HIT-result

Type	Detail
Target ID	T43R3A
Protein Name	TIR domain-containing adapter molecule 2
Uniprot ID	Q86XR7
Protein Name Alias	TICAM-2; Putative NF-kappa-B-activating protein 502; TRIF-related adapter molecule; Toll-like receptor adaptor protein 3; Toll/interleukin-1 receptor domain-containing protein; MyD88-4
Gene ID	353376
Gene Symbol	TICAM2
Gene Alias	TIRAP3; TIRP; TRAM
TTD	NA
Pfam	PF13676
GO	0030667:secretory granule membrane 0034142:toll-like receptor 4 signaling pathway 0071650:negative regulation of chemokine (C-C motif) ligand 5 production 0005770:late endosome 0030134:COPII-coated ER to Golgi transport vesicle 0045087:innate immune response 0071222:cellular response to lipopolysaccharide 0034144:negative regulation of toll-like receptor 4 signaling pathway 0034145:positive regulation of toll-like receptor 4 signaling pathway 2000494:positive regulation of interleukin-18-mediated signaling pathway 0070266:necroptotic process 0035669:TRAM-dependent toll-like receptor 4 signaling pathway 0006909:phagocytosis 0005783:endoplasmic reticulum 0005886:plasma membrane 0097190:apoptotic signaling pathway 0007030:Golgi organization 0043312:neutrophil degranulation 0043123:positive regulation of I-kappaB kinase/NF-kappaB signaling 0006954:inflammatory response 0005793:endoplasmic reticulum-Golgi intermediate compartment 0031901:early endosome membrane 0005794:Golgi apparatus 0005769:early endosome 0031902:late endosome membrane 0001891:phagocytic cup 0035666:TRIF-dependent toll-like receptor signaling pathway 0042995:cell projection 0006886:intracellular protein transport 0002756:MyD88-independent toll-like receptor signaling pathway 0007249:I-kappaB kinase/NF-kappaB signaling 0006888:endoplasmic reticulum to Golgi vesicle-mediated transport 0034128:negative regulation of MyD88-independent toll-like receptor signaling pathway 0071651:positive regulation of chemokine (C-C motif) ligand 5 production 0010008:endosome membrane
PDB	2M1W
Drugbank	NA
KEGG	hsa:100302736 ; hsa:353376

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0219	Man Shan Hong	满山红	Dahurian rhododendron	Rhododendron dauricum
H0743	Yi Zhi Ren	益智仁	Sharpleaf galangal	Alpinia oxyphylla
H1066	Gan Cao	甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1021	E Da Xia	莪大夏	NA	Oxytropis falcata
H1152	Bai Jie Zi	白芥子	White mustard seed	Sinapis alba
H1070	Gan Cao Gan Gao Fen	甘草干膏粉	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0446	Sheng Jiang	生姜	Fresh common ginger	Zingiber officinale
H0848	Zi Jin Niu	紫金牛	Japanese ardisia	Ardisia japonica
H0024	Jia 蒟ye	假蒟叶	Sarmentose pepper	Piper sarmentosum
H0235	Mao She Xiang	毛麝香	Abelmusk	Moschus moschiferus
H0740	Yi Zhi	益智	Fructus alpinae oxyphyllae	Alpinia oxyphylla
H0236	Mao She Xiang Jin Gao	毛麝香浸膏	Abelmusk	Moschus moschiferus
H0270	Mu Hu Die	木蝴蝶	Indian trumpetflower	Oroxylum indicum
H0437	She Xiang	麝香	Abelmusk	Moschus moschiferus
H0042	Bai Tou Weng	白头翁	Chinese pulsatilla	Pulsatilla chinensis
H1072	Gan Cao Gao	甘草膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1074	Gan Cao Jin Gao	甘草浸膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0356	Ren Gong She Xiang	人工麝香	Abelmusk	Moschus moschiferus
H1183	Hong Dou	红豆	Hosie ormosia	Ormosia hosiei
H0022	Jia Ju	假蒟	Sarmentose pepper	Piper sarmentosum
H1069	Gan Cao Gan Gao	甘草干膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0464	Shi Liu Zi	石榴子	NA	Punica granatum
H0154	Ai Ye You	艾叶油	Argy wormwood leaf	Artemisia argyi
H0444	Sheng Gan Cao	生甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1075	Gan Cao Liu Jin Gao	甘草流浸膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0574	Cao Dou Kou	草豆蔻	Katsumada galangal	Alpinia katsumadai
H0409	Shan Jiang	山姜	shell ginger	Alpinia zerumbet
H1073	Gan Cao Jie	甘草节	Glycyrrhiza uralensis fisch	Glycyrrhiza uralensis
H0463	Shi Liu Pi	石榴皮	Pomegranate peel	Punica granatum
H0582	Cao Dou Kou Ren	草豆蔻仁	Katsumada galangal	Alpinia katsumadai
H0144	Ban Li Ke	板栗壳	Chestnut shell	Castanea mollissima
H1067	Gan Cao Fen	甘草粉	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0515	Suan Shi Liu	酸石榴	Pomegranate	Punica granatum
H0438	Shen Jin Cao	伸筋草	Common japanese clubmoss	Lycopodium japonicum
H0462	Shi Liu	石榴	Pomegranate fruit	Punica granatum
H0571	Tu Gan Cao	土甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0103	Ai Ye	艾叶	Argy wormwood leaf	Artemisia argyi
H1071	Gan Cao Gan Jin Gao	甘草干浸膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1034	Fei Yang Cao	飞杨草	NA	Euphorbia hirta
H1042	Feng Shu Ye	枫树叶	Maple	Acer saccharum
H0240	Mi Gan Cao	蜜甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis

Target Description

Related Compounds (Total: 2)

Related Herbs (Total: 41)