Target Description

Type Detail
Target ID T05AAL
Protein Name Microphthalmia-associated transcription factor
Uniprot ID O75030
Protein Name Alias Class E basic helix-loop-helix protein 32;  bHLHe32
Gene ID 4286
Gene Symbol MITF
Gene Alias BHLHE32
TTD NA
Pfam PF15951 ; PF11851 ; PF00010
GO
0005634:nucleus

0006351:transcription, DNA-templated

0030316:osteoclast differentiation

0044336:canonical Wnt signaling pathway involved in negative regulation of apoptotic process

0006355:regulation of transcription, DNA-templated

0030336:negative regulation of cell migration

0046849:bone remodeling

0042127:regulation of cell population proliferation

0045670:regulation of osteoclast differentiation

0003682:chromatin binding

2001141:regulation of RNA biosynthetic process

0043010:camera-type eye development

0005737:cytoplasm

0065003:protein-containing complex assembly

0030318:melanocyte differentiation

0001228:DNA-binding transcription activator activity, RNA polymerase II-specific

2000144:positive regulation of DNA-templated transcription, initiation

0045165:cell fate commitment

0010628:positive regulation of gene expression

0000785:chromatin

0070888:E-box binding

0046983:protein dimerization activity

0032991:protein-containing complex

0000981:DNA-binding transcription factor activity, RNA polymerase II-specific

0045893:positive regulation of transcription, DNA-templated

0000122:negative regulation of transcription by RNA polymerase II

0006357:regulation of transcription by RNA polymerase II

0000978:RNA polymerase II cis-regulatory region sequence-specific DNA binding

0005654:nucleoplasm

0001227:DNA-binding transcription repressor activity, RNA polymerase II-specific

0045944:positive regulation of transcription by RNA polymerase II

PDB 4C7N
Drugbank NA
KEGG hsa:4286

Related Compounds  (Total: 4)

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C0025
Name: Dioscin
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C0322
Name: Prasterone
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C0814
Name: Collettiside Iii
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C0886
Name: Dioscin


Related Herbs  (Total: 15)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0172 Lu Gen芦根 Common reed rhizomePhragmites communis
H0537 Tian Dong天冬 Cochinchinese asparagus rootAsparagus cochinchinensis
H0570 Tu Fu Ling土茯苓 Glabrous greenbrierSmilax glabra
H0874 Chuan Long Shu Yu穿龙薯蓣 Nippon yamDioscorea nipponica
H0932 Ba Qia菝葜 Chinaroot greenbrierSmilax china
H0372 San Bai Bang三百棒 Chinese asparagusAsparagus cochinchinensis
H0278 Nan Ban Lan Gen Jin Gao Fen南板蓝根浸膏粉 Indigowoad rootBaphicacanthus cusia
H0820 Chong Lou重楼 Paris rootRhizoma paridis
H0866 Chuan Bi Xie川萆薢 Sichuan castor seedDioscorea septemloba
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0705 Yan Hu Lu Ba盐胡芦巴 FenugreekTrigonella foenum-graecum
H0277 Nan Ban Lan Gen南板蓝根 Indigowoad rootBaphicacanthus cusia
H0882 Chuan Shan Long穿山龙 Ningpo yam rhizomeRhizoma dioscoreae nipponicae
H0543 Tian Men Dong天门冬 Cochinchinese asparagusAsparagus cochinchinensis