HIT-result

Target Description

Type	Detail
Target ID	T01HJQ
Protein Name	Calreticulin
Uniprot ID	P27797
Protein Name Alias	CRP55; Calregulin; Endoplasmic reticulum resident protein 60; ERp60; HACBP; grp60
Gene ID	811
Gene Symbol	CALR
Gene Alias	CRTC
TTD	T79821: Research target
Pfam	PF00262
GO	0005178:integrin binding 0009986:cell surface 0006457:protein folding 0003729:mRNA binding 0005925:focal adhesion 0005576:extracellular region 0007283:spermatogenesis 0071556:integral component of lumenal side of endoplasmic reticulum membrane 0048387:negative regulation of retinoic acid receptor signaling pathway 0032355:response to estradiol 0050681:androgen receptor binding 0036500:ATF6-mediated unfolded protein response 1990668:vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane 0071285:cellular response to lithium ion 0001849:complement component C1q complex binding 0051082:unfolded protein binding 0006874:cellular calcium ion homeostasis 0010595:positive regulation of endothelial cell migration 0006355:regulation of transcription, DNA-templated 0051087:chaperone binding 0002502:peptide antigen assembly with MHC class I protein complex 0042921:glucocorticoid receptor signaling pathway 0051208:sequestering of calcium ion 0050821:protein stabilization 0042824:MHC class I peptide loading complex 0005790:smooth endoplasmic reticulum 0030670:phagocytic vesicle membrane 0048471:perinuclear region of cytoplasm 0005783:endoplasmic reticulum 0003723:RNA binding 0033018:sarcoplasmic reticulum lumen 1900026:positive regulation of substrate adhesion-dependent cell spreading 0022417:protein maturation by protein folding 0008284:positive regulation of cell population proliferation 0005509:calcium ion binding 0045787:positive regulation of cell cycle 0017148:negative regulation of translation 0055007:cardiac muscle cell differentiation 0000122:negative regulation of transcription by RNA polymerase II 0006611:protein export from nucleus 0042493:response to drug 0031625:ubiquitin protein ligase binding 0030968:endoplasmic reticulum unfolded protein response 0016020:membrane 0042562:hormone binding 0001669:acrosomal vesicle 0042981:regulation of apoptotic process 0030866:cortical actin cytoskeleton organization 0033574:response to testosterone 0042277:peptide binding 0006898:receptor-mediated endocytosis 0071682:endocytic vesicle lumen 0005844:polysome 0003677:DNA binding 0008270:zinc ion binding 0005506:iron ion binding 0034504:protein localization to nucleus 0044183:protein folding chaperone 0005634:nucleus 1901164:negative regulation of trophoblast cell migration 0002474:antigen processing and presentation of peptide antigen via MHC class I 2000510:positive regulation of dendritic cell chemotaxis 0010628:positive regulation of gene expression 0050766:positive regulation of phagocytosis 0005788:endoplasmic reticulum lumen 0044322:endoplasmic reticulum quality control compartment 0071157:negative regulation of cell cycle arrest 0005635:nuclear envelope 0070062:extracellular exosome 0030246:carbohydrate binding 0005789:endoplasmic reticulum membrane 0005615:extracellular space 1901224:positive regulation of NIK/NF-kappaB signaling 0033116:endoplasmic reticulum-Golgi intermediate compartment membrane 0005829:cytosol 0002479:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent 0033144:negative regulation of intracellular steroid hormone receptor signaling pathway 0009897:external side of plasma membrane 0040020:regulation of meiotic nuclear division 0062023:collagen-containing extracellular matrix 0005794:Golgi apparatus 0005737:cytoplasm 0090398:cellular senescence 0045892:negative regulation of transcription, DNA-templated 0060473:cortical granule 0034975:protein folding in endoplasmic reticulum 0045665:negative regulation of neuron differentiation
PDB	3POW ; 3POS ; 5V90 ; 3DOW ; 5LK5 ; 2CLR ; 6ENY
Drugbank	DB09130 ; DB01065 ; DB13999 ; DB00025 ; DB00031 ; DB13998 ; DB14520 ; DB06245 ; DB11093 ; DB14481 ; DB13949 ; DB11348
KEGG	hsa:811

Type

Detail

Target ID

T01HJQ

Protein Name

Calreticulin

Uniprot ID

P27797

Protein Name Alias

CRP55; Calregulin; Endoplasmic reticulum resident protein 60; ERp60; HACBP; grp60

Gene ID

811

Gene Symbol

CALR

Gene Alias

CRTC

TTD

T79821: Research target

Pfam

PF00262

0005178:integrin binding

0009986:cell surface

0006457:protein folding

0003729:mRNA binding

0005925:focal adhesion

0005576:extracellular region

0007283:spermatogenesis

0071556:integral component of lumenal side of endoplasmic reticulum membrane

0048387:negative regulation of retinoic acid receptor signaling pathway

0032355:response to estradiol

0050681:androgen receptor binding

0036500:ATF6-mediated unfolded protein response

1990668:vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane

0071285:cellular response to lithium ion

0001849:complement component C1q complex binding

0051082:unfolded protein binding

0006874:cellular calcium ion homeostasis

0010595:positive regulation of endothelial cell migration

0006355:regulation of transcription, DNA-templated

0051087:chaperone binding

0002502:peptide antigen assembly with MHC class I protein complex

0042921:glucocorticoid receptor signaling pathway

0051208:sequestering of calcium ion

0050821:protein stabilization

0042824:MHC class I peptide loading complex

0005790:smooth endoplasmic reticulum

0030670:phagocytic vesicle membrane

0048471:perinuclear region of cytoplasm

0005783:endoplasmic reticulum

0003723:RNA binding

0033018:sarcoplasmic reticulum lumen

1900026:positive regulation of substrate adhesion-dependent cell spreading

0022417:protein maturation by protein folding

0008284:positive regulation of cell population proliferation

0005509:calcium ion binding

0045787:positive regulation of cell cycle

0017148:negative regulation of translation

0055007:cardiac muscle cell differentiation

0000122:negative regulation of transcription by RNA polymerase II

0006611:protein export from nucleus

0042493:response to drug

0031625:ubiquitin protein ligase binding

0030968:endoplasmic reticulum unfolded protein response

0016020:membrane

0042562:hormone binding

0001669:acrosomal vesicle

0042981:regulation of apoptotic process

0030866:cortical actin cytoskeleton organization

0033574:response to testosterone

0042277:peptide binding

0006898:receptor-mediated endocytosis

0071682:endocytic vesicle lumen

0005844:polysome

0003677:DNA binding

0008270:zinc ion binding

0005506:iron ion binding

0034504:protein localization to nucleus

0044183:protein folding chaperone

0005634:nucleus

1901164:negative regulation of trophoblast cell migration

0002474:antigen processing and presentation of peptide antigen via MHC class I

2000510:positive regulation of dendritic cell chemotaxis

0010628:positive regulation of gene expression

0050766:positive regulation of phagocytosis

0005788:endoplasmic reticulum lumen

0044322:endoplasmic reticulum quality control compartment

0071157:negative regulation of cell cycle arrest

0005635:nuclear envelope

0070062:extracellular exosome

0030246:carbohydrate binding

0005789:endoplasmic reticulum membrane

0005615:extracellular space

1901224:positive regulation of NIK/NF-kappaB signaling

0033116:endoplasmic reticulum-Golgi intermediate compartment membrane

0005829:cytosol

0002479:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent

0033144:negative regulation of intracellular steroid hormone receptor signaling pathway

0009897:external side of plasma membrane

0040020:regulation of meiotic nuclear division

0062023:collagen-containing extracellular matrix

0005794:Golgi apparatus

0005737:cytoplasm

0090398:cellular senescence

0045892:negative regulation of transcription, DNA-templated

0060473:cortical granule

0034975:protein folding in endoplasmic reticulum

0045665:negative regulation of neuron differentiation

PDB

3POW ; 3POS ; 5V90 ; 3DOW ; 5LK5 ; 2CLR ; 6ENY

Drugbank

DB09130 ; DB01065 ; DB13999 ; DB00025 ; DB00031 ; DB13998 ; DB14520 ; DB06245 ; DB11093 ; DB14481 ; DB13949 ; DB11348

KEGG

hsa:811

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0523	Cang Er Zi	苍耳子	fruit of siberian cockleblur	Fructus xanthii sibirici
H0669	Xie Bai	薤白	Longstamen onion	Allium macrostemon
H0937	Da Qing Ye	大青叶	Indigo-coloured woad leaf	Isatis indigotica
H0941	Da Zao	大枣	Chinese date	Ziziphus jujuba
H0542	Tian Ma	天麻	Tall gastrodia	Gastrodia elata
H0173	Lu Hui	芦荟	Kulaso aloe dried juice	Aloe vera
H0832	Zhu Sha Gen	朱砂根	Coral ardisia	Ardisia crenata
H0137	Ban Lan Gen	板蓝根	Indigowoad root	Isatis indigotica
H0195	Ma Chi Xian	马齿苋	Purslane	Portulaca oleracea
H1247	Huang Qi	黄芪	Membranous milkvetch	Astragalus membranaceus
H1200	Bai Mao Gen	白茅根	Lalang grass rhizome	Imperata cylindrica
H0855	Chuan Bei Mu	川贝母	Fritillaria unibracteata	Fritillaria cirrhosa
H0908	Ci Wu Jia	刺五加	Manypr ickle acanthopana x	Eleutherococcus senticosus
H0938	Da Suan	大蒜	Garlic	Allium sativum
H0331	Qiang Huo	羌活	Incised notopterygium	Notopterygium incisum
H0715	Che Qian Zi	车前子	seed of asiatic pantain	Plantago asiatica
H0631	Xi Yang Shen	西洋参	American ginseng	Panax quinquefolium
H0468	Shi Wei	石韦	Japanese felt fern frond	Pyrrosia lingua
H1251	Huang Qin	黄芩	Root of Baikal skullcaap	Scutellaria baicalensis
H0419	Shan Zha	山楂	Chinese hawthorn	Crataegus pinnatifida
H0537	Tian Dong	天冬	Cochinchinese asparagus root	Asparagus cochinchinensis
H0564	Tu Bei Mu	土贝母	Paniculate bolbostemma	Rhizoma bolbostemmae
H0972	Di Huang	地黄	Rehmanniae	Rehmannia glutinosa
H0427	Shan Zhu Yu	山茱萸	Asiatic cornelian cherry	Cornus officinalis
H0397	Sang Zhi	桑枝	White mulberry branch	Morus alba
H0168	Long Yan Rou	龙眼肉	Longan aril	Arillus longan
H0713	Che Qian Cao	车前草	all-grass of rippleseed plantain	Plantago depressa
H0357	Ren Shen	人参	Ginseng	Panax ginseng
H1030	Fang Feng	防风	Divaricate saposhnikovia	Saposhnikovia divaricata
H0390	Sang Ji Sheng	桑寄生	Parasite scurrula	Loranthus parasiticus
H0408	Bing Lang	槟榔	Betenutpalm	Areca catechu
H0971	Bai Bian Dou	白扁豆	White hyacinth bean	Lablab purpureus

Target Description

Related Compounds (Total: 3)

Related Herbs (Total: 32)