HIT-result

Type	Detail
Target ID	T30A57
Protein Name	C-C chemokine receptor type 7
Uniprot ID	P32248
Protein Name Alias	C-C CKR-7; CC-CKR-7; CCR-7; BLR2; CDw197; Epstein-Barr virus-induced G-protein coupled receptor 1; EBI1; EBV-induced G-protein coupled receptor 1; MIP-3 beta receptor; CD antigen CD197
Gene ID	1236
Gene Symbol	CCR7
Gene Alias	CMKBR7; EBI1; EVI1
TTD	T84981: Clinical Trial target
Pfam	PF00001
GO	2000669:negative regulation of dendritic cell apoptotic process 0097029:mature conventional dendritic cell differentiation 0051491:positive regulation of filopodium assembly 0016021:integral component of membrane 0097022:lymphocyte migration into lymph node 0007204:positive regulation of cytosolic calcium ion concentration 0002408:myeloid dendritic cell chemotaxis 0031529:ruffle organization 0002922:positive regulation of humoral immune response 0045785:positive regulation of cell adhesion 0009986:cell surface 0032496:response to lipopolysaccharide 0007186:G protein-coupled receptor signaling pathway 0031274:positive regulation of pseudopodium assembly 0045060:negative thymic T cell selection 0051209:release of sequestered calcium ion into cytosol 0060326:cell chemotaxis 0090023:positive regulation of neutrophil chemotaxis 0016493:C-C chemokine receptor activity 0009897:external side of plasma membrane 0002407:dendritic cell chemotaxis 0071345:cellular response to cytokine stimulus 0090630:activation of GTPase activity 0043552:positive regulation of phosphatidylinositol 3-kinase activity 2000525:positive regulation of T cell costimulation 0002885:positive regulation of hypersensitivity 2000547:regulation of dendritic cell dendrite assembly 0032651:regulation of interleukin-1 beta production 0005886:plasma membrane 0004930:G protein-coupled receptor activity 0001768:establishment of T cell polarity 0046330:positive regulation of JNK cascade 0038117:C-C motif chemokine 19 receptor activity 0032695:negative regulation of interleukin-12 production 0001954:positive regulation of cell-matrix adhesion 2000522:positive regulation of immunological synapse formation 0005739:mitochondrion 0035757:chemokine (C-C motif) ligand 19 binding 0035758:chemokine (C-C motif) ligand 21 binding 2000147:positive regulation of cell motility 0002606:positive regulation of dendritic cell antigen processing and presentation 0034695:response to prostaglandin E 0006955:immune response 0032649:regulation of interferon-gamma production 0050862:positive regulation of T cell receptor signaling pathway 0070374:positive regulation of ERK1 and ERK2 cascade 2000526:positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation 2000510:positive regulation of dendritic cell chemotaxis 0043123:positive regulation of I-kappaB kinase/NF-kappaB signaling 0006954:inflammatory response 0038121:C-C motif chemokine 21 receptor activity 0071731:response to nitric oxide 0051897:positive regulation of protein kinase B signaling 0019722:calcium-mediated signaling 0032735:positive regulation of interleukin-12 production 0045860:positive regulation of protein kinase activity 0019957:C-C chemokine binding 0048872:homeostasis of number of cells 0030838:positive regulation of actin filament polymerization
PDB	6QZH
Drugbank	NA
KEGG	hsa:1236

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Name: Triptolide

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Name: Cholecalciferol

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0118	Kun Ming Shan Hai Tang	昆明山海棠	Glaucousback threewingnut	Tripterygium hypoglaucum
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens