ID: C0053 | Common name: Esculetin |
IUPAC: 6,7-dihydroxychromen-2-one | CAS: CAS:305-01-1 |
Chembl ID: CHEMBL244743 | Pubchem ID: CID:5281416 |
Formula: C9H6O4 | TCM-ID: TCMC1131 |
Smiles: C1=CC(=O)OC2=CC(=C(C=C21)O)O | |
Alias:
Coumarin, 6,7-dihydroxy-;
Esculetin; 6,7-Dihydroxy-2H-1-benzopyran-2-one; 6,7-Dihydroxy-2-benzopyrone; 6,7-Dihydroxycoumarin; Aesculetin; Asculetine; Cichorigenin; Cichoriin aglycon; Esculetol; Esculin aglycon; NSC 26428 |
Structure: |
Target id | Protein Name | Gene Symbol | Uniprot ID | Target Level | No.of Literature Evidence |
---|---|---|---|---|---|
T85U8U | Caspase-3 | CASP3 |
P42574 |
B | 1 Reference(s) |
T71K92 | Apoptosis regulator Bcl-2 | BCL2 |
P10415 |
B | 1 Reference(s) |
T75H3W | Cyclin-dependent kinase 2 | CDK2 |
P24941 |
B | 1 Reference(s) |
T10S5F | Cyclin-dependent kinase 4 | CDK4 |
P11802 |
B | 1 Reference(s) |
T64W2K | Cyclin-dependent kinase inhibitor 1 | CDKN1A |
P38936 |
B | 1 Reference(s) |
T36YWU | Kelch-like ECH-associated protein 1 | KEAP1 |
Q14145 |
B | 1 Reference(s) |
T80OJF | Interstitial collagenase | MMP1 |
P03956 |
C | 1 Reference(s) |
T41TXS | Retinoblastoma-associated protein | RB1 |
P06400 |
C | 1 Reference(s) |
T20H9F | Stromelysin-1 | MMP3 |
P08254 |
C | 1 Reference(s) |
T70B7U | Angiotensin-converting enzyme 2 | ACE2 |
Q9BYF1 |
C | 1 Reference(s) |
Herb id | Chinese Pin Yin | Chinese Character | English Name | Latin Name |
---|---|---|---|---|
H0064 | Jin Yin Hua | 金银花 | Japanese honeysuckle | Lonicera japonica |
H0613 | Wu Yue Ai | 五月艾 | Artemisia | Artemisia princeps |
H0802 | Zhi Geng | 枳梗 | NA | Citrus aurantium |
H0804 | Zhi Ke | 枳壳 | Seville ora nge unripe fruit | Citrus aurantium |
H1072 | Gan Cao Gao | 甘草膏 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
H0813 | Zhi Shi | 枳实 | Seville orange young fruit | Citrus aurantium |
H0585 | Tu Yin Chen Hao | 土茵陈蒿 | Capillary wormwood | Artemisia capillaris |
H0154 | Ai Ye You | 艾叶油 | Argy wormwood leaf | Artemisia argyi |
H1075 | Gan Cao Liu Jin Gao | 甘草流浸膏 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
H1073 | Gan Cao Jie | 甘草节 | Glycyrrhiza uralensis fisch | Glycyrrhiza uralensis |
H0065 | Jin Yin Hua Ti Qu Ye | 金银花提取液 | Japanese honeysuckle | Lonicera japonica |
H0083 | Jiu Jie Cha | 九节茶 | Glabrous sarcandra | Sarcandra glabra |
H1138 | Bai Jiang Cao | 败酱草 | All - grass of dahurian patrinia | Thlaspi arvense |
H0956 | Dang Gui Gan Jin Gao | 当归干浸膏 | NA | Angelica sinensis |
H0746 | Yin Chen Hao Gan Jin Gao | 茵陈蒿干浸膏 | Capillary wormwood | Artemisia capillaris |
H0541 | Cang Qie Gen | 藏茄根 | Tibetan eggplant root | Anisodus tanguticus |
H1225 | Huai Mi | 槐米 | NA | Sophora japonica |
H1244 | Huang Miao | 黄苗 | NA | Taraxacum mongolicum |
H0391 | Sang Pi | 桑皮 | Prepared root-bark white mulberry | Morus alba |
H0640 | Xiang Fu | 香附 | Nutgrass galingale | Cyperus rotundus |
H0988 | Ding Gong Teng | 丁公藤 | Obtuseleaf Erycibe Stem | Erycibe obtusifolia |
H0269 | Mu Gua | 木瓜 | Chinese floweringquince | Chaenomeles sinensis |
H0396 | Sang Ye | 桑叶 | White mulberry leaf | Morus alba |
H1222 | Huai Hua | 槐花 | flower bud of japanese pagodatree | Sophora japonica |
H0418 | Shan Yin Chen | 山茵陈 | Capillary wormwood | Artemisia capillaris |
H1227 | Huai Zhi | 槐枝 | NA | Sophora japonica |
H1070 | Gan Cao Gan Gao Fen | 甘草干膏粉 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
H0528 | Tao Jin Niang Gen | 桃金娘根 | Downy rosemyrtle root | Rhodomyrtus tomentosa |
H0428 | Shang Lu | 商陆 | Indian pokeweed | Phytolacca esculenta |
H0413 | Shan Lang Dang | 山莨菪 | NA | Anisodus tanguticus |
H1188 | Hong Hua | 红花 | Safflower | Carthamus tinctorius |
H0551 | Cang Zhu | 苍术 | Swordlike atractylodes | Atractylodes lancea |
H1046 | Feng Xian Tou Gu Cao | 凤仙透骨草 | Spotted snapweed | Impatiens balsamina |
H1045 | Feng Xian Hua | 凤仙花 | Spotted snapweed | Impatiens balsamina |
H1201 | Hu Er Cao | 虎耳草 | Creeping rockfoil | Saxifraga stolonifera |
H1221 | Hua Xiang Shu Guo Xu | 化香树果序 | NA | Platycarya strobilacea |
H1067 | Gan Cao Fen | 甘草粉 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
H1224 | Huai Jiao | 槐角 | pod of japanese pagodatree | Sophora japonica |
H1231 | Huang Bai Tan | 黄柏炭 | Amur corktree | Phellodendron amurense |
H0015 | Ji Xing Zi | 急性子 | Garden balsam seed | Impatiens balsamina |
H0614 | Wu Zhao Long | 五爪龙 | Cairo morningglory | Ipomoea cairica |
H0094 | Gou Qi | 枸杞 | Chinese wolfberry fruit | Lycium chinense |
H0805 | Zhi Ke Gan Jin Gao | 枳壳干浸膏 | Seville ora nge unripe fruit | Citrus aurantium |
H1016 | Du Zhong Tan | 杜仲炭 | Eucommia | Eucommia ulmoides |
H0354 | Ren Dong Teng | 忍冬藤 | Japanese honeysuckle vine | Lonicera japonica |
H1074 | Gan Cao Jin Gao | 甘草浸膏 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
H1017 | Du Zhong Ye | 杜仲叶 | Eucommia leaf | Eucommia ulmoides |
H0325 | Qian Jin Zi | 千金子 | Caper euphorbia seed | Euphorbia lathyris |
H0745 | Yin Chen Hao | 茵陈蒿 | Capillary wormwood | Artemisia capillaris |
H0612 | Cao Shan Hu Jin Gao | 草珊瑚浸膏 | NA | Sarcandra glabra |
H1069 | Gan Cao Gan Gao | 甘草干膏 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
H0314 | Pu Gong Ying | 蒲公英 | Mongolian dandelion | Taraxacum mongolicum |
H0315 | Pu Gong Ying Jin Gao | 蒲公英浸膏 | Mongolian dandelion | Taraxacum mongolicum |
H0095 | Gou Qi Zi | 枸杞子 | Chinese wolfberry fruit | Lycium chinense |
H0103 | Ai Ye | 艾叶 | Argy wormwood leaf | Artemisia argyi |
H0758 | Cheng Pi | 橙皮 | Bitter orange | Citrus aurantium |
H1015 | Du Zhong | 杜仲 | Eucommia | Eucommia ulmoides |
H0240 | Mi Gan Cao | 蜜甘草 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
H0104 | Bai Zhu | 白术 | Largehead atractylodes | Atractylodes macrocephala |
H1066 | Gan Cao | 甘草 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
H1115 | Guan Huang Bai | 关黄柏 | Amur cork tree | Phellodendron amurense |
H1089 | Gang Ren Zi | 岗稔子 | rose myrtle | Rhodomyrtus tomentosa |
H1230 | Huang Bai Fen | 黄柏粉 | Amur corktree | Phellodendron amurense |
H0035 | Bai Su Zi | 白苏子 | Common perilla fruit | Perilla frutescens |
H0704 | Yan Guan Huang Bai | 盐关黄柏 | Amur cork tree | Phellodendron amurense |
H0139 | Lian Qiao | 连翘 | Weeping forsythia | Forsythia suspensa |
H0273 | Mu Tong | 木通 | Fiveleaf akebia | Akebia quinata |
H0397 | Sang Zhi | 桑枝 | White mulberry branch | Morus alba |
H0444 | Sheng Gan Cao | 生甘草 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
H0335 | Qin Pi | 秦皮 | bark of largeleaf chinese ash | Cortex fraxini |
H0053 | Jin Lian Hua | 金莲花 | Chinese globeflower | Trollius chinensis |
H1228 | Huang Bai | 黄柏 | Amur corktree | Phellodendron amurense |
H0536 | Tian Di Ding | 甜地丁 | Manyflower gueldenstaedtid herb | Viola philippica |
H1128 | Bai Jiang | 败酱 | Whiteflower patrinia | Patrinia villosa |
H1056 | Fu Pen Zi | 覆盆子 | Red-and-Yellow garden raspberry | Rubus idaeus |
H1220 | Hua Xiang Shu Guo | 化香树果 | NA | Platycarya strobilacea |
H0571 | Tu Gan Cao | 土甘草 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
H1071 | Gan Cao Gan Jin Gao | 甘草干浸膏 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
H0955 | Dang Gui | 当归 | Chinese angelica | Angelica sinensis |