Target Description

Type Detail
Target ID T88EIE
Protein Name Platelet-derived growth factor subunit A
Uniprot ID P04085
Protein Name Alias PDGF subunit A;  PDGF-1;  Platelet-derived growth factor A chain;  Platelet-derived growth factor alpha polypeptide
Gene ID 5154
Gene Symbol PDGFA
Gene Alias PDGF1
TTD T06869: Clinical Trial target
Pfam PF00341 ; PF04692
0048407:platelet-derived growth factor binding

0070851:growth factor receptor binding


0001775:cell activation

0043410:positive regulation of MAPK cascade

0005796:Golgi lumen

0000165:MAPK cascade

0005615:extracellular space

0060683:regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling

0043588:skin development

0014910:regulation of smooth muscle cell migration

0048146:positive regulation of fibroblast proliferation

0032956:regulation of actin cytoskeleton organization

1990401:embryonic lung development

0009986:cell surface

0030031:cell projection assembly


0030036:actin cytoskeleton organization

0002576:platelet degranulation

0005161:platelet-derived growth factor receptor binding

0009611:response to wounding

0042802:identical protein binding

0046982:protein heterodimerization activity

0005576:extracellular region

0001942:hair follicle development

0008083:growth factor activity

0007267:cell-cell signaling

0048008:platelet-derived growth factor receptor signaling pathway

0010544:negative regulation of platelet activation

0031093:platelet alpha granule lumen

0030335:positive regulation of cell migration

0005518:collagen binding

0042803:protein homodimerization activity

0031954:positive regulation of protein autophosphorylation

0008284:positive regulation of cell population proliferation

0070374:positive regulation of ERK1 and ERK2 cascade

0009887:animal organ morphogenesis

0042060:wound healing

0030198:extracellular matrix organization

0005788:endoplasmic reticulum lumen

0010512:negative regulation of phosphatidylinositol biosynthetic process

0014068:positive regulation of phosphatidylinositol 3-kinase signaling

0000139:Golgi membrane

0048286:lung alveolus development

0051781:positive regulation of cell division

0050730:regulation of peptidyl-tyrosine phosphorylation

0051897:positive regulation of protein kinase B signaling

0043406:positive regulation of MAP kinase activity

0050919:negative chemotaxis

0002053:positive regulation of mesenchymal cell proliferation

0035793:positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway

Drugbank NA
KEGG hsa:5154

Related Compounds  (Total: 2)

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Name: puerarin
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Name: berberine

Related Herbs  (Total: 0)

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