HIT-result

Type	Detail
Target ID	T13HKH
Protein Name	Integrin alpha-5
Uniprot ID	P08648
Protein Name Alias	CD49 antigen-like family member E; Fibronectin receptor subunit alpha; Integrin alpha-F; VLA-5; CD antigen CD49e
Gene ID	3678
Gene Symbol	ITGA5
Gene Alias	FNRA
TTD	T29879: Clinical Trial target
Pfam	PF08441 ; PF01839
GO	0001726:ruffle 0023035:CD40 signaling pathway 0045202:synapse 0001525:angiogenesis 2000811:negative regulation of anoikis 0046872:metal ion binding 0007159:leukocyte cell-cell adhesion 0034674:integrin alpha5-beta1 complex 1903672:positive regulation of sprouting angiogenesis 0071062:alphav-beta3 integrin-vitronectin complex 0033627:cell adhesion mediated by integrin 0005154:epidermal growth factor receptor binding 0009897:external side of plasma membrane 0050731:positive regulation of peptidyl-tyrosine phosphorylation 0050900:leukocyte migration 0005783:endoplasmic reticulum 0009986:cell surface 0007229:integrin-mediated signaling pathway 0007157:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules 0035313:wound healing, spreading of epidermal cells 0035987:endodermal cell differentiation 0005161:platelet-derived growth factor receptor binding 0031410:cytoplasmic vesicle 0030335:positive regulation of cell migration 0030198:extracellular matrix organization 0005925:focal adhesion 0034113:heterotypic cell-cell adhesion 0033631:cell-cell adhesion mediated by integrin 0031589:cell-substrate adhesion 0007613:memory 0005178:integrin binding 0005886:plasma membrane 0001618:virus receptor activity 0005794:Golgi apparatus 0007155:cell adhesion 0030949:positive regulation of vascular endothelial growth factor receptor signaling pathway 0008305:integrin complex 0043184:vascular endothelial growth factor receptor 2 binding 0010811:positive regulation of cell-substrate adhesion 0007565:female pregnancy 0007044:cell-substrate junction assembly
PDB	4WK0 ; 3VI3 ; 4WJK ; 4WK4 ; 3VI4 ; 4WK2
Drugbank	DB02709
KEGG	hsa:3678

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Name: Dioscin

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Name: vinblastine

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0277	Nan Ban Lan Gen	南板蓝根	Indigowoad root	Baphicacanthus cusia
H0537	Tian Dong	天冬	Cochinchinese asparagus root	Asparagus cochinchinensis
H0372	San Bai Bang	三百棒	Chinese asparagus	Asparagus cochinchinensis
H0705	Yan Hu Lu Ba	盐胡芦巴	Fenugreek	Trigonella foenum-graecum
H0932	Ba Qia	菝葜	Chinaroot greenbrier	Smilax china
H0278	Nan Ban Lan Gen Jin Gao Fen	南板蓝根浸膏粉	Indigowoad root	Baphicacanthus cusia
H0570	Tu Fu Ling	土茯苓	Glabrous greenbrier	Smilax glabra
H0820	Chong Lou	重楼	Paris root	Rhizoma paridis
H0866	Chuan Bi Xie	川萆薢	Sichuan castor seed	Dioscorea septemloba
H0543	Tian Men Dong	天门冬	Cochinchinese asparagus	Asparagus cochinchinensis
H0874	Chuan Long Shu Yu	穿龙薯蓣	Nippon yam	Dioscorea nipponica