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Target Description
Type
Detail
Target ID
T88EIE
Protein Name
Platelet-derived growth factor subunit A
Uniprot ID
P04085
Protein Name Alias
PDGF subunit A; PDGF-1; Platelet-derived growth factor A chain; Platelet-derived growth factor alpha polypeptide
Gene ID
5154
Gene Symbol
PDGFA
Gene Alias
PDGF1
TTD
T06869: Clinical Trial target
Pfam
PF00341
;
PF04692
GO
0048407:platelet-derived growth factor binding
0070851:growth factor receptor binding
0005902:microvillus
0001775:cell activation
0043410:positive regulation of MAPK cascade
0005796:Golgi lumen
0000165:MAPK cascade
0005615:extracellular space
0060683:regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling
0043588:skin development
0014910:regulation of smooth muscle cell migration
0048146:positive regulation of fibroblast proliferation
0032956:regulation of actin cytoskeleton organization
1990401:embryonic lung development
0009986:cell surface
0030031:cell projection assembly
0001525:angiogenesis
0030036:actin cytoskeleton organization
0002576:platelet degranulation
0005161:platelet-derived growth factor receptor binding
0009611:response to wounding
0042802:identical protein binding
0046982:protein heterodimerization activity
0005576:extracellular region
0001942:hair follicle development
0008083:growth factor activity
0007267:cell-cell signaling
0048008:platelet-derived growth factor receptor signaling pathway
0010544:negative regulation of platelet activation
0031093:platelet alpha granule lumen
0030335:positive regulation of cell migration
0005518:collagen binding
0042803:protein homodimerization activity
0031954:positive regulation of protein autophosphorylation
0008284:positive regulation of cell population proliferation
0070374:positive regulation of ERK1 and ERK2 cascade
0009887:animal organ morphogenesis
0042060:wound healing
0030198:extracellular matrix organization
0005788:endoplasmic reticulum lumen
0010512:negative regulation of phosphatidylinositol biosynthetic process
0014068:positive regulation of phosphatidylinositol 3-kinase signaling
0000139:Golgi membrane
0048286:lung alveolus development
0051781:positive regulation of cell division
0050730:regulation of peptidyl-tyrosine phosphorylation
0051897:positive regulation of protein kinase B signaling
0043406:positive regulation of MAP kinase activity
0050919:negative chemotaxis
0002053:positive regulation of mesenchymal cell proliferation
0035793:positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
PDB
3MJK
Drugbank
NA
KEGG
hsa:5154
Related Compounds (Total: 2)
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C1017
Name: puerarin
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C1138
Name: berberine
Related Herbs (Total: 0)
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English Name
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