HIT-result

Target Description

Type	Detail
Target ID	T06DT5
Protein Name	Phorbol-12-myristate-13-acetate-induced protein 1
Uniprot ID	Q13794
Protein Name Alias	PMA-induced protein 1; Immediate-early-response protein APR; Protein Noxa
Gene ID	5366
Gene Symbol	PMAIP1
Gene Alias	NOXA
TTD	NA
Pfam	PF15150
GO	0006915:apoptotic process 2001244:positive regulation of intrinsic apoptotic signaling pathway 0010907:positive regulation of glucose metabolic process 0010917:negative regulation of mitochondrial membrane potential 0090200:positive regulation of release of cytochrome c from mitochondria 0046902:regulation of mitochondrial membrane permeability 0072332:intrinsic apoptotic signaling pathway by p53 class mediator 0043331:response to dsRNA 1902237:positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 0043065:positive regulation of apoptotic process 0005739:mitochondrion 0005741:mitochondrial outer membrane 0005634:nucleus 0006919:activation of cysteine-type endopeptidase activity involved in apoptotic process 0043280:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 1900740:positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 0005829:cytosol 0043029:T cell homeostasis 1902043:positive regulation of extrinsic apoptotic signaling pathway via death domain receptors 0001844:protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 0043517:positive regulation of DNA damage response, signal transduction by p53 class mediator 0097193:intrinsic apoptotic signaling pathway 0001836:release of cytochrome c from mitochondria 0072593:reactive oxygen species metabolic process 0006974:cellular response to DNA damage stimulus 0010498:proteasomal protein catabolic process 0051607:defense response to virus 0042149:cellular response to glucose starvation 0042981:regulation of apoptotic process 0071456:cellular response to hypoxia
PDB	3MQP
Drugbank	NA
KEGG	hsa:5366

Type

Detail

Target ID

T06DT5

Protein Name

Phorbol-12-myristate-13-acetate-induced protein 1

Uniprot ID

Q13794

Protein Name Alias

PMA-induced protein 1; Immediate-early-response protein APR; Protein Noxa

Gene ID

5366

Gene Symbol

PMAIP1

Gene Alias

NOXA

TTD

Pfam

PF15150

0006915:apoptotic process

2001244:positive regulation of intrinsic apoptotic signaling pathway

0010907:positive regulation of glucose metabolic process

0010917:negative regulation of mitochondrial membrane potential

0090200:positive regulation of release of cytochrome c from mitochondria

0046902:regulation of mitochondrial membrane permeability

0072332:intrinsic apoptotic signaling pathway by p53 class mediator

0043331:response to dsRNA

1902237:positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

0043065:positive regulation of apoptotic process

0005739:mitochondrion

0005741:mitochondrial outer membrane

0005634:nucleus

0006919:activation of cysteine-type endopeptidase activity involved in apoptotic process

0043280:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

1900740:positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway

0005829:cytosol

0043029:T cell homeostasis

1902043:positive regulation of extrinsic apoptotic signaling pathway via death domain receptors

0001844:protein insertion into mitochondrial membrane involved in apoptotic signaling pathway

0043517:positive regulation of DNA damage response, signal transduction by p53 class mediator

0097193:intrinsic apoptotic signaling pathway

0001836:release of cytochrome c from mitochondria

0072593:reactive oxygen species metabolic process

0006974:cellular response to DNA damage stimulus

0010498:proteasomal protein catabolic process

0051607:defense response to virus

0042149:cellular response to glucose starvation

0042981:regulation of apoptotic process

0071456:cellular response to hypoxia

PDB

3MQP

Drugbank

KEGG

hsa:5366

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Name: Prasterone

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Name: Celastrol

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Name: denbinobin

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Name: Celastrol

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0284	Nan She Teng	南蛇藤	Oriental bittersweet	Celastrus orbiculatus
H0016	Ji Xue Cao	积雪草	Asiatic pennywort	Centella asiatica
H0130	Lei Gong Teng	雷公藤	Common threewingnut	Tripterygium wilfordii
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0353	Que Mei Teng Gen	雀梅藤根	Hedge sageretia	Sageretia thea
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H1244	Huang Miao	黄苗	NA	Taraxacum mongolicum
H0314	Pu Gong Ying	蒲公英	Mongolian dandelion	Taraxacum mongolicum
H0315	Pu Gong Ying Jin Gao	蒲公英浸膏	Mongolian dandelion	Taraxacum mongolicum

Target Description

Related Compounds (Total: 4)

Related Herbs (Total: 9)