Target Description

Type Detail
Target ID T08KXM
Protein Name Low-density lipoprotein receptor-related protein 5
Uniprot ID O75197
Protein Name Alias LRP-5;  Low-density lipoprotein receptor-related protein 7;  LRP-7
Gene ID 4041
Gene Symbol LRP5
Gene Alias LR3;  LRP7
TTD T86072: Clinical Trial target
Pfam PF00057 ; PF00058
GO
1902262:apoptotic process involved in blood vessel morphogenesis

0043235:receptor complex

0042981:regulation of apoptotic process

0017147:Wnt-protein binding

1990851:Wnt-Frizzled-LRP5/6 complex

0045840:positive regulation of mitotic nuclear division

0005783:endoplasmic reticulum

0015026:coreceptor activity

0043434:response to peptide hormone

1901998:toxin transport

0046849:bone remodeling

0060349:bone morphogenesis

0035019:somatic stem cell population maintenance

0061304:retinal blood vessel morphogenesis

0060764:cell-cell signaling involved in mammary gland development

0008284:positive regulation of cell population proliferation

0060444:branching involved in mammary gland duct morphogenesis

0033690:positive regulation of osteoblast proliferation

0042733:embryonic digit morphogenesis

0110135:Norrin signaling pathway

0042813:Wnt-activated receptor activity

0045600:positive regulation of fat cell differentiation

0071936:coreceptor activity involved in Wnt signaling pathway

0042074:cell migration involved in gastrulation

0071901:negative regulation of protein serine/threonine kinase activity

0060070:canonical Wnt signaling pathway

0009314:response to radiation

0002053:positive regulation of mesenchymal cell proliferation

0005886:plasma membrane

0060042:retina morphogenesis in camera-type eye

0061178:regulation of insulin secretion involved in cellular response to glucose stimulus

1990909:Wnt signalosome

0016021:integral component of membrane

0006007:glucose catabolic process

1904928:coreceptor activity involved in canonical Wnt signaling pathway

0009952:anterior/posterior pattern specification

0042632:cholesterol homeostasis

0035426:extracellular matrix-cell signaling

0048539:bone marrow development

0060612:adipose tissue development

0045668:negative regulation of osteoblast differentiation

0045669:positive regulation of osteoblast differentiation

0045893:positive regulation of transcription, DNA-templated

0051091:positive regulation of DNA-binding transcription factor activity

0006897:endocytosis

0060033:anatomical structure regression

0008217:regulation of blood pressure

0002076:osteoblast development

0045944:positive regulation of transcription by RNA polymerase II

0008203:cholesterol metabolic process

0001702:gastrulation with mouth forming second

PDB NA
Drugbank NA
KEGG hsa:4041

Related Compounds  (Total: 3)

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C0025
Name: Dioscin
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C0814
Name: Collettiside Iii
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C0886
Name: Dioscin


Related Herbs  (Total: 13)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0278 Nan Ban Lan Gen Jin Gao Fen南板蓝根浸膏粉 Indigowoad rootBaphicacanthus cusia
H0866 Chuan Bi Xie川萆薢 Sichuan castor seedDioscorea septemloba
H0932 Ba Qia菝葜 Chinaroot greenbrierSmilax china
H0543 Tian Men Dong天门冬 Cochinchinese asparagusAsparagus cochinchinensis
H0570 Tu Fu Ling土茯苓 Glabrous greenbrierSmilax glabra
H0882 Chuan Shan Long穿山龙 Ningpo yam rhizomeRhizoma dioscoreae nipponicae
H0277 Nan Ban Lan Gen南板蓝根 Indigowoad rootBaphicacanthus cusia
H0172 Lu Gen芦根 Common reed rhizomePhragmites communis
H0874 Chuan Long Shu Yu穿龙薯蓣 Nippon yamDioscorea nipponica
H0705 Yan Hu Lu Ba盐胡芦巴 FenugreekTrigonella foenum-graecum
H0820 Chong Lou重楼 Paris rootRhizoma paridis
H0372 San Bai Bang三百棒 Chinese asparagusAsparagus cochinchinensis
H0537 Tian Dong天冬 Cochinchinese asparagus rootAsparagus cochinchinensis