HIT-result

Target Description

Type	Detail
Target ID	T47DYR
Protein Name	P2Y purinoceptor 1
Uniprot ID	P47900
Protein Name Alias	P2Y1; ADP receptor; Purinergic receptor
Gene ID	5028
Gene Symbol	P2RY1
Gene Alias	NA
TTD	T67818: Research target
Pfam	PF00001
GO	0008347:glial cell migration 0007568:aging 0060406:positive regulation of penile erection 0038023:signaling receptor activity 0030425:dendrite 0046887:positive regulation of hormone secretion 0099509:regulation of presynaptic cytosolic calcium ion concentration 0097110:scaffold protein binding 0030168:platelet activation 0007204:positive regulation of cytosolic calcium ion concentration 0009612:response to mechanical stimulus 0016324:apical plasma membrane 0098978:glutamatergic synapse 0009986:cell surface 2000300:regulation of synaptic vesicle exocytosis 0014069:postsynaptic density 0071415:cellular response to purine-containing compound 0045211:postsynaptic membrane 0032962:positive regulation of inositol trisphosphate biosynthetic process 0007200:phospholipase C-activating G protein-coupled receptor signaling pathway 0031686:A1 adenosine receptor binding 0090075:relaxation of muscle 0051100:negative regulation of binding 0005887:integral component of plasma membrane 0010469:regulation of signaling receptor activity 0005524:ATP binding 0001973:G protein-coupled adenosine receptor signaling pathway 0005886:plasma membrane 0044297:cell body 0001934:positive regulation of protein phosphorylation 0045028:G protein-coupled purinergic nucleotide receptor activity 0010700:negative regulation of norepinephrine secretion 0043270:positive regulation of ion transport 0070848:response to growth factor 0070374:positive regulation of ERK1 and ERK2 cascade 0099059:integral component of presynaptic active zone membrane 0072659:protein localization to plasma membrane 0008360:regulation of cell shape 0043531:ADP binding 0001621:G protein-coupled ADP receptor activity 0005929:cilium 0005739:mitochondrion 0097746:blood vessel diameter maintenance 0045031:G protein-coupled ATP receptor activity 0042755:eating behavior 0046982:protein heterodimerization activity 0007186:G protein-coupled receptor signaling pathway 0019233:sensory perception of pain 0023019:signal transduction involved in regulation of gene expression 0016323:basolateral plasma membrane 0007193:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway 0007166:cell surface receptor signaling pathway 0071318:cellular response to ATP 0045944:positive regulation of transcription by RNA polymerase II
PDB	4XNW ; 4XNV ; 1Y36
Drugbank	DB01069
KEGG	hsa:5028

Type

Detail

Target ID

T47DYR

Protein Name

P2Y purinoceptor 1

Uniprot ID

P47900

Protein Name Alias

P2Y1; ADP receptor; Purinergic receptor

Gene ID

5028

Gene Symbol

P2RY1

Gene Alias

TTD

T67818: Research target

Pfam

PF00001

0008347:glial cell migration

0007568:aging

0060406:positive regulation of penile erection

0038023:signaling receptor activity

0030425:dendrite

0046887:positive regulation of hormone secretion

0099509:regulation of presynaptic cytosolic calcium ion concentration

0097110:scaffold protein binding

0030168:platelet activation

0007204:positive regulation of cytosolic calcium ion concentration

0009612:response to mechanical stimulus

0016324:apical plasma membrane

0098978:glutamatergic synapse

0009986:cell surface

2000300:regulation of synaptic vesicle exocytosis

0014069:postsynaptic density

0071415:cellular response to purine-containing compound

0045211:postsynaptic membrane

0032962:positive regulation of inositol trisphosphate biosynthetic process

0007200:phospholipase C-activating G protein-coupled receptor signaling pathway

0031686:A1 adenosine receptor binding

0090075:relaxation of muscle

0051100:negative regulation of binding

0005887:integral component of plasma membrane

0010469:regulation of signaling receptor activity

0005524:ATP binding

0001973:G protein-coupled adenosine receptor signaling pathway

0005886:plasma membrane

0044297:cell body

0001934:positive regulation of protein phosphorylation

0045028:G protein-coupled purinergic nucleotide receptor activity

0010700:negative regulation of norepinephrine secretion

0043270:positive regulation of ion transport

0070848:response to growth factor

0070374:positive regulation of ERK1 and ERK2 cascade

0099059:integral component of presynaptic active zone membrane

0072659:protein localization to plasma membrane

0008360:regulation of cell shape

0043531:ADP binding

0001621:G protein-coupled ADP receptor activity

0005929:cilium

0005739:mitochondrion

0097746:blood vessel diameter maintenance

0045031:G protein-coupled ATP receptor activity

0042755:eating behavior

0046982:protein heterodimerization activity

0007186:G protein-coupled receptor signaling pathway

0019233:sensory perception of pain

0023019:signal transduction involved in regulation of gene expression

0016323:basolateral plasma membrane

0007193:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

0007166:cell surface receptor signaling pathway

0071318:cellular response to ATP

0045944:positive regulation of transcription by RNA polymerase II

PDB

4XNW ; 4XNV ; 1Y36

Drugbank

DB01069

KEGG

hsa:5028

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0338	Qing Ban Xia	清半夏	Ternate pinellia	Pinellia ternata
H0155	Ban Xia	半夏	Ternate pinellia	Pinellia ternata
H0638	Xiang Bei	象贝	Fritillaria	Fritillaria thunbergii
H0159	Ban Xia Qu	半夏曲	Pinellia tuber leaven	Pinellia ternata
H0941	Da Zao	大枣	Chinese date	Ziziphus jujuba
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0018	Ji Xue Teng Gan Gao	鸡血藤干膏	Suberect spatholobus stem	Spatholobus suberectus
H0995	Dong Chong Xia Cao	冬虫夏草	Aweto	Cordyceps sinensis
H0855	Chuan Bei Mu	川贝母	Fritillaria unibracteata	Fritillaria cirrhosa
H0938	Da Suan	大蒜	Garlic	Allium sativum
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0019	Ji Xue Teng Gao	鸡血藤膏	Suberect spatholobus stem	Spatholobus suberectus
H0153	Ling Zhi(1)	灵芝	Lucid ganoderma	Ganoderma lucidum
H0439	Sheng Ban Xia	生半夏	Ternate pinellia	Pinellia ternata
H0981	Dian Ji Xue Teng Gao Fen	滇鸡血藤膏粉	Suberect spatholobus stem	Spatholobus suberectus
H0017	Ji Xue Teng	鸡血藤	Suberect spatholobus stem	Spatholobus suberectus
H0311	Ping Bei Mu	平贝母	Ussuri fritillary	Fritillaria ussuriensis
H0735	Yi Bei Mu	伊贝母	Siberian fritillary equivalent plant: fritillaria walujewii	Fritillaria pallidiflora
H0843	Zi Bei Mu	紫贝母	NA	Fritillaria unibracteata
H0859	Chuan Bei Mu Liu Jin Gao	川贝母流浸膏	Fritillaria unibracteata	Fritillaria cirrhosa
H0152	Ling Zhi Jin Gao	灵芝浸膏	NA	Ganoderma lucidum

Target Description

Related Compounds (Total: 5)

Related Herbs (Total: 21)