Compound Description
| ID: C1246 | Common name: Citric Acid |
| IUPAC: 2-hydroxypropane-1,2,3-tricarboxylic acid | CAS: CAS:77-92-9 |
| Chembl ID: CHEMBL1261 | Pubchem ID: CID:311 |
| Formula: C6H8O7 | TCM-ID: TCMC923 |
| Smiles: C(C(=O)O)C(CC(=O)O)(C(=O)O)O | |
| Alias:
Citric acid;
2-Hydroxy-1,2,3-propanetricarboxylic acid; 2-Hydroxy-1,2,3-propanetricarboxyic acid; 2-Hydroxypropan-1,2,3-tricarboxylic acid; 3-Carboxy-3-hydroxypentane-1,5-dioic acid; 3-Hydroxy-3-carboxy-1,5-pentanedioic acid; 3-Hydroxy-pentane-1,3-5-trioic acid |
Structure:
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Related Targets (Total: 7)
| Target id | Protein Name | Gene Symbol | Uniprot ID | Target Level | No.of Literature Evidence |
|---|---|---|---|---|---|
| T38N54 | Fumarate hydratase, mitochondrial | FH |
P07954 |
A | 1 Reference(s) |
| T18VDI | Apoptosis-inducing factor 1, mitochondrial | AIFM1 |
O95831 |
A | 1 Reference(s) |
| T62KUY | Endonuclease G, mitochondrial | ENDOG |
Q14249 |
A | 1 Reference(s) |
| T90ADC | BH3-interacting domain death agonist | BID |
P55957 |
A | 1 Reference(s) |
| T76AZQ | Histidine decarboxylase | HDC |
P19113 |
C | 1 Reference(s) |
| T38T1U | Caspase-8 | CASP8 |
Q14790 |
C | 1 Reference(s) |
| T30VNV | Myeloperoxidase | MPO |
P05164 |
C | 1 Reference(s) |
*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Related Herbs (Total: 66)
| Herb id | Chinese Pin Yin | Chinese Character | English Name | Latin Name |
|---|---|---|---|---|
| H0679 | Xing Ren | 杏仁 | Apricot seed | Prunus armeniaca |
| H0269 | Mu Gua | 木瓜 | Chinese floweringquince | Chaenomeles sinensis |
| H0941 | Da Zao | 大枣 | Chinese date | Ziziphus jujuba |
| H0610 | Wu Xiang Xue Teng | 五香血藤 | longpeduncle kadsura stem | Schisandra sphenanthera |
| H0463 | Shi Liu Pi | 石榴皮 | Pomegranate peel | Punica granatum |
| H0358 | Ren Shen Ye | 人参叶 | Ginseng leaf | Panax ginseng |
| H0060 | Jin Si Ku Lian | 金丝苦楝 | NA | Cardiospermum halicacabum |
| H1217 | Bai Mei Hua | 白梅花 | Japanese apricot flower | Prunus mume |
| H0422 | Shan Zha Tan | 山楂炭 | Chinese hawthorn | Crataegus pinnatifida |
| H0607 | Wu Wei Zi Jin Chu Wu | 五味子浸出物 | Five-flavor berry | Schisandra chinensis |
| H0419 | Shan Zha | 山楂 | Chinese hawthorn | Crataegus pinnatifida |
| H1036 | Fen Dan Pi | 粉丹皮 | Tree peony bark | Paeonia suffruticosa |
| H1213 | Hu Zhang | 虎杖 | Japanese fleeceflower | Polygonum cuspidatum |
| H0226 | Man Yue Mei | 蔓越莓 | Cranberry | Vaccinium oxycoccos |
| H0357 | Ren Shen | 人参 | Ginseng | Panax ginseng |
| H0802 | Zhi Geng | 枳梗 | NA | Citrus aurantium |
| H0956 | Dang Gui Gan Jin Gao | 当归干浸膏 | NA | Angelica sinensis |
| H0542 | Tian Ma | 天麻 | Tall gastrodia | Gastrodia elata |
| H0757 | Ying Su Ke | 罂粟壳 | Opium poppy pericarp | Papaver somniferum |
| H0360 | Ren Zhong Bai | 人中白 | Human urine sediment | Homo sapiens |
| H0083 | Jiu Jie Cha | 九节茶 | Glabrous sarcandra | Sarcandra glabra |
| H0004 | Huo Xiang | 藿香 | Patchouli | Pogostemon cablin |
| H0248 | Mi Ying Su Ke | 蜜罂粟壳 | Opium poppy | Papaver somniferum |
| H0461 | Shi Jun Zi Ren | 使君子仁 | NA | Combretum indicum |
| H0421 | Shan Zha Qing Gao | 山楂清膏 | Chinese hawthorn | Crataegus pinnatifida |
| H0605 | Wu Wei Zi | 五味子 | Chinese magnoliavine | Schisandra chinensis |
| H0804 | Zhi Ke | 枳壳 | Seville ora nge unripe fruit | Citrus aurantium |
| H1127 | Guang Shan Zha | 广山楂 | Chinese hawthorn | Crataegus pinnatifida |
| H0958 | Dang Shen | 党参 | Pilose asiabell | Codonopsis pilosula |
| H0805 | Zhi Ke Gan Jin Gao | 枳壳干浸膏 | Seville ora nge unripe fruit | Citrus aurantium |
| H1232 | Huang Cao Wu | 黄草乌 | NA | Aconitum vilmorinianum |
| H0606 | Wu Wei Zi Chun Jin Gao | 五味子醇浸膏 | Five-flavor berry | Schisandra chinensis |
| H0758 | Cheng Pi | 橙皮 | Bitter orange | Citrus aurantium |
| H0243 | Mi Kuan Dong Hua | 蜜款冬花 | Common coltsfoot | Tussilago farfara |
| H0756 | Ying Su | 罂粟 | Opium poppy | Papaver somniferum |
| H0602 | Wu Mei Rou | 乌梅肉 | Ebony | Prunus mume |
| H0572 | Tu Huo Xiang | 土藿香 | Patchouli | Pogostemon cablin |
| H0650 | Chai Hu | 柴胡 | Chinese thorowax | Bupleurum chinense |
| H0714 | Yan Tai Chai Hu | 烟台柴胡 | Chinese thorowax | Bupleurum chinense |
| H0847 | Zi He Che | 紫河车 | Human placenta | Homo sapiens |
| H0670 | Chai Pi Zhang | 豺皮樟 | Oblong-leaved litsea | Litsea rotundifolia |
| H0955 | Dang Gui | 当归 | Chinese angelica | Angelica sinensis |
| H0813 | Zhi Shi | 枳实 | Seville orange young fruit | Citrus aurantium |
| H0612 | Cao Shan Hu Jin Gao | 草珊瑚浸膏 | NA | Sarcandra glabra |
| H1120 | Guang Huo Xiang | 广藿香 | Patchouli | Pogostemon cablin |
| H0420 | Shan Zha Chou Gao | 山楂稠膏 | Chinese hawthorn | Crataegus pinnatifida |
| H0005 | Huo Xiang Ye | 藿香叶 | Patchouli | Pogostemon cablin |
| H0601 | Wu Mei | 乌梅 | Japanese apricot | Prunus mume |
| H0115 | Kuan Dong Hua | 款冬花 | Common coltsfoot | Tussilago farfara |
| H0609 | Wu Wei Zi Liu Jin Gao | 五味子流浸膏 | Five-flavor berry | Schisandra chinensis |
| H0651 | Xiang Yuan | 香橼 | Wilson citron | Citrus medica |
| H0665 | Chai Hu Shao | 柴胡梢 | Chinese thorowax | Bupleurum chinense |
| H0960 | Dang Shen Qing Gao | 党参清膏 | Root of hairy asiabell | Codonopsis pilosula |
| H0940 | Da Ye Zi Zhu | 大叶紫珠 | Bigleaf beautyberry | Callicarpa macrophylla |
| H0006 | Bai Qu Cai | 白屈菜 | Greater celandine | Chelidonium majus |
| H0659 | Chai Hu Jin Gao | 柴胡浸膏 | Chinese thorowax | Bupleurum chinense |
| H1010 | Du Huo Xiang | 杜藿香 | Patchouli | Pogostemon cablin |
| H0608 | Wu Wei Zi Jin Gao | 五味子浸膏 | Five-flavor berry | Schisandra chinensis |
| H0227 | Mang Guo Ye | 芒果叶 | Mango leaf | Mangifera indica |
| H0462 | Shi Liu | 石榴 | Pomegranate fruit | Punica granatum |
| H0515 | Suan Shi Liu | 酸石榴 | Pomegranate | Punica granatum |
| H0416 | Shan Shen | 山参 | NA | Panax ginseng |
| H0733 | Ye Shan Zha | 野山楂 | nippon bawthorn | Crataegus pinnatifida |
| H0652 | Xiang Yuan Pi | 香橼皮 | Wilson citron | Citrus medica |
| H0464 | Shi Liu Zi | 石榴子 | NA | Punica granatum |
| H0626 | Xi Nan Huang Qin | 西南黄芩 | Yunnan skullcap | Scutellaria amoena |
Ckey description of the interaction between compound and target