Compound Description

ID:   C0025 Common name:   Dioscin
IUPAC:  NA CAS:  CAS:19057-60-4
Chembl ID:   CHEMBL507001 Pubchem ID:   CID:119245
Formula:  C45H72O16 TCM-ID:  TCMC1063
Smiles:  OC[C@H]1O[C@@H](O[C@H]2CC[C@]3(C(=CC[C@@H]4[C@@H]3CC[C@]3([C@H]4C[C@H]4[C@@H]3[C@H](C)[C@]3(O4)CC[C@H](CO3)C)C)C2)C)[C@@H]([C@H]([C@@H]1O[C@@H]1O[C@@H](C)[C@@H]([C@H]([C@H]1O)O)O)O)O[C@@H]1O[C@@H](C)[C@@H]([C@H]([C@H]1O)O)O
Alias:

Dioscin;

(3β,25R)-Spirost-5-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[6-deoxy-α-L-mannopyranosyl-(1→4)]-β-D-glucopyranoside;

(+)-Dioscin;

3-O-β-D-α-L-Rhamnopyranosyl(1→4)-[α-L-rhamnopyranosyl(1→2)]-β-D-glucopyranoside-diosgenin;

Collettiside III;

Dioscine;

Diosgenin 3-O-α-L-rhamnopyranosyl-(1→2)-[α-L-rhamnopyranosyl-(1→4)]-β-D-glucopyranoside;

Diosgenin 3-O-α-L-rhamnopyranosyl-(1→4)-[α-L-rhamnopyranosyl-(1→2)]-β-D-glucopyranoside;

Diosgenin bis-α-L-rhamnopyranosyl-(1→2 and 1→4)-β-D-glucopyranoside;

Paris III;

Parissaponin III;

Polyphyllin III
Structure:

Related Targets  (Total: 16)

Target idProtein NameGene SymbolUniprot IDTarget LevelNo.of Literature Evidence
T24C0P Bile acid receptorNR1H4 Q96RI1
A 1 Reference(s)
T16MRU NACHT, LRR and PYD domains-containing protein 3NLRP3 Q96P20
A 1 Reference(s)
T13HKH Integrin alpha-5ITGA5 P08648
A 1 Reference(s)
T84W8G Aryl hydrocarbon receptorAHR P35869
A 1 Reference(s)
T88TDZ RAC-alpha serine/threonine-protein kinaseAKT1 P31749
B 1 Reference(s)
T36YWU Kelch-like ECH-associated protein 1KEAP1 Q14145
B 1 Reference(s)
T76B0A Gap junction alpha-1 proteinGJA1 P17302
B 1 Reference(s)
T93YV8 Tumor necrosis factor receptor superfamily member 11BTNFRSF11B O00300
B 1 Reference(s)
T34X07 CCAAT/enhancer-binding protein alphaCEBPA P49715
C 1 Reference(s)
T51RTI NAHOTAIR NA
C 1 Reference(s)
T08KXM Low-density lipoprotein receptor-related protein 5LRP5 O75197
C 1 Reference(s)
T05AAL Microphthalmia-associated transcription factorMITF O75030
C 1 Reference(s)
T72KIO Peroxiredoxin-1PRDX1 Q06830
C 1 Reference(s)
T96OOK Signal transducer and activator of transcription 3STAT3 P40763
C 1 Reference(s)
T92BZ2 Catenin beta-1CTNNB1 P35222
C 1 Reference(s)
T05O6O Estrogen receptor betaESR2 Q92731
C 1 Reference(s)

*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".

Related Herbs  (Total: 11)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0277 Nan Ban Lan Gen南板蓝根 Indigowoad rootBaphicacanthus cusia
H0537 Tian Dong天冬 Cochinchinese asparagus rootAsparagus cochinchinensis
H0372 San Bai Bang三百棒 Chinese asparagusAsparagus cochinchinensis
H0705 Yan Hu Lu Ba盐胡芦巴 FenugreekTrigonella foenum-graecum
H0932 Ba Qia菝葜 Chinaroot greenbrierSmilax china
H0278 Nan Ban Lan Gen Jin Gao Fen南板蓝根浸膏粉 Indigowoad rootBaphicacanthus cusia
H0570 Tu Fu Ling土茯苓 Glabrous greenbrierSmilax glabra
H0820 Chong Lou重楼 Paris rootRhizoma paridis
H0866 Chuan Bi Xie川萆薢 Sichuan castor seedDioscorea septemloba
H0543 Tian Men Dong天门冬 Cochinchinese asparagusAsparagus cochinchinensis
H0874 Chuan Long Shu Yu穿龙薯蓣 Nippon yamDioscorea nipponica