet-derived growth factor A chain; Platelet-derived growth factor alpha polypeptide
Gene ID	5154
Gene Symbol	PDGFA
Gene Alias	PDGF1
TTD	T06869: Clinical Trial target
Pfam	PF00341 ; PF04692
GO	0048407:platelet-derived growth factor binding 0070851:growth factor receptor binding 0005902:microvillus 0001775:cell activation 0043410:positive regulation of MAPK cascade 0005796:Golgi lumen 0000165:MAPK cascade 0005615:extracellular space 0060683:regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling 0043588:skin development 0014910:regulation of smooth muscle cell migration 0048146:positive regulation of fibroblast proliferation 0032956:regulation of actin cytoskeleton organization 1990401:embryonic lung development 0009986:cell surface 0030031:cell projection assembly 0001525:angiogenesis 0030036:actin cytoskeleton organization 0002576:platelet degranulation 0005161:platelet-derived growth factor receptor binding 0009611:response to wounding 0042802:identical protein binding 0046982:protein heterodimerization activity 0005576:extracellular region 0001942:hair follicle development 0008083:growth factor activity 0007267:cell-cell signaling 0048008:platelet-derived growth factor receptor signaling pathway 0010544:negative regulation of platelet activation 0031093:platelet alpha granule lumen 0030335:positive regulation of cell migration 0005518:collagen binding 0042803:protein homodimerization activity 0031954:positive regulation of protein autophosphorylation 0008284:positive regulation of cell population proliferation 0070374:positive regulation of ERK1 and ERK2 cascade 0009887:animal organ morphogenesis 0042060:wound healing 0030198:extracellular matrix organization 0005788:endoplasmic reticulum lumen 0010512:negative regulation of phosphatidylinositol biosynthetic process 0014068:positive regulation of phosphatidylinositol 3-kinase signaling 0000139:Golgi membrane 0048286:lung alveolus development 0051781:positive regulation of cell division 0050730:regulation of peptidyl-tyrosine phosphorylation 0051897:positive regulation of protein kinase B signaling 0043406:positive regulation of MAP kinase activity 0050919:negative chemotaxis 0002053:positive regulation of mesenchymal cell proliferation 0035793:positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
PDB	3MJK
Drugbank	NA
KEGG	hsa:5154

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