HIT-result

Type	Detail
Target ID	T19F7P
Protein Name	Proteinase-activated receptor 1
Uniprot ID	P25116
Protein Name Alias	PAR-1; Coagulation factor II receptor; Thrombin receptor
Gene ID	2149
Gene Symbol	F2R
Gene Alias	CF2R; PAR1; TR
TTD	T36483: Successful target
Pfam	PF00001
GO	0030193:regulation of blood coagulation 0031681:G-protein beta-subunit binding 0005794:Golgi apparatus 0007596:blood coagulation 0060155:platelet dense granule organization 0000186:activation of MAPKK activity 0005576:extracellular region 0008284:positive regulation of cell population proliferation 0006954:inflammatory response 0035025:positive regulation of Rho protein signal transduction 0003105:negative regulation of glomerular filtration 0005769:early endosome 0051209:release of sequestered calcium ion into cytosol 0004930:G protein-coupled receptor activity 0051482:positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway 0007529:establishment of synaptic specificity at neuromuscular junction 0051928:positive regulation of calcium ion transport 0005886:plasma membrane 0002248:connective tissue replacement involved in inflammatory response wound healing 0005901:caveola 0043524:negative regulation of neuron apoptotic process 1900134:negative regulation of renin secretion into blood stream 0030168:platelet activation 0007204:positive regulation of cytosolic calcium ion concentration 0045893:positive regulation of transcription, DNA-templated 0051930:regulation of sensory perception of pain 0031594:neuromuscular junction 0009653:anatomical structure morphogenesis 0009611:response to wounding 0099553:trans-synaptic signaling by endocannabinoid, modulating synaptic transmission 0045987:positive regulation of smooth muscle contraction 0032651:regulation of interleukin-1 beta production 0032755:positive regulation of interleukin-6 production 0032967:positive regulation of collagen biosynthetic process 0046427:positive regulation of receptor signaling pathway via JAK-STAT 0030194:positive regulation of blood coagulation 0006919:activation of cysteine-type endopeptidase activity involved in apoptotic process 0048873:homeostasis of number of cells within a tissue 0043280:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 0005102:signaling receptor binding 0045217:cell-cell junction maintenance 0045907:positive regulation of vasoconstriction 0015057:thrombin-activated receptor activity 0045211:postsynaptic membrane 0043410:positive regulation of MAPK cascade 0007200:phospholipase C-activating G protein-coupled receptor signaling pathway 0030335:positive regulation of cell migration 0008285:negative regulation of cell population proliferation 0014068:positive regulation of phosphatidylinositol 3-kinase signaling 0051281:positive regulation of release of sequestered calcium ion into cytosol 0043123:positive regulation of I-kappaB kinase/NF-kappaB signaling 0031094:platelet dense tubular network 0009986:cell surface 0005887:integral component of plasma membrane 0043547:positive regulation of GTPase activity 0001965:G-protein alpha-subunit binding 0032496:response to lipopolysaccharide 0070374:positive regulation of ERK1 and ERK2 cascade 0007186:G protein-coupled receptor signaling pathway 0005770:late endosome 0032757:positive regulation of interleukin-8 production 0007205:protein kinase C-activating G protein-coupled receptor signaling pathway
PDB	3HKJ ; 1NRR ; 3LU9 ; 3BEF ; 3HKI ; 1NRP ; 1NRQ ; 3VW7 ; 1NRN ; 1NRO
Drugbank	DB00086 ; DB05361 ; DB09030 ; DB11300
KEGG	hsa:2149

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Name: puerarin

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0925	Da Fu Zi	大腹子	Areca palm	Areca catechu
H0033	Jiao Bing Lang	焦槟榔	Charred areca seed	Semen arecae preparata
H0924	Da Fu Pi	大腹皮	pericarp of betelnutpalm	Pericarpium arecae
H0408	Bing Lang	槟榔	Betenutpalm	Areca catechu