HIT-result

ID: C0242	Common name: Naringenin
IUPAC: (2S)-5,7-dihydroxy-2-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one	CAS: CAS:480-41-1
Chembl ID: CHEMBL9352	Pubchem ID: CID:439246
Formula: C15H12O5	TCM-ID: TCMC1734
Smiles: Oc1ccc(cc1)[C@@H]1CC(=O)c2c(O1)cc(cc2O)O
Alias: 4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-, (S)-; Flavanone, 4',5,7-trihydroxy-; Naringenin; (2S)-2,3-Dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; (-)-(2S)-Naringenin; (-)-Naringenin; (2S)-4',5,7-Trihydroxy-flavanone; (2S)-5,7-Dihydroxy-2-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one; (2S)-5,7-Dihydroxy-2-(4-hydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-4-one; (2S)-Naringenin; (S)-5,7-Dihydroxy-2-(4-hydroxyphenyl)chroman-4-one; (S)-Naringenin; NSC 11855; NSC 34875; Naringenine; Naringetol; S-Dihydrogenistein; Salipurol; Salipurpol; TCI-N 0072	Structure:

Target id	Protein Name	Gene Symbol	Uniprot ID	Target Level	No.of Literature Evidence
T88LSZ	Aromatase	CYP19A1	P11511	A	1 Reference(s)
T22OPB	Nuclear factor erythroid 2-related factor 2	NFE2L2	Q16236	A	2 Reference(s)
T57L0X	Oxysterols receptor LXR-alpha	NR1H3	Q13133	A	1 Reference(s)
T23VMI	Tumor necrosis factor	TNF	P01375	A	2 Reference(s)
T31U13	Cytochrome P450 2C19	CYP2C19	P33261	A	1 Reference(s)
T88TDZ	RAC-alpha serine/threonine-protein kinase	AKT1	P31749	A	1 Reference(s)
T82G3R	Integrin beta-3	ITGB3	P05106	A	1 Reference(s)
T78O6C	Mothers against decapentaplegic homolog 3	SMAD3	P84022	A	1 Reference(s)
T06RMZ	Nuclear factor NF-kappa-B p105 subunit	NFKB1	P19838	A	1 Reference(s)
T54SZZ	Endoplasmic reticulum chaperone BiP	HSPA5	P11021	B	1 Reference(s)
T20MBF	Serotransferrin	TF	P02787	B	1 Reference(s)
T53KY7	Cystic fibrosis transmembrane conductance regulator	CFTR	P13569	C	1 Reference(s)
T67ZT3	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	PTEN	P60484	C	1 Reference(s)
T63GUB	Proto-oncogene c-Fos	FOS	P01100	C	1 Reference(s)
T04HTN	Cyclic AMP-dependent transcription factor ATF-3	ATF3	P18847	C	1 Reference(s)
T05XOE	Macrophage mannose receptor 1	MRC1	P22897	C	1 Reference(s)
T79WXA	Mitogen-activated protein kinase 1	MAPK1	P28482	C	1 Reference(s)
T49PL1	Low-density lipoprotein receptor	LDLR	P01130	C	1 Reference(s)
T26KIE	Transcription factor AP-1	JUN	P05412	C	1 Reference(s)
T69NG6	Interleukin-10	IL10	P22301	C	1 Reference(s)

*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H1227	Huai Zhi	槐枝	NA	Sophora japonica
H1075	Gan Cao Liu Jin Gao	甘草流浸膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1073	Gan Cao Jie	甘草节	Glycyrrhiza uralensis fisch	Glycyrrhiza uralensis
H0093	Ju Pi	橘皮	Tangerine pericarp	Citrus reticulata
H0571	Tu Gan Cao	土甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0278	Nan Ban Lan Gen Jin Gao Fen	南板蓝根浸膏粉	Indigowoad root	Baphicacanthus cusia
H1067	Gan Cao Fen	甘草粉	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0965	Deng Zhan Xi Xin	灯盏细辛	Shortscape fleabane	Erigeron breviscapus
H1217	Bai Mei Hua	白梅花	Japanese apricot flower	Prunus mume
H0802	Zhi Geng	枳梗	NA	Citrus aurantium
H1070	Gan Cao Gan Gao Fen	甘草干膏粉	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1124	Guang Jin Qian Cao	广金钱草	Snowbellleaf tickclover	Desmodium styracifolium
H0663	Xiao Ji	小蓟	Setose thistle	Cirsium setosum
H0053	Jin Lian Hua	金莲花	Chinese globeflower	Trollius chinensis
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H1141	Guo Gang Long Jin Gao	过岗龙浸膏	NA	Entada phaseoloides
H1240	Huang Jing Zi	黄荆子	NA	Vitex negundo
H0705	Yan Hu Lu Ba	盐胡芦巴	Fenugreek	Trigonella foenum-graecum
H0932	Ba Qia	菝葜	Chinaroot greenbrier	Smilax china
H0804	Zhi Ke	枳壳	Seville ora nge unripe fruit	Citrus aurantium
H0629	Xi Xin	细辛	Siebold wildginger	Asarum sieboldii
H0805	Zhi Ke Gan Jin Gao	枳壳干浸膏	Seville ora nge unripe fruit	Citrus aurantium
H1098	Gou Ji	狗脊	Cochinchina cudrania	Cudrania cochinchinensis
H1140	Guo Gang Long	过岗龙	NA	Entada phaseoloides
H1069	Gan Cao Gan Gao	甘草干膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0088	Ju He	橘核	Tangerine seed	Citrus reticulata
H0758	Cheng Pi	橙皮	Bitter orange	Citrus aurantium
H0602	Wu Mei Rou	乌梅肉	Ebony	Prunus mume
H0240	Mi Gan Cao	蜜甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0446	Sheng Jiang	生姜	Fresh common ginger	Zingiber officinale
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H1074	Gan Cao Jin Gao	甘草浸膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0444	Sheng Gan Cao	生甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0813	Zhi Shi	枳实	Seville orange young fruit	Citrus aurantium
H0570	Tu Fu Ling	土茯苓	Glabrous greenbrier	Smilax glabra
H1161	Hang Ju	杭菊	Chrysanthemum flower	Chrysanthemum morifolium
H1224	Huai Jiao	槐角	pod of japanese pagodatree	Sophora japonica
H0601	Wu Mei	乌梅	Japanese apricot	Prunus mume
H0369	Bian Fu Ge	蝙蝠葛	Asiatic moonseed	Menispermum dauricum
H1222	Huai Hua	槐花	flower bud of japanese pagodatree	Sophora japonica
H0092	Ju Hua	菊花	Florists chrysanthemum flower	Chrysanthemum morifolium
H1066	Gan Cao	甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0277	Nan Ban Lan Gen	南板蓝根	Indigowoad root	Baphicacanthus cusia
H0582	Cao Dou Kou Ren	草豆蔻仁	Katsumada galangal	Alpinia katsumadai
H0089	Ju Hong	橘红	NA	Citri exocarpium rubrum
H0219	Man Shan Hong	满山红	Dahurian rhododendron	Rhododendron dauricum
H1071	Gan Cao Gan Jin Gao	甘草干浸膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1133	Gui Jian Yu	鬼箭羽	Winged euonymus	Euonymus alatus
H1225	Huai Mi	槐米	NA	Sophora japonica
H1034	Fei Yang Cao	飞杨草	NA	Euphorbia hirta
H0574	Cao Dou Kou	草豆蔻	Katsumada galangal	Alpinia katsumadai
H0166	Long Kui	龙葵	Black nightshade	Solanum nigrum
H0457	Shi Er	石耳	Rock-Ears	Umbilicaria esculenta
H0002	Hui Xiang	茴香	Fennel fruit	Foeniculum vulgare
H1072	Gan Cao Gao	甘草膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0164	Ban Zhi Lian	半枝莲	Barbed skullcap	Scutellaria barbata

Compound Description

Related Targets (Total: 20)

Related Herbs (Total: 56)