HIT-result

Target Description

Type	Detail
Target ID	T02U6A
Protein Name	Metabotropic glutamate receptor 1
Uniprot ID	Q13255
Protein Name Alias	mGluR1
Gene ID	2911
Gene Symbol	GRM1
Gene Alias	GPRC1A; MGLUR1
TTD	T27137: Discontinued target
Pfam	PF07562 ; PF10606 ; PF00003 ; PF01094
GO	0008066:glutamate receptor activity 0051482:positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway 0038038:G protein-coupled receptor homodimeric complex 0007626:locomotory behavior 0007268:chemical synaptic transmission 0071257:cellular response to electrical stimulus 0007186:G protein-coupled receptor signaling pathway 0099530:G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential 0001640:adenylate cyclase inhibiting G protein-coupled glutamate receptor activity 0042802:identical protein binding 0098685:Schaffer collateral - CA1 synapse 0007216:G protein-coupled glutamate receptor signaling pathway 0005886:plasma membrane 0004930:G protein-coupled receptor activity 0098712:L-glutamate import across plasma membrane 0098978:glutamatergic synapse 0005887:integral component of plasma membrane 0098872:G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration 0000186:activation of MAPKK activity 0030425:dendrite 0051966:regulation of synaptic transmission, glutamatergic 0098839:postsynaptic density membrane 0038037:G protein-coupled receptor dimeric complex 0005634:nucleus 0051930:regulation of sensory perception of pain 0019233:sensory perception of pain 0000187:activation of MAPK activity 0099583:neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration
PDB	4OR2 ; 3KS9
Drugbank	DB00142 ; DB04256
KEGG	hsa:2911

Type

Detail

Target ID

T02U6A

Protein Name

Metabotropic glutamate receptor 1

Uniprot ID

Q13255

Protein Name Alias

mGluR1

Gene ID

2911

Gene Symbol

GRM1

Gene Alias

GPRC1A; MGLUR1

TTD

T27137: Discontinued target

Pfam

PF07562 ; PF10606 ; PF00003 ; PF01094

0008066:glutamate receptor activity

0051482:positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway

0038038:G protein-coupled receptor homodimeric complex

0007626:locomotory behavior

0007268:chemical synaptic transmission

0071257:cellular response to electrical stimulus

0007186:G protein-coupled receptor signaling pathway

0099530:G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential

0001640:adenylate cyclase inhibiting G protein-coupled glutamate receptor activity

0042802:identical protein binding

0098685:Schaffer collateral - CA1 synapse

0007216:G protein-coupled glutamate receptor signaling pathway

0005886:plasma membrane

0004930:G protein-coupled receptor activity

0098712:L-glutamate import across plasma membrane

0098978:glutamatergic synapse

0005887:integral component of plasma membrane

0098872:G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration

0000186:activation of MAPKK activity

0030425:dendrite

0051966:regulation of synaptic transmission, glutamatergic

0098839:postsynaptic density membrane

0038037:G protein-coupled receptor dimeric complex

0005634:nucleus

0051930:regulation of sensory perception of pain

0019233:sensory perception of pain

0000187:activation of MAPK activity

0099583:neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration

PDB

4OR2 ; 3KS9

Drugbank

DB00142 ; DB04256

KEGG

hsa:2911

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0269	Mu Gua	木瓜	Chinese floweringquince	Chaenomeles sinensis
H0219	Man Shan Hong	满山红	Dahurian rhododendron	Rhododendron dauricum
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0706	Yan Hu Suo	延胡索	Yanhusuo	Corydalis yanhusuo
H0164	Ban Zhi Lian	半枝莲	Barbed skullcap	Scutellaria barbata
H1087	Gan Sui	甘遂	Kansui euphorbia	Euphorbia kansui
H0696	Ya Jiao Ai	鸭脚艾	Ghostplant wormwood	Artemisia lactiflora
H0456	Bu Gu Zhi	补骨脂	Malaytea scurfpea	Psoralea corylifolia
H0793	Zhao Shan Bai	照山白	Manchurian rhododendron	Rhododendron micranthum
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0784	Chi Shao	赤芍	Red peony root	Paeonia obovata
H0565	Tu Bie Chong	土鳖虫	Cockroach	Eupolyphaga sinensis
H1201	Hu Er Cao	虎耳草	Creeping rockfoil	Saxifraga stolonifera
H0429	Shao Yao	芍药	Red peony root	Paeonia obovata
H0633	Xia Tian Wu	夏天无	Decumbent corydalis	Corydalis decumbens
H0214	Bei He Huan	北合欢	Albizia	Albizia julibrissin
H0498	Si Ji Cai	四季菜	Ghostplant wormwood	Artemisia lactiflora
H0871	Chuan Duan	川断	Teasels	Dipsacus asper
H0636	Xian Mao	仙茅	Common cruculigo	Curculigo orchioides

Target Description

Related Compounds (Total: 4)

Related Herbs (Total: 19)